3D stereophotogrammetry in children and adolescents with Scleroderma En Coup De Sabre/Parry‐Romberg Syndrome: Description of a novel method for monitoring disease progression

Abstract

Background The diagnosis of Scleroderma En Coup de Sabre (ECDS)/Parry Romberg Syndrome (PRS) is mainly based on characteristic clinical findings. Methods to objectively monitor the course of the disease in a standardized way are lacking. Objectives This descriptive, retrospective, single centre cohort study aims to describe the contribution of 3D photographs in the assessment of the degree of facial asymmetry changes over time in growing children and adolescents with ECDS and PRS. Methods Six patients diagnosed with ECDS/PRS, with a follow‐up period of at least 24 months and at least three 3D photographs were included. Mirroring these 3D photographs was automatically performed using surface‐based matching to generate a colour‐coded distance map, illustrating the inter‐surface distance and thereby asymmetry between the original and mirrored 3D photographs. The percentage of absolute distances between the original and mirrored 3D photograph were calculated. Results In two patients, impressive decreases in the percentages of absolute distance levels over time were found, whereas the other patients did not show progression of asymmetry over time. Conclusion This study shows the potential of 3D stereophotogrammetry as an objective tool to measure disease activity over time in patients with ECDS/PRS.

Craniofacial disorders and dysplasias: Molecular, clinical, and management perspectives

“…The patients have facial asymmetry, dental anomalies, delayed eruption and temporomandibular joint dysfunctions. The disease starts within the first two decades of life but may eventually reach a “burn-out” phase ( Ter Horst et al, 2022 ).…”