The recent decline in available personal protective equipment (PPE) due to the novel coronavirus (COVID-19) pandemic has given rise to a host of three-dimensional (3D) printed prototypes for facemask and respirator units. Many of these models have been made open access and publicly available for printing and use, and have been promoted by various media outlets. Although these desktop 3D printing measures have provided a possible venue for success in providing homemade and cost-effective PPE to health care workers, the rapid dissemination of these prototypes has been performed without reproducible methods of standardization and vetted safety in use. Although these methods have not been sanctioned by authoritative organizations as viable production approaches to address the PPE shortage, a concerted effort within the 3D printing community to adhere to scientific methodology and organized research efforts has the potential to provide a solution to this critical issue.