(3H)-Ketanserin binding and elevated plus-maze behavior after
chronic antidepressant treatment in DSP-4 and P-CPA pretreated
rats: Evidence for partial involvement of 5-HT2A receptors

Skrebuhhova, T.; Allikmets, Lembit; Matto, V.

doi:10.1358/mf.1999.21.7.550112

Methods and Findings in Experimental and Clinical Pharmacology

1999

DOI: 10.1358/mf.1999.21.7.550112

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(3H)-Ketanserin binding and elevated plus-maze behavior after chronic antidepressant treatment in DSP-4 and P-CPA pretreated rats: Evidence for partial involvement of 5-HT2A receptors

T. Skrebuhhova¹,

Lembit Allikmets²,

V. Matto³

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Cited by 9 publications

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The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies

Heesbeen,

van Kampen,

Verdouw

et al. 2024

Psychopharmacology

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Rationale Selective serotonin reuptake inhibitors (SSRIs) are the first choice of treatment for anxiety-like disorders. However, which aspects of anxiety are affected by SSRIs is not yet fully understood. Objective We aimed to systematically review the effect of six clinically effective SSRIs on four aspects of unconditioned anxiety: approach-avoidance behaviour (elevated plus maze), repetitive behaviour (marble burying), distress behaviour (ultrasonic vocalization), and activation of the autonomous nervous system (stress-induced hyperthermia). Methods We identified publications by searching Medline and Embase databases and assessed the risk of bias. A random effects meta-analysis was performed and moderator effects were analysed with Bayesian penalized meta-regression. Results Our search yielded 105 elevated plus maze, 63 marble burying, 11 ultrasonic vocalization, and 7 stress-induced hyperthermia articles. Meta-analysis suggested that SSRIs reduce anxiety-like behaviour in the elevated plus maze, marble burying and ultrasonic vocalization test and that effects are moderated by pre-existing stress conditions (elevated plus maze) and dose dependency (marble burying) but not by duration of treatment or type of SSRI. The reporting quality was low, publication bias was likely, and heterogeneity was high. Conclusion SSRIs seem to reduce a broad range of unconditioned anxiety-associated behaviours. These results should be interpreted with caution due to a high risk of bias, likely occurrence of publication bias, substantial heterogeneity and limited moderator data availability. Our review demonstrates the importance of including bias assessments when interpreting meta-analysis results. We further recommend improving the reporting quality, the conduct of animal research, and the publication of all results regardless of significance.

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The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies

Heesbeen,

van Kampen,

Verdouw

et al. 2024

Psychopharmacology

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Effects of methylphenidate on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)

et al. 2017

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The aim of this study was to assess the effects of the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) on attention in rats as measured using the 5-choice-serial-reaction-time task (5CSRTT) and to investigate whether methylphenidate has effects on DSP4-treated rats. Methylphenidate is a noradrenaline and dopamine reuptake inhibitor and commonly used in the pharmacological treatment of individuals with attention deficit/hyperactivity disorder (ADHD). Wistar rats were trained in the 5CSRTT and treated with one of three doses of DSP4 or saline. Following the DSP4 treatment rats were injected with three doses of methylphenidate or saline and again tested in the 5CSRTT. The treatment with DSP4 caused a significant decline of performance in the number of correct responses and a decrease in response accuracy. A reduction in activity could also be observed. Whether or not the cognitive impairments are due to attention deficits or changes in explorative behaviour or activity remains to be investigated. The treatment with methylphenidate had no beneficial effect on the rats' performance regardless of the DSP4 treatment. In the group without DSP4 treatment, methylphenidate led to a reduction in response accuracy and bidirectional effects in regard to parameters related to attention. These findings support the role of noradrenaline in modulating attention and call for further investigations concerning the effects of methylphenidate on attentional processes in rats.

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Erratum to: Effects of methylphenidate on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)

et al. 2017

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The present study is a part of a large research project investigating the effects of substances used in the treatment of attention deficit hyperactivity disorder on attention in rats. This paper presents the results for methylphenidate in DSP4-treated rats while our findings regarding atomoxetine were published later (Hauser et al. 2017). This reference was not included in the present paper due to the close succession of the two articles' publication.Hauser J, Reissmann A, Sontag TA, Tucha O, Lange KW (2017) Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4). ADHD Atten Deficit Hyperact Disord.

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(3H)-Ketanserin binding and elevated plus-maze behavior after chronic antidepressant treatment in DSP-4 and P-CPA pretreated rats: Evidence for partial involvement of 5-HT2A receptors

Cited by 9 publications

References 0 publications

The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies

The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies

Effects of methylphenidate on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)

Erratum to: Effects of methylphenidate on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)

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