4′-(1H-Imidazol-2-yl)-3′-[(1H-indol-3-yl)carbonyl]-1′-methyl-2-oxospiro[indoline-3,2′-pyrrolidine]-3′-carbonitrile 0.15-hydrate

Abstract

In the title compound, C25H20N6O2·0.15H2O, the dihedral angles between the least-squares planes of the indole and pyrrolidine rings and between the oxindole and imidazole rings are 77.66 (7) and 45.31 (7)°, respectively. The pyrrolidine ring and the fused five-membered pyrrolidine ring of the oxindole moiety exhibit twisted conformations. The amide N atom is involved in both intra- and inter­molecular hydrogen bonding, having a bifurcated character. The mol­ecular structure is characterized by an intra­molecular N—H⋯O hydrogen bond, which generates an S(7) ring motif while an inter­molecular N—H⋯O hydrogen bond links the organic and solvent water mol­ecules. In the crystal, N—H⋯N hydrogen bonds generate a zigzag chain running parallel to c-axis direction. The H atoms of the solvent water mol­ecule were not located.