This study examines the concentrations of air pollution in the vicinity of a combined heat and power plant (CHP) and a communication route, using computer modeling of pollutant dispersion and spatial analysis based on real measurements in the city of Łódź, Poland, Europe. The research takes into account the concentrations of particulate matter (PM10, PM2.5, PM1.0) and gaseous pollutants (SO2 and VOC) in winter and summer. The spatial distribution of pollutants is discussed, including the presence of areas with increased accumulations of pollutants. Because atmospheric air has no natural boundaries, when analyzing any location, not only local sources of pollution, but also background pollution, should be analyzed. A clear difference was observed between the concentrations of pollutants in the summer and winter seasons, with significantly higher concentrations in the winter (heating) period. The impacts of road transport, individual heating systems, and combined heat and power plants were also assessed. Computer calculations confirmed that road transport accounted for the largest share of both PM and SO2 emissions. The CHP plant was responsible for the smallest percentage of dust emissions and was the next largest producer of SO2 emissions. The share of the total emissions from the individual sources were compared with the results of detailed field tests. The numerical analysis of selected pollution sources in combination with the field analysis shows that the identified pollution sources included in the analysis represent only a part of the total observed pollutant concentrations (suggesting that other background sources account for the rest).