4,7-Dihydro-, 4,5,6,7-tetrahydro-, and octahydroisoindoles (and methanoisoindoles). (Review)

Abstract

Data on the synthesis and biological characteristics of hydrogenated isoindoles and methanoisoindoles are reviewed and analyzed.

A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas

“…Several traditional methods are available for the synthesis of isoindolinones [ 16 – 25 ], based on the use of Grignard reagents [ 26 ], Diels–Alder reactions [ 27 ], Wittig reagents [ 28 ], reduction processes [ 29 – 30 ], rearrangement processes [ 31 ] and photochemical reactions [ 32 – 33 ]. However, such methods generally require multiple reaction steps and are unsatisfactory both in yield and generality.…”