3D turbo field echo with diffusion-sensitized driven-equilibrium preparation technique (DSDE-TFE) <i>versus</i> echo planar imaging in evaluation of diffusivity of retinoblastoma

Hiwatashi, Akio; Togao, Osamu; Yamashita, Koji; Kikuchi, Kazufumi; Yoshikawa, Hiroshi; Obara, Makoto; Honda, Hiroshi

doi:10.1259/bjr.20160074

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…On the DSDE-TFE, the mean ADC value was 1.73 ± 0.73 × 10 -3 mm 2 /s. On the EP images, the mean ADC value was 0.93 ± 0.53 × 10 -3 mm 2 /s with significant correlation between DSDE-TFE and EP images [ 12 ]. The variety in mean ADC values in these studies may be because of: 1) different tumour cellularity/stage in different study patient groups; 2) subjective measurement methods; or 3) different technical parameters using different MRI devices for the different studies.…”

Section: Discussionmentioning

confidence: 99%

A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features

Orman¹,

Huisman²

2022

Pol J Radiol

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Purpose: Retinoblastoma (RB) is the most common intraocular malignancy of childhood. Magnetic resonance imaging (MRI) is essential for initial diagnosis, tumour extension, staging, and treatment planning of RB. Awareness of neuro imaging findings and determining local extent are essential for early diagnosis and therapy guidance. The purpose of this study is to evaluate and to provide a detailed list of neuroimaging features of RB to improve the diagnostic workup of children with RB. Material and methods:Retrospective review was performed among children with confirmed RB diagnosis. MRI features were identified to evaluate: 1) growth pattern; 2) intraocular extension; 3) extraocular extension; 4) central nervous system disease; 5) conventional MRI characteristics of the RB lesions; and 6) DWI and ADC characteristics. These features were compared between unilateral and bilateral RB lesions. Results:Twentyfour children (male/female: 18/6) were included in this study. The mean age at the time of diagnosis was 14.7 (11.4) months. In total, 34 RB lesions (bilateral = 18) were evaluated for the study. The most common fea tures on MRI were: 1) endophytic RB lesion (50%); 2) subretinal haemorrhage (38%); 3) scleral involvement (3%); 4) leptomeningeal disease (12%); 5) contrast enhancement (97%); and 6) restricted diffusion (88%). The mean ADC value was 0.64 (0.15) × 10 3 mm 2 /s. Choroidal invasion (p = 0.05) and scleral involvement (p = 0.04) were significantly higher for bilateral RB lesions. Conclusions:Contrast enhancement and restricted diffusion are the most common neuroimaging features of RB.Choroidal invasion and scleral involvement are more frequently seen in bilateral disease.

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Section: Discussionmentioning

confidence: 99%

A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features

Orman¹,

Huisman²

2022

Pol J Radiol

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“…In our study, echoplanar (EP)-based DWIs yields susceptibility artifacts and image distortion. Hiwatashi A et al [10] correlated EP DWIs and 3D single-shot turbo spin echo to obtain DWIs with higher spatial resolution and less image distortion. They stated that turbo spin-echo sequence is compatible to assess the diffusivity and ADC values of retinoblastoma owing to its insensitivity to field inhomogeneity despite its longer acquisition time.…”

Section: Discussionmentioning

confidence: 99%

“…DWI is based on an echoplanar sequence that is fast yet sensitive to susceptibility artifacts and image distortions, particularly at air-tissue and bone-tissue interfaces. Therefore, DWI of the orbit is challenging [10].…”

Section: Introductionmentioning

confidence: 99%

“…Although several studies have reported the diagnostic accuracy of MRI in detecting intraocular tumor extent and metastasis [3,[6][7][8][9][10][11][12][13][14][15], our study provides a comprehensive evaluation of the diagnostic accuracy of 3 T ocular MRI, diagnostic role of DWIs, sensitivity, and specificity of different tumor diameter cut off values of postlaminar optic nerve invasion (PLONI) and ocular coat invasion as well as the relationship of the abnormal anterior eye segment enhancement in MRI examinations of retinoblastoma and different MRI and histopathological findings which, to our knowledge, are grouped in few studies. This prospective study aims to evaluate the preoperative MR imaging diagnostic value in pathologically proved retinoblastoma patients.…”

Section: Introductionmentioning

confidence: 99%

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High Resolution MR Imaging guidelines in retinoblastoma: prospective study correlated with histopathological results

