3D ZnIn2S4 nanosheets decorated ZnCdS dodecahedral cages as multifunctional signal amplification matrix combined with electroactive/photoactive materials for dual mode electrochemical – photoelectrochemical detection of bovine hemoglobin

Shang, Hongyuan; Xu, Hui; Jin, Liujun; Wang, Cheng; Chen, Chunyan; Song, Tongxin; Du, Yukou

doi:10.1016/j.bios.2020.112202

Cited by 84 publications

(37 citation statements)

References 37 publications

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“…Chen et al 41 have demonstrated that the catalytic performance of nano-sheets materials is better than that of nano-wires and cubes. Shang et al 11 also demonstrated the outstanding electrocatalytic performances of Pd-pm bimetallic catalysts are of the 3D flower-like nanostructures assembled with ultrathin nanosheets.…”

Section: Resultsmentioning

confidence: 99%

Self-Assembled Co₃O₄/GO Composites for Excellent Electrochemical Detection of Heavy-Metal Ions

Hao

Zhang

Wang

et al. 2021

J. Electrochem. Soc.

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Recently, electrochemical sensors have been applied for the detection of heavy metal ions. The modifier on the electrochemical electrode is the key factor for enhanced performance. Modification by combining metal oxide nanomaterials with good adsorption property and graphene oxide (GO) with good conductivity can construct a useful sensing interface to detect heavy metal ions. Here, the effects of structures and morphologies of Co 3 O 4 /GO composite modifiers on the electrochemical detection performance were studied. The results show that Co 3 O 4 /GO composite with holey nano-sheets of pure Co 3 O 4 on lamella GO substrate had the best electrochemical performance for their large active sites and enhanced ion and charge transports. The limits of detection of the electrochemical sensors based on developed Co 3 O 4 /GO composite to Cd 2+ and Pb 2+ were calculated as 57 and 29.4 nM, respectively, which are lower than the guideline values recommended by the World Health Organization for drinking water. Furthermore, the designed sensor also showed excellent stability, selectivity, and acceptable reproducibility and reliablity. The results indicate that Co 3 O 4 /GO composite with holey layer structures as a promising electrode modifier could be potentially applied in the electrochemical detection of heavy metal ions on-site.

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Section: Resultsmentioning

confidence: 99%

Self-Assembled Co₃O₄/GO Composites for Excellent Electrochemical Detection of Heavy-Metal Ions

Hao

Zhang

Wang

et al. 2021

J. Electrochem. Soc.

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“…To solve the above problems, dual-mode sensing platforms have recently been developed based on two different response mechanisms and relatively independent signal transduction, such as EC–PEC, ECL–FL, and PEC–CL . The dual-mode sensing strategies not only possess the inherent characteristics of each response mode but also offer the mutual verification of the assay results obtained from different modes, which will effectively improve the accuracy and reliability of detection. − Among these developed dual-mode sensing platforms, EC–PEC dual-mode assay has received wide attention due to the following merits, such as fast response, high sensitivity, good selectivity, easy portability, and low cost. , Interestingly, the EC–PEC dual-mode platform needs only one electrochemical instrument, but has two signal readouts, providing the sensing platform with the advantages of a simple sensing structure.…”

Section: Introductionmentioning

confidence: 99%

“…11−13 Among these developed dual-mode sensing platforms, EC−PEC dual-mode assay has received wide attention due to the following merits, such as fast response, high sensitivity, good selectivity, easy portability, and low cost. 14,15 Interestingly, the EC−PEC dual-mode platform needs only one electrochemical instrument, but has two signal readouts, providing the sensing platform with the advantages of a simple sensing structure.…”

Section: ■ Introductionmentioning

confidence: 99%

Sensitive Dual-Mode Biosensors for CYFRA21-1 Assay Based on the Dual-Signaling Electrochemical Ratiometric Strategy and “On–Off–On” PEC Method

et al. 2021

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Herein, an electrochemical (EC)–photoelectrochemical (PEC) dual-mode biosensor was constructed for cytokeratin 19 fragment 21-1 (CYFRA21-1) assay based on the dual-signaling electrochemical ratiometric strategy and “on–off–on” PEC method. The indium tin oxide (ITO) electrode was modified by 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA)@C60 and gold nanoparticles (Au NPs), and the double-stranded DNA composed of thiol/methylene blue (MB)-labeled single-stranded DNA (ssDNA) (S0-MB) and antibody/ferrocene (Fc)-labeled ssDNA (Ab1-S1-Fc) was immobilized on the Au NPs/PTCDA@C60/ITO electrode via the Au–S bond between Au NPs and thiol of S0-MB. With the help of another antibody-labeled ssDNA (Ab2-S2), the presence of CYFRA21-1 triggered a typical antigen–antibody sandwich immune reaction (Ab1, CYFRA21-1, and Ab2) and proximity hybridization between Ab1-S1-Fc and Ab2-S2. This caused the release of Ab1-S1-Fc from the modified electrode and the change of S0-MB to a hairpin structure, resulting in a decrease (an increase) of the oxidation peak current of Fc (MB) and an increase of the photocurrent due to the enhancing (inhibiting) effect of MB (Fc) on the photoelectric performance of the Au NPs/PTCDA@C60/ITO electrode. Thus, CYFRA21-1 was detected by the developed EC–PEC dual-mode sensing platform sensitively, and the linear response ranges of 0.001–40 ng/mL with a detection limit of 0.3 pg/mL for the EC technique and 0.0001–4 ng/mL with a detection limit of 0.03 pg/mL for the PEC method were obtained. Furthermore, by changing the specific antibodies of disease-related biomarkers, the developed dual-mode biosensing platform could be readily extended to detect other antigens, implying its great potential applications in biological analysis and early disease diagnosis.

