3D type I collagen environment leads up to a reassessment of the classification of human macrophage polarizations

Court, Magali; Malier, Marie; Millet, Arnaud

doi:10.1016/j.biomaterials.2019.04.018

Cited by 30 publications

(27 citation statements)

References 46 publications

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“…Culture conditions are used to mimic the in vivo situations. This may be achieved through 3dimensional cultures reflecting the in vivo microenvironment with extracellular matrix interactions (52). In vitro models of resolution have been also set-up with sequential exposure to a complex mixture of factors (i.e., chemokine, bacterial vesicles, and cytokines) (53).…”

Section: Discussionmentioning

confidence: 99%

Toward the Characterization of Human Pro-Resolving Macrophages?

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Toward the Characterization of Human Pro-Resolving Macrophages?

et al. 2020

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“…Long term studies (days or weeks) will increase the significance impact and enhance translational possibilities. Growing evidence points towards a key role of the extracellular matrix in the modulation of the potency of immune cells [52,69,[121][122][123]. Traditional 2D cell culture plastics Growing evidence points towards a key role of the extracellular matrix in the modulation of the potency of immune cells [52,69,[121][122][123].…”

Section: Technological Advances For Future Microgravity Researchmentioning

confidence: 99%

May the Force Be with You (Or Not): The Immune System under Microgravity

ElGindi

Sapudom

Ibrahim

et al. 2021

Cells

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All terrestrial organisms have evolved and adapted to thrive under Earth’s gravitational force. Due to the increase of crewed space flights in recent years, it is vital to understand how the lack of gravitational forces affects organisms. It is known that astronauts who have been exposed to microgravity suffer from an array of pathological conditions including an impaired immune system, which is one of the most negatively affected by microgravity. However, at the cellular level a gap in knowledge exists, limiting our ability to understand immune impairment in space. This review highlights the most significant work done over the past 10 years detailing the effects of microgravity on cellular aspects of the immune system.

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“…329 In a more recent study, Court and colleagues made use of 3D collagen type I hydrogels and showed that the hydrogel differentially modulated human macrophage polarization as compared to 2D culture. 330 Collectively, these studies highlight the tight interplay between matrix cues and macrophage phenotype, mandating careful attention to how macrophages are cultured in vitro for tumor modeling. In this regard, tunable hydrogel systems enable investigations into how biochemical and mechanical cues in the TME influence macrophage polarization and its interactions with cancer and stromal cells.…”

Section: Reviewmentioning

confidence: 99%