3D visualization of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast

Lewis, Rohan M.; Baskaran, Harikesan; Green, Jools; Tashev, Stanimir Asenov; Paleologou, Eleni; Lofthouse, Emma M.; Cleal, Jane K.; Page, Anton; Chatelet, David S.; Goggin, Patricia; Sengers, Bram G.

doi:10.1016/j.isci.2022.105453

Cited by 14 publications

(2 citation statements)

References 33 publications

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“…More recently, it has been shown that the syncytiotrophoblast layer contains trans‐syncytial nanopores which increase molecular diffusion across this barrier. [ 88 ] As a result, the multilayered undifferentiated PSC culture should be a valid model to represent early pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Modeling the Progression of Placental Transport from Early‐ to Late‐Stage Pregnancy by Tuning Trophoblast Differentiation and Vascularization

Kouthouridis,

Sotra,

Khan

et al. 2023

Adv Healthcare Materials

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The early‐stage placental barrier is characterized by a lack of fetal circulation and by a thick trophoblastic barrier, whereas the later‐stage placenta consists of vascularized chorionic villi encased in a thin, differentiated trophoblast layer, ideal for nutrient transport. In this work, predictive models of early‐ and late‐stage placental transport are created using blastocyst‐derived placental stem cells (PSCs) by modulating PSC differentiation and model vascularization. PSC differentiation results in a thinner, fused trophoblast layer, as well as an increase in human chorionic gonadotropin secretion, barrier permeability, and secretion of certain inflammatory cytokines, which are consistent with in vivo findings. Further, gene expression confirms this shift toward a differentiated trophoblast subtype. Vascularization results in a molecule type‐ and size‐dependent change in dextran and insulin permeability. These results demonstrate that trophoblast differentiation and vascularization have critical effects on placental barrier permeability and that this model can be used as a predictive measure to assess fetal toxicity of xenobiotic substances at different stages of pregnancy.

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Section: Discussionmentioning

confidence: 99%

Modeling the Progression of Placental Transport from Early‐ to Late‐Stage Pregnancy by Tuning Trophoblast Differentiation and Vascularization

Kouthouridis,

Sotra,

Khan

et al. 2023

Adv Healthcare Materials

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“…Recent proof of trans-syncytial nanopores in the human placenta demonstrated that potentially harmful molecules can cross the placenta through paracellular diffusion and adversely affect fetal development ( Lewis et al, 2022 ).…”

Section: Pregnancy-related Immune Effects On the Maternal Organismmentioning

confidence: 99%

Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledge

Manti,

Spoto,

Nicotera

et al. 2024

Front. Neurosci.

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Brain development is a complex process that begins during pregnancy, and the events occurring during this sensitive period can affect the offspring’s neurodevelopmental outcomes. Respiratory viral infections are frequently reported in pregnant women, and, in the last few decades, they have been related to numerous neuropsychiatric sequelae. Respiratory viruses can disrupt brain development by directly invading the fetal circulation through vertical transmission or inducing neuroinflammation through the maternal immune activation and production of inflammatory cytokines. Influenza virus gestational infection has been consistently associated with psychotic disorders, such as schizophrenia and autism spectrum disorder, while the recent pandemic raised some concerns regarding the effects of severe acute respiratory syndrome coronavirus 2 on neurodevelopmental outcomes of children born to affected mothers. In addition, emerging evidence supports the possible role of respiratory syncytial virus infection as a risk factor for adverse neuropsychiatric consequences. Understanding the mechanisms underlying developmental dysfunction allows for improving preventive strategies, early diagnosis, and prompt interventions.

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Biological evaluation of folic acid functionalized nano-zeolitic imidazolate framework-8 for cancer therapy

Yong,

Malek,

Asmawi

et al. 2024

Colloid Polym Sci

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3D visualization of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast

Cited by 14 publications

References 33 publications

Modeling the Progression of Placental Transport from Early‐ to Late‐Stage Pregnancy by Tuning Trophoblast Differentiation and Vascularization

Modeling the Progression of Placental Transport from Early‐ to Late‐Stage Pregnancy by Tuning Trophoblast Differentiation and Vascularization

Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledge

Biological evaluation of folic acid functionalized nano-zeolitic imidazolate framework-8 for cancer therapy

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