Untitled

Abstract

The number of Proton Pump Inhibitor (PPI) users has grown since the last decade. This greater use has come together with its inappropriate prescription, which is a result of its effectiveness and good tolerance. However, there is overuse and inappropriate use with excessive dose and duration. The literature reveals that long-term PPI use has side effects such as pneumonia, gastrointestinal cancer, dementia. These side effects need to be proved and have weak association. Further studies are necessary to elucidate them. This study will ascertain the relationship of PPIs and their long-term collateral effects. In this study, reviews from the last five years addressing the long-term use of PPIs and their possible side effects were sought in indexed databases (PubMed, SciELO and Lilacs). Fourteen articles and 21 relevant side effects were analyzed. The association with most of the reported side effects such as cancer, chronic kidney disease, dementia and communityacquired pneumonia (CAP) is denied. There was a positive association with gastric polyps, magnesium deficiency and acute interstitial nephritis. The side effects are widely spread and even if there is a positive association with some of them, the use of PPIs is likely safe, as the association was negative for more debilitating collateral effects.