[3H]N-[1-(2-Benzo(b)thiophenyl) cycohexyl]piperidine ([3H]BTCP): a new phencyclidine analog selective for the dopamine uptake complex

N-[1-(2-Benzo[b]Thiophenyl)Cyclohexyl]- Piperidine (BTCP) Exerts Cocaine-Like Actions on Drug-Maintained Responding in Rats

“…The BTCP-induced leftward shift is similar to that induced by higher unit doses of cocaine and, therefore, suggestive of an enhancement of the reinforcing actions of cocaine. BTCP inhibits dopamine reuptake and, in this respect, exerts similar, albeit more potent, pharmacological actions as cocaine (Chaudieu et al 1989;Vignon et al 1988). Moreover, cocaine and BTCP produced identical decreases in self-administration of a cocaine dose on the descending limb of the dose-response function, confirming earlier findings that BTCP and cocaine have similar behavioral actions (French et al 1995;Koek et al 1989;Martin-Fardon et al 1996a).…”

“…Since BTCP is a phencyclidine derivative and has some affinity for the PCP receptor, some of its behavioral actions may be the result of an action at the NMDA receptor. However, while BTCP is a PCP derivative, its predominant pharmacological action is a potent and highly selective inhibition of DA reuptake (Chaudieu et al 1989;Vignon et al 1988), but has only low affinity for the PCP receptor itself. Moreover, in contrast to the non-competitive NMDA antagonists MK-801 and PCP, BTCP does not antagonize NMDA-induced convulsions in mice (Koek et al 1989).…”

“…It is widely accepted that the addictive and reinforcing actions of cocaine are the result of the drug's ability to block the reuptake of dopamine (DA) by inhibiting the dopamine transporter (DAT) and, thereby, increasing DA neurotransmission (Kuhar 1992;Ritz et al 1987;Parsons et al 1998;Woolverton 1992). N-[1-(2-benzo[b]thiophenyl)cyclohexyl] piperidine (BTCP) is a phencyclidine (PCP) derivative that has high affinity for the DAT (Chaudieu et al 1989;Vignon et al 1988) but binds to a different site on the transporter than cocaine (Maurice et al 1991a(Maurice et al ,b, 1993Akunne et al 1994).…”

“…BTCP, like cocaine, inhibits DA uptake (Chaudieu et al 1989;Vignon et al 1988) and is, in fact, one of the most potent inhibitors of DA reuptake known to date (Chaudieu et al 1989). Like cocaine, BTCP increases extracellular DA levels in the striatum and the nucleus accumbens (Martin-Fardon et al 1996a;Maurice et al 1992), and stimulates locomotor activity in rats (Slimani et al 1988) and mice (Ilagouma et al 1993;Koek et al 1989).…”

“…It is widely accepted that the addictive and reinforcing actions of cocaine are the result of the drug's ability to block the reuptake of dopamine (DA) by inhibiting the dopamine transporter (DAT) and, thereby, increasing DA neurotransmission (Kuhar 1992;Ritz et al 1987;Parsons et al 1998;Woolverton 1992). N-[1-(2-benzo[b]thiophenyl)cyclohexyl] piperidine (BTCP) is a phencyclidine (PCP) derivative that has high affinity for the DAT (Chaudieu et al 1989;Vignon et al 1988) but binds to a different site on the transporter than cocaine (Maurice et al 1991a(Maurice et al ,b, 1993Akunne et al 1994).BTCP, like cocaine, inhibits DA uptake (Chaudieu et al 1989;Vignon et al 1988) and is, in fact, one of the most potent inhibitors of DA reuptake known to date (Chaudieu et al 1989). Like cocaine, BTCP increases extracellular DA levels in the striatum and the nucleus accumbens (Martin-Fardon et al 1996a;Maurice et al 1992), and stimulates locomotor activity in rats (Slimani et al 1988) and mice (Ilagouma et al 1993;Koek et al 1989).…”