4.4 Vitamins and Minerals Treat Antenatal Depression and Improve Birth and Infant Development: Results of the Double-Blind NutriMum RCT

Rucklidge, Julia J.; Bradley, Hayley A.; Campbell, Siobhán; Heaton, Jessica L.; Mulder, Roger; Henderson, Jacki; Dixon, Lesley; Moltchanova, Elena

doi:10.1016/j.jaac.2022.07.579

Cited by 4 publications

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“…Improvements in mood were observed in the full cohort over the 12-week study period; these have been reported elsewhere [ 46 ]. There was also a modest inverse association between changes in vitamin C status and changes in anxiety, as assessed by the CGI-S anxiety subscale, over the 12-week study period.…”

Section: Discussionsupporting

confidence: 73%

Inflammation and Vitamin C in Women with Prenatal Depression and Anxiety: Effect of Multinutrient Supplementation

et al. 2023

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Elevated inflammation has been associated with adverse mood states, such as depression and anxiety, and antioxidant nutrients, such as vitamin C, have been associated with decreased inflammation and improved mood. In the current study comprising a cohort of pregnant women with depression and anxiety, we hypothesised that elevated inflammation would be associated with adverse mood states and inversely associated with vitamin C status and that multinutrient supplementation would optimise vitamin concentrations and attenuate inflammation. Sixty-one participants from the NUTRIMUM trial had blood samples collected between 12 and 24 weeks gestation (baseline) and following 12 weeks of daily supplementation with a multinutrient formula containing 600 mg of vitamin C or active placebo. The samples were analysed for inflammatory biomarkers (C-reactive protein (CRP) and cytokines) and vitamin C content and were related to scales of depression and anxiety. Positive correlations were observed between interleukin-6 (IL-6) and all of the mood scales administered (p < 0.05), including the Edinburgh Postnatal Depression Scale, the Clinical Global Impressions—Severity Scale, the Montgomery and Åsberg Depression Rating Scale, the Depression Anxiety Stress Scale 21, and the Generalized Anxiety Disorder-7 (GAD-7). CRP correlated weakly with GAD-7 (p = 0.05). There was an inverse correlation between CRP and the vitamin C status of the cohort (p = 0.045), although there was no association of the latter with the mood scales (p > 0.05). Supplementation with the multinutrient formula resulted in a significant increase in the vitamin C status of the cohort (p = 0.007) but did not affect the inflammatory biomarker concentrations (p > 0.05). In conclusion, greater systemic inflammation was associated with worse mood states; however, 12-week multinutrient supplementation did not alter inflammatory biomarker concentrations. Nevertheless, the vitamin C status of the cohort was improved with supplementation, which may aid pregnancy and infant outcomes.

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Section: Discussionsupporting

confidence: 73%

Inflammation and Vitamin C in Women with Prenatal Depression and Anxiety: Effect of Multinutrient Supplementation

et al. 2023

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“…Given the role that temperament plays in the dyadic nature of the mother-infant relationship, every effort should be made to protect vulnerable infants from challenges that could arise related to social and emotional development. BSM appears to be a promising option given its success in treating antenatal depression (71), and the current study provides reassurance in its safety with relation to infant temperament, suggesting that by mitigating the risks associated with antenatal depression, we can set these potentially at-risk infants on a more positive developmental trajectory.…”

Section: Discussionmentioning

confidence: 73%

“…Managing maternal mental health has become a central component in antenatal care, and a recent RCT showed that introducing a BSM regimen for pregnant women with antenatal depression could result in meaningful improvements in their mental health ( 71 ) in addition to positively influencing infant birth and neurobehavioral outcomes in the first weeks of life ( 71 , 86 ). The current study investigated whether this BSM exposure had any impact on the temperament of these women’s infants across their first year of life.…”

Section: Discussionmentioning

confidence: 99%

“…A portion of the current sample included 46 infants whose mothers had previously participated in a randomized, placebo-controlled trial (RCT) conducted between 2017 and 2021 (NUTRIMUM Trial: ( 70 , 71 )). For the RCT, participants between 12 and 24 weeks’ gestation identified with depressive symptomology during pregnancy (Edinburgh Postnatal Depression Scale: EPDS ≥13), and not taking any psychiatric medication, were randomized to receive daily BSM or a placebo for 12 weeks during their pregnancy The BSM formula used in the NUTRIMUM study, Daily Essential Nutrients (DEN), contains 36 essential vitamins, minerals, amino acids and antioxidants, and this combination of nutrients has been explored as a treatment for other psychiatric illnesses in non-pregnant populations ( 65 ).…”

Section: Methodsmentioning

confidence: 99%

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Exploring the impact of antenatal micronutrients used as a treatment for maternal depression on infant temperament in the first year of life

Campbell,

Dys,

Henderson

et al. 2024

Front. Nutr.

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Antenatal depression and maternal nutrition can influence infant temperament. Although broad-spectrum-micronutrients (BSM: vitamins and minerals) given above Recommended Dietary Allowances during pregnancy can mitigate symptoms of antenatal depression, their associated effects on infant temperament are unknown. One hundred and fourteen New Zealand mother-infant dyads (45 infants exposed to BSM during pregnancy (range of exposure during pregnancy: 12–182 days) to treat antenatal depressive symptoms (measured by Edinburgh Postnatal Depression Scale) and 69 non-exposed infants) were followed antenatally and for 12 months postpartum to determine the influence of in utero BSM exposure on infant temperament. The Infant Behavior Questionnaire–Revised: Very Short-Form assessed temperament at 4 (T1), 6 (T2) and 12 (T3) months postpartum via online questionnaire. Latent growth curve modeling showed BSM exposure, antenatal depression and infant sex did not statistically significantly predict initial levels or longitudinal changes in orienting/regulatory capacity (ORC), positive affectivity/surgency (PAS) or negative affectivity (NEG). Higher gestational age was positively associated with initial PAS, and smaller increases between T1 and T3. Breastfeeding occurrence was positively associated with initial NEG. Although not significant, BSM exposure exerted small, positive effects on initial NEG (β = −0.116) and longitudinal changes in ORC (β = 0.266) and NEG (β = −0.235). While BSM exposure did not significantly predict infant temperament, it may mitigate risks associated with antenatal depression. BSM-exposed infants displayed temperamental characteristics on par with typical pregnancies, supporting the safety of BSM treatment for antenatal depression.

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Dietary interventions for perinatal depression and anxiety: a systematic review and meta-analysis of randomized controlled trials

Tsai

Shah

Tahir

et al. 2023

The American Journal of Clinical Nutrition

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4.4 Vitamins and Minerals Treat Antenatal Depression and Improve Birth and Infant Development: Results of the Double-Blind NutriMum RCT

Cited by 4 publications

References 0 publications

Inflammation and Vitamin C in Women with Prenatal Depression and Anxiety: Effect of Multinutrient Supplementation

Inflammation and Vitamin C in Women with Prenatal Depression and Anxiety: Effect of Multinutrient Supplementation

Exploring the impact of antenatal micronutrients used as a treatment for maternal depression on infant temperament in the first year of life

Dietary interventions for perinatal depression and anxiety: a systematic review and meta-analysis of randomized controlled trials

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