Habib

Youssef

AlKiki

et al. 2020

Egypt J Radiol Nucl Med

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Background: Retinoblastoma is the commonest intraocular pediatric neoplasm. With the recent scope of shifting to eye preserving therapies, preoperative MRI is becoming the primary noninvasive diagnostic method to confirm the diagnosis, assess the ocular coats and optic nerve, and detect extraocular tumor extension and intracranial primitive neuroectodermal tumor associated with retinoblastoma as funduscopy and ultrasound have limitations. Diffusion-weighted images (DWIs) detect abnormalities based on differences in tissue cellularity. Echoplanar-based (EP) DWI results in susceptibility artifacts and geometric distortions, which make DWI of the orbit a challenging technique. The purpose of our study is to evaluate preoperative magnetic resonance (MR) imaging diagnostic merits and indices in patients with retinoblastoma. Results: Fifty-eight eyes were prospectively reviewed in 30 girls and 27 boys (mean age at diagnosis was 23 months ± 18.9) with retinoblastoma by two radiologists on T1-weighted images, fat saturated T2-weighted images, DWIs, ADC, and postcontrast T1-weighted MR images with and without fat suppression. All patients included were primarily treated by surgical enucleation; one girl had bilateral enucleation. MRI shows accuracy, sensitivity, specificity, NPV, and PPV; 86.2%, 95.3%, 60%, 81.8%, and 87.2% respectively for choroidal invasion; 75.8%, 58.8%, 82.9%, 83%, and 58.8% in prelaminar optic nerve invasion; and 86.2%, 85.2%, 87%, 87%, and 85% in postlaminar optic nerve invasion (PLONI) respectively. For sclera and extrascleral tumor invasion, MRI show accuracy, sensitivity, specificity, NPV, and PPV of 93%, 55.6%, 100%, 92.5%, 100%, and 98.3%, 100%, 98%,100%, 80% respectively. On DWIs, the vital solid tumor shows hyperintense signal compared to the vitreous. The difference between the mean ADC value of the solid enhancing tumor (0.3[0.12-0.8] × 10 −3 s/mm 2) and nonenhancing necrotic parts (1.4[1.0-1.8] × 10 −3 s/mm 2) was statistically significant (p < 0.001). No correlation was found between the ADC values and high risk features for metastasis. Abnormal anterior chamber enhancement shows no statistically significant correlation with main MRI and histopathology findings. Maximum tumor diameter in mm show statistically significant correlation with postlaminar optic nerve invasion (ρ = .002) and choroidal invasion (ρ = .007). Sensitivity and specificity of different tumor size cutoff values are calculated using the ROC analysis. Conclusion: High-resolution ocular MR imaging can reliably detect postlaminar optic nerve invasion, choroid, and extrascleral invasion; meanwhile, it shows low sensitivity in prelaminar optic nerve, ciliary body, and sclera invasion. Significantly lower ADC values in viable tumor than necrotic parts are recorded.

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“…For most individuals, trilateral retinoblastoma is deadly; however, early discovery and aggressive (chemo) therapy may be lifesaving for others. [11,12] Although previous studies have reported the diagnostic accuracy of MRI in detecting intraocular tumour extent and metastasis [13][14][15], our study provides a comprehensive evaluation of the diagnostic accuracy of 3 T ocular MRI, diagnostic role of DWIs, sensitivity, and specificity of different tumour diameter cut off values of post laminar optic nerve invasion (PLONI) and ocular coat invasion as well as the relationship of the abnormal anterior eye segment enhancement in MRI e. This study's goal is to identify intra-orbital lesions by comparing ultrasound and MRI data.…”

Section: Introductionmentioning

confidence: 99%

Intra-Orbital Lesions (Melanoma/Retinoblastoma) Radiological Findings Correlation on Ultrasound and MRI

Sharif¹,

Shoaib²,

Khalid³

et al. 2022

PJMHS

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Objective: The purpose of this study is to determine intra-orbital lesions by radiological findings correlation on ultrasound and MRI. Study Design: Prospective study Place and Duration: Radiology department of Sindh Govt Hospital Liaquatabad, Karachi and Jinnah hospital, Lahore for the duration from May 2021 to April 2022. Methods: There were 75 patients of both genders presented in this study. Included patients were aged between 2-50 years. A CT scan was performed on all patients with a clinical suspicion of ocular and orbital abnormalities referred from the ophthalmology department. Outcomes among all patients were determined in terms of radiological findings correlated with MRI and ultrasound. SPSS 22.0 was used to analyze complete data. Results: Among 75 cases, there were 43 (57.3%) males and 27 (42.7%) were males. Mean age of the patients was 21.8±4.42 years. Majority of the cases 70 (93.3%) were non traumatic and 5 (6.7%) cases were traumatic. Among 70 cases of non-traumatic lesions, the most common disease was neoplasm found in 32 (45.7%) cases, followed by infective and inflammatory lesions in 22 (31.4%) cases. We found that retinoblastoma was the most common non-traumatic lesion in 21 (30%) cases followed by endocrine orbitopathy and orbital cellulitis. Among 5 cases of traumatic lesions, frequency of fractures were 4 (80%), preseptal soft tissue swelling was found in 3 (60%) cases and retained foreign body (orbital and lid) in 2 (40%) cases. Conclusion: CT is used to diagnose lesions, plan surgery, and track patients with ocular and orbital diseases. MDCT is superior for bone assessment, calcification detection, and determining lesion site, extent, and configuration. MDCT is suitable for evaluating ocular and orbital lesions. Keywords: CT, Ultrasound, MRI, Orbital lesions, Ocular lesions

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3D turbo field echo with diffusion-sensitized driven-equilibrium preparation technique (DSDE-TFE) versus echo planar imaging in evaluation of diffusivity of retinoblastoma

Cited by 6 publications

References 18 publications

A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features

A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features

High Resolution MR Imaging guidelines in retinoblastoma: prospective study correlated with histopathological results

Intra-Orbital Lesions (Melanoma/Retinoblastoma) Radiological Findings Correlation on Ultrasound and MRI

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