3D screen printing – An innovative technology for large-scale manufacturing of pharmaceutical dosage forms

Moldenhauer, Daniel; Nguyen, Doan Chau Yen; Jescheck, Lisa; Hack, Franz J.; Fischer, Dagmar; Schneeberger, Achim

doi:10.1016/j.ijpharm.2020.120096

Cited by 21 publications

(12 citation statements)

References 25 publications

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“…Moldenhauer et al used 3D screen printing to produce delayed-release paracetamol tablets on a large scale. The layout of the printing screen was designed in such a way that tablets with five different geometries (disk, donut, cuboid, oval, and grid), each in three different sizes (small, medium, large) could be produced during the same production process [ 15 ]. The results of the hardness test showed that all tablets had very good mechanical properties and high resistance to crushing.…”

Section: Resultsmentioning

confidence: 99%

“…Indicatively, the breaking force for the disks is reported to increase with size from about 100 N for the S size to about 200 N for the L size. Finally, all tablets exhibited extremely low friability (0.1%), from which it can be concluded that the physical tablet properties of 3D screen-printed tablets are by no means of lower quality than those of conventionally pressed tablets [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, there is still a long way to go before 3D printing is integrated into clinical practice. To date, there is no technology that can be used for large-scale production, with the exception of screen 3D printing, which was recently proposed by Moldenhauer et al [ 15 ]. 3D screen printing is based on the transfer of API-containing printing paste through specific openings of the printing screen onto a given substrate.…”

Section: Introductionmentioning

confidence: 99%

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3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

et al. 2021

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The aim of this review is to present the factors influencing the mechanical properties of 3D-printed oral dosage forms. It also explores how it is possible to use specific excipients and printing parameters to maintain the structural integrity of printed drug products while meeting the needs of patients. Three-dimensional (3D) printing is an emerging manufacturing technology that is gaining acceptance in the pharmaceutical industry to overcome traditional mass production and move toward personalized pharmacotherapy. After continuous research over the last thirty years, 3D printing now offers numerous opportunities to personalize oral dosage forms in terms of size, shape, release profile, or dose modification. However, there is still a long way to go before 3D printing is integrated into clinical practice. 3D printing techniques follow a different process than traditional oral dosage from manufacturing methods. Currently, there are no specific guidelines for the hardness and friability of 3D printed solid oral dosage forms. Therefore, new regulatory frameworks for 3D-printed oral dosage forms should be established to ensure that they meet all appropriate quality standards. The evaluation of mechanical properties of solid dosage forms is an integral part of quality control, as tablets must withstand mechanical stresses during manufacturing processes, transportation, and drug distribution as well as rough handling by the end user. Until now, this has been achieved through extensive pre- and post-processing testing, which is often time-consuming. However, computational methods combined with 3D printing technology can open up a new avenue for the design and construction of 3D tablets, enabling the fabrication of structures with complex microstructures and desired mechanical properties. In this context, the emerging role of computational methods and artificial intelligence techniques is highlighted.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

et al. 2021

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“…Firstly, the research objective is defined, such as 'optimise the strength of 3DP tablets'. Next, researchers must consider what process variables are likely to have a considerable impact on the outcome [125]. This step requires specialist process knowledge, careful consideration of all possibilities, and elimination of bias.…”

Section: Design Of Experimentsmentioning

confidence: 99%

Harnessing artificial intelligence for the next generation of 3D printed medicines

Elbadawi

McCoubrey

Gavins

et al. 2021

Advanced Drug Delivery Reviews

110

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…The study of drug release tests performed in artificial gastric media showed that paracetamol release depends on surface-to-area volume ratio. Studies of 3D printing enable potential manufacture of complex oral dosage forms for mass production with more reproducibility [8]. Thermoresponsive polymer poly(N-isopropylacrylamide) (PNIPAAm)-co-acrylic acid hydrogel was documented and effectively used for different kinds of 3D printing, including 3D single nozzle expulsion printing, 3D coaxial printing, and 3D hybrid printing.…”

Section: Introductionmentioning

confidence: 99%

3D Printing in Development of Nanomedicines

et al. 2021

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Three-dimensional (3D) printing is gaining numerous advances in manufacturing approaches both at macro- and nanoscales. Three-dimensional printing is being explored for various biomedical applications and fabrication of nanomedicines using additive manufacturing techniques, and shows promising potential in fulfilling the need for patient-centric personalized treatment. Initial reports attributed this to availability of novel natural biomaterials and precisely engineered polymeric materials, which could be fabricated into exclusive 3D printed nanomaterials for various biomedical applications as nanomedicines. Nanomedicine is defined as the application of nanotechnology in designing nanomaterials for different medicinal applications, including diagnosis, treatment, monitoring, prevention, and control of diseases. Nanomedicine is also showing great impact in the design and development of precision medicine. In contrast to the “one-size-fits-all” criterion of the conventional medicine system, personalized or precision medicines consider the differences in various traits, including pharmacokinetics and genetics of different patients, which have shown improved results over conventional treatment. In the last few years, much literature has been published on the application of 3D printing for the fabrication of nanomedicine. This article deals with progress made in the development and design of tailor-made nanomedicine using 3D printing technology.

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3D screen printing – An innovative technology for large-scale manufacturing of pharmaceutical dosage forms

Cited by 21 publications

References 25 publications

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

Harnessing artificial intelligence for the next generation of 3D printed medicines

3D Printing in Development of Nanomedicines

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