3PC-025 Optimisation of compounding organisation after implementing a robotic system for automated preparation of oncologic drugs

Abstract

an extraction of the software was done to study the forced steps (the steps refused by the software but accepted by the pharmacist because of the correct volume read) over a period of 6 months. Results The metrological tests enable to qualify the balances. The bias of the weighing scales fluctuates between 0.94% and 4.40%. Over 6 months, 15 227 preparations were realised with a total of 1 89 334 steps including 49 180 weighing steps. Among those, there were 2023 forced steps (4.1%). The most forced cytotoxic molecules were identified. The two most forced stages were the weighing of the syringe with cytotoxic (41%) and of the final pouch (23%). The 50 ml syringe is responsible for 41% of this forced stage and, in 85% of the cases, it is because the volume to collect has a decimal value. Conclusion Concerning the sensitivity, a method is elaborated to determine the rate of the false negatives with a fake cytotoxic preparations plan and calculated weighing errors. Our method validation plan is complete with the validation of the two components: precision scale and software. REFERENCES AND/OR ACKNOWLEDGEMENTSNo conflict of interest.

Automated compounding technology and workflow solutions for the preparation of chemotherapy: a systematic review

“…Both robotic and workflow compounding systems were associated with reductions in annual costs compared with manual compounding16 19 32 38 and data from recently published studies suggest that these reductions may result from improvements in staff utilisation and supply cost savings with automated versus manual preparation 44–46. However, a cost-volume analysis suggests that the higher annual fixed costs of robotic systems results in a high breakeven point in terms of the number of preparations required (34 000 preparations annually) in return for the initial investment 19.…”

Increasing pharmacy productivity and reducing medication turnaround times in an Italian comprehensive cancer center by implementing robotic chemotherapy drugs compounding

“…At this regard, Silimbani et al demonstrated that the transfer of 7,600 infusion treatments from manual to robotic production freed 1.0 FTE a year for reallocation in other pharmacy activities. 22 To serve the high number of outpatients and meet their needs for same-day compounding of prescriptions, oncology pharmacy department needs to adopt the just-in-time approach of compounding, which requires organization that reduces as much as possible the outpatient's waiting time. For this reason, with the increase of the daily workload, pharmacies need to reorganize so as to optimize the process of validation, compounding, and delivery to reduce the MTAT, defined as the time between drug prescription and administration.…”

“…demonstrated that the transfer of 7,600 infusion treatments from manual to robotic production freed 1.0 FTE a year for reallocation in other pharmacy activities. 22…”

“…Robotic systems offer advantages in terms of accuracy with the detection of possible compounding errors, fast and fully traceability of the process and frees pharmacy staff to handle hazardous drugs with repetitive strain injuries. [20][21][22] In May 2018, our cancer center began a collaboration with two satellite regional hospitals to centralize the preparation of their antineoplastic drugs. The pharmacy department had to adopt a number of organizational interventions to meet this escalating demand in chemotherapies, without increasing the medication turnaround times for outpatients (MTAT).…”

“…Robotic systems offer advantages in terms of accuracy with the detection of possible compounding errors, fast and fully traceability of the process and frees pharmacy staff to handle hazardous drugs with repetitive strain injuries. 20–22…”