3T sodium MR imaging in Alzheimer’s disease shows stage-dependent sodium increase influenced by age and local brain volume

Haeger, Alexa; Boumezbeur, Fawzi; Bottlaender, Michel; Rabrait-Lerman, Cécile; Lagarde, Julien; Mirzazade, Shahram; Krahe, Janna; Hohenfeld, Christian; Sarazin, Marie; Schulz, Jörg B.; Romanzetti, Sandro; Reetz, Kathrin

doi:10.1016/j.nicl.2022.103274

Cited by 3 publications

(8 citation statements)

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“…The mean sodium concentration in vitreous humor of AGRdm (145 mmol/L) was used as internal reference to scale all sodium reconstructions from arbitrary units to mmol/L. In the absence of external sodium concentration calibration standards, sodium concentration ratios between cortical GM and WM, and between cortical GM and a brainstem ROI eroded by 4 mm were also calculated, similar to the relative regional sodium quantification proposed in Reference 7.…”

Section: Methodsmentioning

confidence: 99%

“…3. "Anatomically guided" reconstruction of the combined first and second echo dataset including joint signal decay estimation and modeling (AGRdm) by solving equation ( 9) using the structural dTV prior * and a mono-exponential for signal decay during readout in (7) for u and r.…”

Section: Simulation Experimentsmentioning

confidence: 99%

“…Changes in tissue sodium concentration have been shown to provide physiologically relevant information for challenging brain pathologies such such as brain tumors, 1,2 stroke, 3,4 and Alzheimer's disease. [5][6][7] For an in-depth overview on the state-of-the-art of in vivo MR sodium imaging techniques and applications, we refer to the recent reviews by Madelin, 8 Sha, 9 Thulborn 10 and Hagiwara. 11 Despite its unique potential for providing non-invasive and physiologically relevant information, the development and clinical acceptance of sodium MRI has been hampered compared to proton MRI, owing to the unique data acquisition challenges posed by the NMR properties of the 23 Na nucleus, namely:…”

Section: Introductionmentioning

confidence: 99%

“…Sodium‐23 ( 23 Na) is the second most abundant MR‐active nucleus in the human body and plays a crucial role in ion homeostasis and cell viability. Changes in tissue sodium concentration have been shown to provide physiologically relevant information for challenging brain pathologies such such as brain tumors, 1,2 stroke, 3,4 and Alzheimer's disease 5–7 . For an in‐depth overview on the state‐of‐the‐art of in vivo MR sodium imaging techniques and applications, we refer to the recent reviews by Madelin, 8 Sha, 9 Thulborn 10 and Hagiwara 11 .…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the images that are commonly obtained, suffer from spatial blurring beyond that corresponding to the nominal spatial resolution of the acquired spatial frequency values (i.e.,

1/2{k}_{\mathrm{max}}

) due to the fast decay of the signal during readout. As discussed in References 7 and 12, a direct consequence of the rather low resolution of sodium images are severe partial volume effects (PVEs) that make accurate quantification of local sodium concentration difficult. This is especially the case, when changes in local sodium concentration in the brain are accompanied by atrophy, necessitating advanced methods for partial volume correction.…”

Section: Introductionmentioning

confidence: 99%

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Resolution enhancement, noise suppression, and joint T2* decay estimation in dual‐echo sodium‐23 MR imaging using anatomically guided reconstruction

Schramm,

Filipovic,

Qian

et al. 2023

Magnetic Resonance in Med

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PurposeSodium MRI is challenging because of the low tissue concentration of the 23Na nucleus and its extremely fast biexponential transverse relaxation rate. In this article, we present an iterative reconstruction framework using dual‐echo 23Na data and exploiting anatomical prior information (AGR) from high‐resolution, low‐noise, 1H MR images. This framework enables the estimation and modeling of the spatially varying signal decay due to transverse relaxation during readout (AGRdm), which leads to images of better resolution and reduced noise resulting in improved quantification of the reconstructed 23Na images.MethodsThe proposed framework was evaluated using reconstructions of 30 noise realizations of realistic simulations of dual echo twisted projection imaging (TPI) 23Na data. Moreover, three dual echo 23Na TPI brain datasets of healthy controls acquired on a 3T Siemens Prisma system were reconstructed using conventional reconstruction, AGR and AGRdm.ResultsOur simulations show that compared to conventional reconstructions, AGR and AGRdm show improved bias‐noise characteristics in several regions of the brain. Moreover, AGR and AGRdm images show more anatomical detail and less noise in the reconstructions of the experimental data sets. Compared to AGR and the conventional reconstruction, AGRdm shows higher contrast in the sodium concentration ratio between gray and white matter and between gray matter and the brain stem.ConclusionAGR and AGRdm generate 23Na images with high resolution, high levels of anatomical detail, and low levels of noise, potentially enabling high‐quality 23Na MR imaging at 3T.