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“…22,23 In these dualmode biosensing methods that have been reported, EC−PEC dual-mode analysis has attracted widespread concern owing to its easy portability, low cost, fast response, and so forth. 13,24 Moreover, the EC−PEC analysis only demands one electrochemical apparatus but possesses two types of readout signals, which makes the biosensing platform have the advantage of a simple detecting structure.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In order to resolve the abovementioned issues, dual-mode biosensing methods have already been developed recently for miRNA assay based on two types of response mechanisms and comparatively distinct signaling transductions, such as EC–PEC, , PEC–colorimetry (CL), , SERS–EC, SERS–FL, , FL–CL, and circular dichroism–luminescence . The dual-mode biosensing strategy not only has unique properties of each mode but also offers reciprocal authentication of detection results in various modes, effectively increasing the accuracy and confidence level of assay. , In these dual-mode biosensing methods that have been reported, EC–PEC dual-mode analysis has attracted widespread concern owing to its easy portability, low cost, fast response, and so forth. , Moreover, the EC–PEC analysis only demands one electrochemical apparatus but possesses two types of readout signals, which makes the biosensing platform have the advantage of a simple detecting structure.…”

Section: Introductionmentioning

confidence: 99%

Highly Selective and Sensitive microRNA-210 Assay Based on Dual-Signaling Electrochemical and Photocurrent-Polarity-Switching Strategies

Zhang

Liu

et al. 2021

Anal. Chem.

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Highly sensitive and selective microRNA (miRNA) assay is of great significance for disease diagnosis and therapy. Herein, a magnetic-assisted electrochemistry (EC)−photoelectrochemistry (PEC) dual-mode biosensing platform was developed for miRNA-210 detection based on dual-signaling EC and photocurrentpolarity-switching PEC strategies. Porous magnetic Fe 3 O 4 octahedra with a large surface area were synthesized by calcining Fe-based metal−organic frameworks. Subsequently, the magnetic photoelectric materials (Fe 3 O 4 @CdS) were developed by the successive ionic layer adsorption and reaction method in Cd 2+ and S 2− solutions. Then, the self-assembled DNA nanoprisms contained three thiols/hanging arms that could capture miRNA-210 efficiently and were anchored to the Fe 3 O 4 @CdS octahedra via the Cd−S bond. When miRNA-210 was present, the double-stranded DNA concatemers [the self-assembled duplex helixes based on a pair of methylene blue (MB)-labeled single-stranded DNAs (AP1 and AP2) through the hybridization chain reaction and then intercalated with adriamycin (Dox) into their grooves] were connected with the Fe 3 O 4 @CdS-DNA nanoprisms. MB and Dox not only acted as the electrochemical probes but also synergistically switched the photocurrent polarity of the Fe 3 O 4 @CdS octahedra. Thus, miRNA-210 was assayed sensitively and selectively via the proposed EC−PEC dual-mode biosensing platform. Additionally, the abovementioned recognition steps occurred in a homogeneous system, and the effects of the impurities and interferences on the miRNA-210 assay could be easily avoided by magnetic separation due to the good magnetic properties of Fe 3 O 4 octahedra. The proposed EC−PEC dual-mode biosensing platform showed a wide range of potential applications in bioanalysis and early diagnosis of disease.

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3D ZnIn2S4 nanosheets decorated ZnCdS dodecahedral cages as multifunctional signal amplification matrix combined with electroactive/photoactive materials for dual mode electrochemical – photoelectrochemical detection of bovine hemoglobin

Cited by 84 publications

References 37 publications

Self-Assembled Co₃O₄/GO Composites for Excellent Electrochemical Detection of Heavy-Metal Ions

Self-Assembled Co₃O₄/GO Composites for Excellent Electrochemical Detection of Heavy-Metal Ions

Sensitive Dual-Mode Biosensors for CYFRA21-1 Assay Based on the Dual-Signaling Electrochemical Ratiometric Strategy and “On–Off–On” PEC Method

Highly Selective and Sensitive microRNA-210 Assay Based on Dual-Signaling Electrochemical and Photocurrent-Polarity-Switching Strategies

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3D ZnIn2S4 nanosheets decorated ZnCdS dodecahedral cages as multifunctional signal amplification matrix combined with electroactive/photoactive materials for dual mode electrochemical – photoelectrochemical detection of bovine hemoglobin

Cited by 84 publications

References 37 publications

Self-Assembled Co3O4/GO Composites for Excellent Electrochemical Detection of Heavy-Metal Ions

Self-Assembled Co3O4/GO Composites for Excellent Electrochemical Detection of Heavy-Metal Ions

Sensitive Dual-Mode Biosensors for CYFRA21-1 Assay Based on the Dual-Signaling Electrochemical Ratiometric Strategy and “On–Off–On” PEC Method

Highly Selective and Sensitive microRNA-210 Assay Based on Dual-Signaling Electrochemical and Photocurrent-Polarity-Switching Strategies

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Product

Resources

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Self-Assembled Co₃O₄/GO Composites for Excellent Electrochemical Detection of Heavy-Metal Ions

Self-Assembled Co₃O₄/GO Composites for Excellent Electrochemical Detection of Heavy-Metal Ions