3D printing with star-shaped strands: A new approach to enhance in vivo bone regeneration

Raymond, Yago; Lehmann, Cyril; Thorel, Emilie; Benítez, Raúl; Riveiro, A.; Pou, J.; Manzanares-Céspedes, María Cristina; Franch, Jordi; Canal, Cristina; Ginebra, Maria‐Pau

doi:10.1016/j.bioadv.2022.212807

Cited by 7 publications

(3 citation statements)

References 46 publications

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“…Each shape offers distinct advantages: Circles are versatile like conventional fixed nozzles, allowing printing in any direction; squares minimize interfilament voids in solid structures; concave shapes like stars enhance bonding in applications such as bone grafts ( 7 ). Switching between operational modes is straightforward, requiring only changes in cable routing.…”

Section: Resultsmentioning

confidence: 99%

“…These and other limitations substantially impede the broader adoption and advancement of additive manufacturing and its applications. Multiscale features, which are common in numerous engineered systems, particularly in biologically relevant applications like artificial vascular networks ( 6 ) and bone grafts ( 7 ), and in other areas such as heat sinks ( 8 ) and graded lattices ( 9 ), would benefit substantially from an adaptive extrusion nozzle in both performance and printing speed. In addition, in the fabrication of standard 3D solid structures using extrusion-based printers, size-variable filaments can address the inherent discrepancies between intended and actual shapes caused by fixed-size, cylindrical filaments, by eliminating interfilament voids and facilitating smoother surfaces.…”

Section: Introductionmentioning

confidence: 99%

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Multiscale 3D printing via active nozzle size and shape control

Kang,

Mueller

2024

Sci. Adv.

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Three-dimensional (3D) printers extruding filaments through a fixed nozzle encounter a conflict between high resolution, requiring small diameters, and high speed, requiring large diameters. This limitation is especially pronounced in multiscale architectures featuring both bulk and intricate elements. Here, we introduce adaptive nozzle 3D printing (AN3DP), a technique enabling dynamic alteration of nozzle diameter and cross-sectional shape during printing. The AN3DP nozzle consists of eight independently controllable, tendon-driven pins arrayed around a flexible, pressure-resistant membrane. The design incorporates a tapered angle optimized for extruding shear-thinning inks and a pointed tip suitable for constrained-space printing, such as conformal and embedded printing. AN3DP’s efficacy is demonstrated through the fabrication of components with continuous gradients, eliminating the need for discretization, and achieving enhanced density and contour precision compared to traditional 3D printing methods. This platform substantially expands the scope of extrusion-based 3D printers, thus facilitating diverse applications, including bioprinting cell-laden and hierarchical implants with bone-like microarchitecture.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multiscale 3D printing via active nozzle size and shape control

Kang,

Mueller

2024

Sci. Adv.

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“…A major advancement in tissue engineering is the use of 3D printing materials which has advanced the field and opened doors to in vitro testing of new biomaterials; however, the methodology is often overlooked when characterizing these materials. 40 To perform in vitro testing using 3D-printed biomaterials, groups often need to cut or manipulate their material or print very small constructs to be used in larger well plates to allow for the proximity of the material to the cell monolayer. [41][42][43] Most commonly, groups produce extracts of the material being tested and then expose cell cultures to these materials at pre-determined concentrations as a liquid or pharmaceutical treatment.…”

Section: Resultsmentioning

confidence: 99%