3D vocal power Doppler sonography for the estimation of tumor volume and vascularization in stage IB1 cervical cancer

Diamantopoulos, Dionysios; Theodora, Mariana; Semertzidou, Anita; Pappa, Kalliopi I.; Antsaklis, Panagiotis; Sindos, Michael; Rodolakis, Alexandros; Kalmantis, K

doi:10.1007/s00404-018-4842-1

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…The increase of the vascular malformation rate causes significant changes in the hemodynamics of patients. However, the analysis of ultrasonic indicators of patients has a number of limitations in the diagnosis of cervical cancer ( 23 ), because benign lesions of the cervix may cause significant changes of regional blood parameters as well. Consequently, if an ultrasound is the only instrument used, it can easily result in false positives in clinical diagnoses.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic significance of a color Doppler ultrasound combined with serum CXCL16 and E-cad in cervical cancer

Wang¹,

Gao²,

Zhu³

et al. 2021

Transl Cancer Res TCR

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Background: The use of effective non-invasive diagnostic markers in the early stage of cervical cancer is lacking currently. This study sought to investigate the value of color Doppler ultrasound combined with serum CXC chemokine ligand-16 (CXCL16) and epithelial cadherin (E-cad) levels in diagnosing cervical cancer.Methods: Two hundreds cervical cancer patients admitted in our hospital between May 2018 and April 2020 were selected as the observation group. The control group included 100 healthy participants. The ultrasound parameters, and the serum CXCL16 and E-cad levels between the two groups and patients at different pathological stages were compared. The correlations between disease progress and ultrasound and serological indexes were analyzed. The diagnostic efficiency of an ultrasound and measures of serum CXCL16 and E-cad levels were compared as well.Results: The peak systolic velocity (PSV) of the observation group was significantly higher than that of the control group (P<0.05). In case of the resistance index (RI), the results were the opposite to the PSV (P<0.05). The PSV (P<0.05) and RI (P<0.05) were significantly different among different pathological stages. The serum CXCL16 (P<0.05) and E-cad (P<0.05) levels of participants in the observation group were significantly higher than those of patients in the control group. A pairwise comparison showed that the serum CXCL16 and E-cad levels increased significantly as the pathological stages of the cancer progressed.The diagnosis and disease progression of cervical cancer were positively correlated with PSV, CXCL16, and E-cad levels, and negatively correlated with the RI. Combining an ultrasound diagnosis with serum CXCL16 and E-cad levels had significantly higher diagnostic sensitivity than that of any individual indicator in patients with cervical cancer. The curve analysis showed that the cut-off values of PSV, the RI, CXCL16 and E-cad were 14.25, 0.50, 40.15 ng/mL and 85.36 pmmol/L, respectively. Conclusions:The sensitivity of color Doppler ultrasound combined with serum CXCL16 and E-cad levels in the diagnosis of cervical cancer is high. Thus, it is recommended that it be used in clinics.

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Section: Discussionmentioning

confidence: 99%

Diagnostic significance of a color Doppler ultrasound combined with serum CXCL16 and E-cad in cervical cancer

Wang¹,

Gao²,

Zhu³

et al. 2021

Transl Cancer Res TCR

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show abstract

“…For evaluating the tumor's volume and intra-tumoral vascularization, the study enrolled 27 patients, with cervical cancer and stage 1B1 disease, who have an initial 2D ultrasound examination and followed by 3D volumes of the cervix. The Virtual Organ Computer Aided Analysis (VOCAL) program was used to calculate the tumor volume and vascularization [23]. For tumors equal or smaller than 2.5 cm3 with linear vascularity, a significant superiority of 2D ultrasound over 3D VOCAL-PD was demonstrated; for larger tumor volume with complex vascularization, a superiority of 3D VOCAL-PD was revealed [23].…”

Section: Local Staging Of Cervical Cancermentioning

confidence: 99%

“…The Virtual Organ Computer Aided Analysis (VOCAL) program was used to calculate the tumor volume and vascularization [23]. For tumors equal or smaller than 2.5 cm3 with linear vascularity, a significant superiority of 2D ultrasound over 3D VOCAL-PD was demonstrated; for larger tumor volume with complex vascularization, a superiority of 3D VOCAL-PD was revealed [23]. Therefore, 3-D VOCAL-PD is superior to 2D ultrasound for calculating tumor volume and vascularization when tumor is more than 2.5 cm3 and show a complex vascularization in women with stage 1B1 cervical cancer [23].…”

Section: Local Staging Of Cervical Cancermentioning

confidence: 99%

Updated applications of Ultrasound in Uterine Cervical Cancer

Hsiao¹,

Yang²,

Chen³

et al. 2021

J. Cancer

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Cervical cancer is a common gynecologic malignancy worldwide. It is the fourth for both incidence and mortality. For cervical cancer, imaging and pathology assessments are incorporated in the revised 2018 Federation of Gynecology and Obstetrics (FIGO) staging system. Uses of imaging techniques for the pre-treatment work-up of cervical cancer have been increasing. Among imaging techniques for the evaluation of cervical cancer, ultrasound is cheaper, faster and widely available than other imaging techniques such as computed tomography (CT) or magnetic resonance imaging (MRI). Advanced technique in ultrasound, such as three-dimension (3D) ultrasound and color Doppler, have improved the clinical application of ultrasound in cervical cancer. Ultrasound may provide highly accurate information on detecting tumor presence and evaluating local tumor extent if performed by ultrasound-trained gynecologists; the experience of readers is also critical for correct pretreatment staging and assessment of response to treatment. Sonographic images could be useful to predict response of neoadjuvant chemotherapy, radiotherapy, chemotherapy and concurrent chemoradiotherapy in patients with cervical cancer. This review article attempted to present the most updated specific applications of ultrasound in cervical cancer.

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Based on 3D-PDU and clinical characteristics nomogram for prediction of lymph node metastasis and lymph-vascular space invasion of early cervical cancer preoperatively

Dong,

Peng,

Feng

et al. 2024

BMC Women's Health

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3D vocal power Doppler sonography for the estimation of tumor volume and vascularization in stage IB1 cervical cancer

Abstract: 3-D VOCAL-PD is extremely accurate and superior to 2D ultrasound for the estimation of tumor volume and vascularization when it is more than 2.5 cm and has a complex vascularization in patients with stage 1B1 cervical cancer.

Cited by 4 publications

References 18 publications

Diagnostic significance of a color Doppler ultrasound combined with serum CXCL16 and E-cad in cervical cancer

Diagnostic significance of a color Doppler ultrasound combined with serum CXCL16 and E-cad in cervical cancer

Updated applications of Ultrasound in Uterine Cervical Cancer

Based on 3D-PDU and clinical characteristics nomogram for prediction of lymph node metastasis and lymph-vascular space invasion of early cervical cancer preoperatively

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