4:12 PM Abstract No. 209 Neovascularization in knee osteoarthritis: a new mouse model using micro computed tomography to delineate pathological vascular remodeling

Abstract

additional embolization procedure. No significant demographic differences were identified between the embolization and conservative management groups. Multivariable logistic regression identified active extravasation on computed tomography (CT) scan (p ¼ 0.01), hematoma volume greater than 1300 mL 3 (p ¼ 0.01), transfusion of 3 or more units of packed red blood cells (pRBC) (p ¼ 0.04), and maximum rate of hemoglobin drop greater than 0.25 g/dL per hour (p ¼ 0.01) as predictors of need for embolization. Using these parameters, a scoring system was created to predict failure of conservative management. Application of the scoring system to patients in the study population yielded a sensitivity of 100% and specificity of 98% in determining need for embolization. Conclusions: A considerable number of patients with spontaneous RSH included in this analysis failed conservative management. Using common clinical and imaging parameters, a scoring system was established that successfully correlated with patients with RSH who were likely to escalate to embolization. This scoring system may be useful as a tool to predict need for embolization in future patients, though further prospective study is required.

Emerging Targets for the Treatment of Osteoarthritis: New Investigational Methods to Identify Neo-Vessels as Possible Targets for Embolization

“…Chronic inflammation alters chondrocyte function, shifting normal cell signaling to pro-inflammatory cytokines, which in turn promotes angiogenesis [ 3 ]. Multiple small animal models have demonstrated that the degree of angiogenesis correlates with more severe OA [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. These new vessels may in turn function as a conduit for continued joint inflammation and new neuronal migration [ 2 ].…”