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Abstract

Oral cancer is the sixth leading cancer globally and the leading carcinoma in the Indian subcontinent. The relatively high incidence is due to usage of tobacco, and exposure to carcinogens are frontrunners of oxidative stress-induced DNA damage. The practice of chemopreventive agents is considered to be alternative oral carcinoma. A study on novel natural chemo preventive agent-Indigofera Aspalathoides was undertaken to evaluate its preventive chemo effect. Male Syrian Golden hamsters aged 10-12 weeks and weighing about 80-100 g were selected. Group 1were control; Group II hamsters were given Intragastric administration of ethanolic fraction of IA; Groups III had Intragastric administration of chloroform fraction of IA, Group IV had Intragastric administration of E IA + DMBA ,Group V had DMBA + Intragastric administration of CIA, and Group VI with DMBA alone. Total antioxidant power and extend of lipid peroxidation was measured by gold standard methods. Our study suggests that both EIA and CIA had a significant anticancer and preventive chemo effect against squamous cell carcinoma. Elevation in the extent of lipid peroxidation and the decrease in the levels of antioxidants were observed in the plasma of DMBA alone treated animals. This study suggests that elevation in the extent of lipid peroxidation and the decrease in the levels of antioxidants were observed in the plasma of DMBA alone treated animals. INTRODUCTION:Oral cancer refers to a subgroup of head and neck malignancies that develop at the lips, tongue, salivary gland, gingiva, floor of the mouth, oropharynx, buccal surfaces and QUICK RESPONSE CODE