4,4′‐Diaponeurosporene‐Producing <i>Bacillus subtilis</i> Promotes the Development of the Mucosal Immune System of the Piglet Gut

Jing, Yuchao; Liu, Haofei; Xu, Wenwen; Yang, Qian

doi:10.1002/ar.24102

Cited by 14 publications

(8 citation statements)

References 56 publications

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“…Oral administration with toxins, bacteria or viruses can effectively induce immune responses in young pig's PPs, characterized by dendritic cell (DC) and T-cell activation, upregulated expression levels of cytokines and sIgA antibody (5)(6)(7)(8), indicating that IPP may play a vital role in intestinal mucosal immune responses against pathogens in pigs. However, the mechanisms in regulating IgA production in the IPP of pigs have not been described in detail.…”

Section: Introductionmentioning

confidence: 99%

Interleukin (IL)-21 Promotes the Differentiation of IgA-Producing Plasma Cells in Porcine Peyer's Patches via the JAK-STAT Signaling Pathway

Wang

Chen

et al. 2020

Front. Immunol.

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Secretory IgA is critical to prevent the invasion of pathogens via mucosa. However, the key factors and the mechanisms of IgA generation in the porcine gut are not well-understood. In this study, a panel of factors, including BAFF, APRIL, CD40L, TGF-β1, IL-6, IL-10, IL-17A, and IL-21, were employed to stimulate IgM + B lymphocytes from porcine ileum Peyer's patches. The results showed that IL-21 significantly upregulated IgA production of B cells and facilitated cell proliferation and differentiation of antibody-secreting cells. In addition, three transcripts in porcine IgA class switch recombination (CSR), germ-line transcript α, post-switch transcript α, and circle transcript α, were first amplified by (nest-)PCR and sequenced. All these key indicators of IgA CSR were upregulated by IL-21 treatment. Furthermore, we found that IL-21 predominantly activated JAK1, STAT1, and STAT3 proteins and confirmed that the JAK-STAT signaling pathway was involved in porcine IgA CSR. Thus, IL-21 plays an important role in the proliferation and differentiation of IgA-secreting cells in porcine Peyer's patches through the JAK-STAT signaling pathway. These findings provide insights into the mucosal vaccine design by regulation of IL-21 for the prevention and control of enteric pathogens in the pig industry.

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Section: Introductionmentioning

confidence: 99%

Interleukin (IL)-21 Promotes the Differentiation of IgA-Producing Plasma Cells in Porcine Peyer's Patches via the JAK-STAT Signaling Pathway

Wang

Chen

et al. 2020

Front. Immunol.

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“…4,4′-Diaponeurosporene (C 30 H 42 ; also known as 7,8-dihydro-4,4′-diapo-ψ,ψ-carotene and all-trans -4,4′-diaponeurosporene) has been isolated from S. aureus , Heliobacteria, and L. plantarum subsp. plantarum , among others [ 17 , 22 , 28 , 29 , 30 ]. Research on the deep-yellow pigment revealed its potential against Salmonella typhimurium in a mouse model.…”

Section: Microbial C 30 Carotenoids and Their Deri...mentioning

confidence: 99%

Antioxidant Potential and Capacity of Microorganism-Sourced C30 Carotenoids—A Review

2022

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Carotenoids are lipophilic tetraterpenoid pigments produced by plants, algae, arthropods, and certain bacteria and fungi. These biologically active compounds are used in the food, feed, and nutraceutical industries for their coloring and the physiological benefits imparted by their antioxidant properties. The current global carotenoid market is dominated by synthetic carotenoids; however, the rising consumer demand for natural products has led to increasing research and development in the mass production of carotenoids from alternative natural sources, including microbial synthesis and plant extraction, which holds a significant market share. To date, microbial research has focused on C40 carotenoids, but studies have shown that C30 carotenoids contain similar—and in some microbial strains, greater—antioxidant activity in both the physical and chemical quenching of reactive oxygen species. The discovery of carotenoid biosynthetic pathways in different microorganisms and advances in metabolic engineering are driving the discovery of novel C30 carotenoid compounds. This review highlights the C30 carotenoids from microbial sources, showcasing their antioxidant properties and the technologies emerging for their enhanced production. Industrial applications and tactics, as well as biotechnological strategies for their optimized synthesis, are also discussed.

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“…Gut microbiota has a crucial role in intestinal absorption and digestion, intestinal immune regulation, and intestinal health of weaned piglets ( 38 ). Gut bacterial dysbiosis usually results in post-weaning diarrhea ( 18 , 90 , 91 ), which lead to intestinal barrier injury, reduce the size of the intestinal villi, result in atrophy of the enterocytes and lower digestive capacity, and decrease the weight gain of the piglet ( 82 , 92 ). Intestinal tract is an important target of nutritional regulation.…”

Section: Pharmacological Applications Of Phytochemicals In Pig Productionmentioning

confidence: 99%

Pharmacological Applications and Action Mechanisms of Phytochemicals as Alternatives to Antibiotics in Pig Production

Sun

Zhao

et al. 2021

Front. Immunol.

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Antibiotics are widely used for infectious diseases and feed additives for animal health and growth. Antibiotic resistant caused by overuse of antibiotics poses a global health threat. It is urgent to choose safe and environment-friendly alternatives to antibiotics to promote the ecological sustainable development of the pig industry. Phytochemicals are characterized by little residue, no resistance, and minimal side effects and have been reported to improve animal health and growth performance in pigs, which may become a promising additive in pig production. This paper summarizes the biological functions of recent studies of phytochemicals on growth performance, metabolism, antioxidative capacity, gut microbiota, intestinal mucosa barrier, antiviral, antimicrobial, immunomodulatory, detoxification of mycotoxins, as well as their action mechanisms in pig production. The review may provide the theoretical basis for the application of phytochemicals functioning as alternative antibiotic additives in the pig industry.

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4,4′‐Diaponeurosporene‐Producing Bacillus subtilis Promotes the Development of the Mucosal Immune System of the Piglet Gut

Cited by 14 publications

References 56 publications

Interleukin (IL)-21 Promotes the Differentiation of IgA-Producing Plasma Cells in Porcine Peyer's Patches via the JAK-STAT Signaling Pathway

Interleukin (IL)-21 Promotes the Differentiation of IgA-Producing Plasma Cells in Porcine Peyer's Patches via the JAK-STAT Signaling Pathway

Antioxidant Potential and Capacity of Microorganism-Sourced C30 Carotenoids—A Review

Pharmacological Applications and Action Mechanisms of Phytochemicals as Alternatives to Antibiotics in Pig Production

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