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Section: Methodsmentioning

confidence: 99%

Section: Simulation Experimentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Moreover, the images that are commonly obtained, suffer from spatial blurring beyond that corresponding to the nominal spatial resolution of the acquired spatial frequency values (i.e.,

1/2{k}_{\mathrm{max}}

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Resolution enhancement, noise suppression, and joint T2* decay estimation in dual‐echo sodium‐23 MR imaging using anatomically guided reconstruction

Schramm,

Filipovic,

Qian

et al. 2023

Magnetic Resonance in Med

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3T sodium-MRI as predictor of neurocognition in nondemented older adults: a cross sectional study

Lui,

Venkatraman,

Finch

et al. 2024

Brain Communications

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Dementia is a burgeoning global problem. Novel magnetic resonance imaging (MRI) metrics beyond volumetry may bring new insight and aid clinical trial evaluation of interventions early in the Alzheimer’s disease course to complement existing imaging and clinical metrics. To determine whether: (i) normalized regional sodium-MRI values (Na-SI) are better predictors of neurocognitive status than volumetry (ii) cerebral amyloid PET status improves modelling. Nondemented older adult (>60 years) volunteers of known Alzheimer's Disease Assessment Scale (ADAS-Cog11), Mini-Mental State Examination (MMSE) and Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neurocognitive test scores, ApolipoproteinE (APOE) e4 +/− cerebral amyloid PET status were prospectively recruited for 3T sodium-MRI brain scans. Left and right hippocampal, entorhinal and precuneus volumes and Na-SI (using the proportional intensity scaling normalization method with field inhomogeneity and partial volume corrections) were obtained after segmentation and co-registration of 3D-T1-weighted proton images. Descriptive statistics, correlation and best-subset regression analyses were performed. In our 76 nondemented participants (mean(standard deviation) age 75(5) years; woman 47(62%); cognitively unimpaired 54/76(71%), mildly cognitively impaired 22/76(29%)), left hippocampal Na-SI, not volume, was preferentially in the best models for predicting MMSE (Odds Ratio (OR) = 0.19(Confidence Interval (CI) = 0.07,0.53), P-value = 0.001) and ADAS-Cog11 (Beta(B) = 1.2(CI = 0.28,2.1), P-value = 0.01) scores. In the entorhinal analysis, right entorhinal Na-SI, not volume, was preferentially selected in the best model for predicting ADAS-Cog11 (B = 0.94(CI = 0.11,1.8), P-value = 0.03). While right entorhinal Na-SI and volume were both selected for MMSE modelling (Na-SI OR = 0.23(CI = 0.09,0.6), P-value = 0.003; volume OR = 2.6(CI = 1.0,6.6), P-value = 0.04), independently, Na-SI explained more of the variance (Na-SI R2 = 10.3; volume R2 = 7.5). No imaging variable was selected in the best CERAD models. Adding cerebral amyloid status improved model fit (Akaike Information Criterion increased 2.0 for all models, P-value < 0.001–0.045). Regional Na-SI were more predictive of MMSE and ADAS-Cog11 scores in our nondemented older adult cohort than volume, hippocampal more robust than entorhinal region of interest. Positive amyloid status slightly further improved model fit.

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Elevated serum sodium is linked to increased amyloid‐dependent tau pathology, neurodegeneration, and cognitive impairment in Alzheimer's disease

Chen,

Wang,

Liu

et al. 2024

Journal of Neurochemistry

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Vascular dysfunction is implicated in the pathophysiology of Alzheimer's disease (AD). While sodium is essential for maintaining vascular function, its role in AD pathology remains unclear. We included 353 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI), assessing serum sodium levels, cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers, magnetic resonance imaging (MRI), and cognitive function. An independent sample (N = 471) with available CSF sodium‐related proteins and AD biomarkers was also included. Associations between serum sodium levels and AD pathology, neurodegeneration, and cognition were evaluated using linear regression models. Spearman's correlation analyses assessed the relationships between CSF sodium‐related proteins and AD biomarkers. Higher serum sodium levels were associated with increased AD pathology, reduced hippocampal volume, and greater cognitive decline (all p < 0.05). The relationship between serum sodium and amyloid PET was evident in several AD‐susceptible brain regions, including the neocortex and limbic system. Individuals with high serum sodium exhibited higher tau pathology, lower hippocampal volume, and more severe cognitive decline per unit increase in amyloid PET compared to those with low serum sodium (all p < 0.05). Among the 14 CSF sodium‐related proteins, which were inter‐correlated, six were significantly correlated with CSF AD pathology and amyloid PET, while two were correlated with hippocampal volume and cognitive function, with sodium channel subunit beta‐2 (SCN2B) and sodium channel subunit beta‐3 (SCN3B) showing the strongest correlations. These findings underscore the crucial role of serum sodium in AD progression, highlighting a potential network of sodium dysregulation involved in AD pathology. Targeting sodium may offer a novel therapeutic approach to slowing AD progression, particularly by impeding the progression of amyloid‐related downstream events.image

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3T sodium MR imaging in Alzheimer’s disease shows stage-dependent sodium increase influenced by age and local brain volume

Cited by 3 publications

References 66 publications

Resolution enhancement, noise suppression, and joint T2* decay estimation in dual‐echo sodium‐23 MR imaging using anatomically guided reconstruction

Resolution enhancement, noise suppression, and joint T2* decay estimation in dual‐echo sodium‐23 MR imaging using anatomically guided reconstruction

3T sodium-MRI as predictor of neurocognition in nondemented older adults: a cross sectional study

Elevated serum sodium is linked to increased amyloid‐dependent tau pathology, neurodegeneration, and cognitive impairment in Alzheimer's disease

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