3β-Aminospirosolane Steroidal Alkaloids from Solanum triste

Maxwell, Anderson; Seepersaud, Mohindra; Pingal, Ramish; Mootoo, David R.; Reynolds, William F.

doi:10.1021/np50118a027

Cited by 28 publications

(25 citation statements)

References 12 publications

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“…Two rare C-3 amino steroidal alkaloids, 188 and 189 , were isolated from aerial parts of S. triste [362, 471]. Three C-27 steroidal glycoalkaloids, spiralosides A ( 194 ), B ( 193 ), C ( 192 ), were obtained from the fruits of S. spirale [474].…”

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

111

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Over the past 30 years, the genus Solanum has received considerable attention in chemical and biological studies. Solanum is the largest genus in the family Solanaceae, comprising of about 2000 species distributed in the subtropical and tropical regions of Africa, Australia, and parts of Asia, e.g., China, India and Japan. Many of them are economically significant species. Previous phytochemical investigations on Solanum species led to the identification of steroidal saponins, steroidal alkaloids, terpenes, flavonoids, lignans, sterols, phenolic comopunds, coumarins, amongst other compounds. Many species belonging to this genus present huge range of pharmacological activities such as cytotoxicity to different tumors as breast cancer (4T1 and EMT), colorectal cancer (HCT116, HT29, and SW480), and prostate cancer (DU145) cell lines. The biological activities have been attributed to a number of steroidal saponins, steroidal alkaloids and phenols. This review features 65 phytochemically studied species of Solanum between 1990 and 2018, fetched from SciFinder, Pubmed, ScienceDirect, Wikipedia and Baidu, using “Solanum” and the species’ names as search terms (“all fields”).

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Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

111

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“…Percentage Alkaloids were determined by the methods of AOAC and Maxwell [29,30]. Percentage Flavonoids, Saponins and Tannins were also determined by the procedures according to Cloupai-Abyazini, Peng and Kobayashi [31], while percentage Phenols were estimated by the method of Harborn [32].…”

Section: Determination Of Percentage Bioactive Compoundsmentioning

confidence: 99%

Nutritional and Bioactive Compounds Evaluation of Pleurotus pulmonarius (Freis) Quell Fruit bodies Grown on Different Wood Logs in Abia State, Nigeria

Mc¹,

Ur²,

Ic³

et al. 2017

J Pet Environ Biotechnol

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This study was conducted to determine the nutritional and bioactive compounds composition of Pleurotus pulmonarius fruit bodies cultivated on tree logs of Dacryodes edulis, Mangifera indica and Treculia africana. Pure mycelium culture of P. pulmonarius was aseptically bulked in sorghum grains. Logs were cut into average length of 18 cm with inoculation holes of 3 cm × 15 mm diameter; using High Speed Drill (HSD) of 5 drill bit and allowed to decompose for 8months. During mushroom cultivation, logs were soaked in tap water for 24 hrs and pasteurized at 80°C in an improvised metallic drum (IMD) for 1hour; using cooking gas as heat source and allowed to cool overnight. 10 g of grain based spawn was inserted into 2/3 of each hole by way of inoculation and sealed with sterile polybag for mycelium incubation. Polybags were cut open after spawn run following primordial initiation. Fruit bodies were harvested at maturity, sun-dried ground and packed in airtight container prior to further analysis. Data were analyzed using Analysis of Variance (ANOVA) and mean separation by Duncan Multiple Range Test (DMRT) while levels of significance were determined at 5%. Results indicate that P. pulmonarius fruit bodies harvested from various tree logs were significantly different p<0.05 in their nutritional and bioactive compounds composition. Fruit body samples were rich in protein, carbohydrates, Na, K, and Ca. It was also observed that fruit bodies contained significant amount of Alkaloids, Tannins and Saponins; and could be useful in drug synthesis. Therefore, adopting this technique in oyster mushroom cultivation would lead to more jobs creation and food security; but this must be done with careful regulations to avoid indiscriminate felling of trees.

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“…This may be due to the high level of alkaloids and flavonoids found in O. gratissimum. Alkaloids are known as the starting material in the manufacture of steroidal drugs [51]. Flavonoids are functional as disease-resistance agents; O. gratissimum also contains tannins that inhibit oxidation [52].…”

Section: Discussionmentioning

confidence: 99%

Preclinical immunohistochemical biomarkers for testicular changes in hyperlipidemic rats and the role of Ocimum gratissimum

Gazia¹

2013

The Egyptian Journal of Histology

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BackgroundHigh plasma levels of cholesterol or triglycerides were accompanied by testicular dysfunction, besides being a high risk factor for coronary and cerebrovascular diseases. PurposeThe aim of the study was to investigate the histological effect of Ocimum gratissimum on the testes of rats with tyloxapol-induced hyperlipidemia as well as investigate its effect on androgen receptor (AR) and proliferating cell nuclear antigen (PCNA) distribution as a molecular biomarker for spermatogenesis. Materials and methodsTwenty-four adult male albino rats were used and divided into four equal groups: the control group (group I); the group treated with crude aqueous extract of O. gratissimum (group II); the tyloxapol-injected group (group III); and the group injected with tyloxapol followed by treatment with O. gratissimum (group IV). The rats were anesthetized at the time of sacrifice; thereafter, blood samples were collected to estimate the lipid profile levels, and the testis specimens were examined histologically and immunohistochemically for AR and PCNA. ResultsThe present results showed a significant increase in the levels of total cholesterol, triglycerides, and low-density lipoprotein and a decrease in the levels of high-density lipoprotein in the tyloxapol-injected group (hyperlipidemic rats) with histological changes in the form of loss of normal distribution of spermatogenic cells, vacuolation, diminution of germinal epithelium, and sloughing of germ cells into the tubular lumen with acidophilic material in the interstitial tissues when compared with the control group. Immunohistochemical study showed a significant decrease in the intensity of AR immunostaining in Sertoli, Leydig, and peritubular myoid cells and in the number of PCNA immunopositive germ cells; the index PCNA values were also significantly decreased in tyloxapol-injected rats in comparison with controls. O. gratissimum administration after tyloxapol injection induced a significant reduction in lipid profile with marked improvement in testicular histological changes as well as increase in the number of AR and PCNA immunopositive cells. ConclusionThis study revealed that AR and PCNA indexing can be used as a preclinical biomarker for testicular changes in hyperlipidemic states. The extract of O. gratissimum leaves provides effective hypolipidemic activity and exerts significant improvement in combating the harmful effects of hyperlipidemia on the rat testes.

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3β-Aminospirosolane Steroidal Alkaloids from Solanum triste

Cited by 28 publications

References 12 publications

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Nutritional and Bioactive Compounds Evaluation of Pleurotus pulmonarius (Freis) Quell Fruit bodies Grown on Different Wood Logs in Abia State, Nigeria

Preclinical immunohistochemical biomarkers for testicular changes in hyperlipidemic rats and the role of Ocimum gratissimum

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