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Kallepalli, Pramadvara

doi:10.22377/ajp.v12i02.2400

AJP

2018

DOI: 10.22377/ajp.v12i02.2400

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Pramadvara Kallepalli¹

Abstract: Introduction: Felodipine is used for the treatment of hypertension. In the present study a new stability-indicating RP-HPLC method has been established for the determination of Felodipine.in pharmaceutical dosage forms and the method was validated. Material and Methods: Shimadzu Model CBM-20A/20 Alite, UFLC system was used for the assay of Felodipine using a mixture of phosphate buffer (pH 7.0) and acetonitrile (20:80, v/v) as mobile phase with a flow rate of 1.2 ml/min (UV detection at 234 nm). Forced degrada… Show more

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2023

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Cited by 2 publications

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A Review on recent approaches for the use of different Analytical Techniques to Analyze some Calcium Channel Blockers and their Combinations with other Antihypertensive Drugs

Ganorkar,

Kulkarni,

Khiste

2023

CIS

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Background:: Diabetes, high cholesterol, and high blood pressure all considerably raise the risk of cardiovascular disease. When all three of these characteristics occur at once, a metabolic problem is postulated. A combination of antihypertensive, hypolipidemic, and anti-diabetic medications is frequently utilised to treat cardiovascular diseases. While statins (fluvastatin, simvastatin, etc.) are used to lower cholesterol levels, calcium channel blockers (e.g. amlodipine, efonidipine, and azelnidipine, etc.) are used to target the smooth muscles of the heart. Diuretics (e.g. chlortalidone, hydrochlorothiazide, etc.) and angiotensin II receptor antagonist (blockers) are also used to manage high blood pressure. Objective:: The study aimed to review liquid chromatography and related high-performance (HPLC) techniques that have been developed and used for evaluating the above drugs, together with an overview of the research work published in various scientific and drugs-linked journals. Results:: A basic critical investigation of the detailed published information has been completed and the current status of HPLC and related techniques as a percent measure of calcium channel blockers has been examined. Conclusion:: This survey has explored several matrices, including pharmacological products and organic samples, as well as methods for examining direct calcium blockers in them. It also discusses the current state of calcium channel blocker stability investigations. Additionally, it offers scientific approaches for the concurrent estimate of angiotensin II receptor antagonism, diuretics, statins, and beta-blockers with calcium channel blockers.

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A Review on recent approaches for the use of different Analytical Techniques to Analyze some Calcium Channel Blockers and their Combinations with other Antihypertensive Drugs

Ganorkar,

Kulkarni,

Khiste

2023

CIS

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Felodipine-Review of Analytical Methods Developed for Pharmaceutical Dosage Forms and Biological Fluids

MALLI,

KUMAR,

VERMA

2023

Int J App Pharm

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Felodipine (FDP) is a vascular selective L-type calcium channel blocker, in hypertension patients FDP significantly lowers systolic and diastolic blood pressure (BP). It is a lipophilic drug molecule that contains a dihydropyridine ring responsible to show pharmacological activity, it is mainly used to control and prevent essential hypertension. This review article provides a summary of various analytical techniques for determining felodipine in pure form, pharmaceutical formulations, and biological fluids. Various analytical techniques are developed and validated, such as ultraviolet/visible spectrophotometry, high-performance liquid chromatography (HPLC), high-performance thin layer chromatography (HPTLC), and bioanalytical techniques. Estimated validation parameters such as linearity, LOD (Limit of Detection), and LOQ (Limit of Quantification) are discussed for each method. The wavelength of detection (λmax), mobile phase, columns, flow rate, retention time (Rt) and sample preparation techniques are all important quality elements for calculating Felodipine via analytical procedures.

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Cited by 2 publications

References 5 publications

A Review on recent approaches for the use of different Analytical Techniques to Analyze some Calcium Channel Blockers and their Combinations with other Antihypertensive Drugs

A Review on recent approaches for the use of different Analytical Techniques to Analyze some Calcium Channel Blockers and their Combinations with other Antihypertensive Drugs

Felodipine-Review of Analytical Methods Developed for Pharmaceutical Dosage Forms and Biological Fluids

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