4.0 T Water Proton T₁ Relaxation Times in Normal Human Brain and During Acute Ethanol Intoxication

Abstract

This reasonably sensitive measurement does not support the view that tissue water content or water macromolecule interactions are significantly altered in the brain during acute alcohol intoxication in otherwise healthy subjects.

On the Accuracy of In Vivo Ethanol and Acetaldehyde Monitoring, a Key Tile in the Puzzle of Acetaldehyde as a Neuroactive Agent

“…In vivo MRS can be performed with common clinical magnetic resonance imaging equipments and since EtOH methyl protons can be detected (Sammi et al, 2000), MRS has been largely used to measure in vivo brain EtOH levels in both humans and laboratory animals (Hanstock et al, 1990; Kaufman et al, 1994; Rooney et al, 2000; Zahr et al, 2010). However, magnetic transfer evidences have clearly shown the in vivo presence of a free, observable EtOH pool and a membrane-associated EtOH pool that escapes direct detection (Fein and Meyerhoff, 2000; Nagel and Kroenke, 2008).…”