4.23 Polymers in Oral Drug Delivery

Mastropietro, David J; Park, K.; Omidian, Hossein

doi:10.1016/b978-0-12-803581-8.09291-2

Cited by 25 publications

(28 citation statements)

References 63 publications

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“…1 ), promoting unfolding and enhancing viscosity by electrostatic repulsion. 18–22 This work reveals 1 H MAS NMR to provide suitable sensitivity and resolution to detect structural changes induced in organic polymers during their hydration. Magnetohydrodynamic mixing was shown to not only induce less structural damage during the mixing process, as compared to high shear mixing, magneto-hydrodynamic mixing also generates long-lived charge stabilization on the polymer, giving rise to enhanced properties of the hydrated carbomer dispersion.…”

mentioning

confidence: 97%

Dispersing carbomers, mixing technology matters!

Houlleberghs

Verheyden

Voorspoels³

et al. 2022

RSC Adv.

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mentioning

confidence: 97%

Dispersing carbomers, mixing technology matters!

Houlleberghs

Verheyden

Voorspoels³

et al. 2022

RSC Adv.

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“…In vitro tests showed good biocompatibility on normal L929 murine fibroblast cells and anti-cancer properties against A431 human skin carcinoma cell lines [ 139 ]. Furthermore, Jangde et al [ 140 ] incorporated quercetin into a multiphase hydrogel consisting of Carbopol ® (the trade name for carbomers, high molecular weight cross-linked poly(acrylic acid) polymers) and varying gelatin ratio. The most suitable hydrogel was obtained at a ratio of gelatin to Carbopol ® of 6 to 4, which exhibited accelerated wound healing and reduced wound closure time albino rat models [ 141 ].…”

Section: Wound Dressings In Skin Cancermentioning

confidence: 99%

Regenerative Wound Dressings for Skin Cancer

Pavel

Chircov

Rădulescu

et al. 2020

Cancers

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Skin cancer is considered the most prevalent cancer type globally, with a continuously increasing prevalence and mortality growth rate. Additionally, the high risk of recurrence makes skin cancer treatment among the most expensive of all cancers, with average costs estimated to double within 5 years. Although tumor excision is the most effective approach among the available strategies, surgical interventions could be disfiguring, requiring additional skin grafts for covering the defects. In this context, post-surgery management should involve the application of wound dressings for promoting skin regeneration and preventing tumor recurrence and microbial infections, which still represents a considerable clinical challenge. Therefore, this paper aims to provide an up-to-date overview regarding the current status of regenerative wound dressings for skin cancer therapy. Specifically, the recent discoveries in natural biocompounds as anti-cancer agents for skin cancer treatment and the most intensively studied biomaterials for bioactive wound dressing development will be described.

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“…PMAA was the first polymethacrylate used in oral dosage form for drug delivery [ 24 ]. Two copolymers of PMAA have been applied with gastrointestinal (GI) tract targeting for drug delivery: (i) poly(methacrylic acid-co-ethyl acrylate) dissolved in duodenum at pH > 5.5, and (ii) poly(methacrylic acid-co-methyl methacrylate) dissolved in jejunum at pH > 6.0 or in colon at pH > 7.0 [ 25 ]. These copolymers are supplied under the trade name Eudragit for pharmaceutical applications.…”

Section: Introductionmentioning

confidence: 99%

“…The synthesis was carried out by IEP, under free-radical polymerization using water as continuous media, through a “grafting from” approach. In contrast to previously published in other works for drug delivery systems prepared with PMAA [ 24 , 25 ], in this work, BA co-monomer and functionalized CNTs were used in the preparation. It is expected that the last two components of the studied PNs increase their capacity to deliver drugs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Poly(methacrylic acid-co-butyl acrylate) Grafted onto Functionalized Carbon Nanotube Nanocomposites for Drug Delivery

et al. 2021

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Design of a smart drug delivery system is a topic of current interest. Under this perspective, polymer nanocomposites (PNs) of butyl acrylate (BA), methacrylic acid (MAA), and functionalized carbon nanotubes (CNTsf) were synthesized by in situ emulsion polymerization (IEP). Carbon nanotubes were synthesized by chemical vapor deposition (CVD) and purified with steam. Purified CNTs were analyzed by FE-SEM and HR-TEM. CNTsf contain acyl chloride groups attached to their surface. Purified and functionalized CNTs were studied by FT-IR and Raman spectroscopies. The synthesized nanocomposites were studied by XPS, 13C-NMR, and DSC. Anhydride groups link CNTsf to MAA–BA polymeric chains. The potentiality of the prepared nanocomposites, and of their pure polymer matrices to deliver hydrocortisone, was evaluated in vitro by UV–VIS spectroscopy. The relationship between the chemical structure of the synthesized nanocomposites, or their pure polymeric matrices, and their ability to release hydrocortisone was studied by FT-IR spectroscopy. The hydrocortisone release profile of some of the studied nanocomposites is driven by a change in the inter-associated to self-associated hydrogen bonds balance. The CNTsf used to prepare the studied nanocomposites act as hydrocortisone reservoirs.

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4.23 Polymers in Oral Drug Delivery

Cited by 25 publications

References 63 publications

Dispersing carbomers, mixing technology matters!

Dispersing carbomers, mixing technology matters!

Regenerative Wound Dressings for Skin Cancer

Synthesis of Poly(methacrylic acid-co-butyl acrylate) Grafted onto Functionalized Carbon Nanotube Nanocomposites for Drug Delivery

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