4‐Amino‐3‐acetylquinoline‐induced apoptosis of murine L1210 leukemia cells involves ROS‐mitochondrial‐mediated death signaling and activation of p38 MAPK

Jantová, Soňa; Repicky, A; Letašiová, Silvia; Čipák, Luboš

doi:10.1002/cbf.1485

Cited by 12 publications

(5 citation statements)

References 40 publications

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“…Numerous researchers have shown that ROS relate to apoptosis that is processed through the mitochondrial pathway, which depends on the activation of p38 (Figure 2) [40][41][42][43][44] . Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogenactivated protein 3-kinase that activates both JNK and p38 MAPK, which may also be triggered by ROS [45][46][47][48][49] .…”

Section: Ros Involve Apoptosis That Relates To the P38 Pathwaymentioning

confidence: 99%

Reactive oxygen species: A double-edged sword in oncogenesis

Pan¹,

Hong²,

Ren³

2009

WJG

206

133

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Reactive oxygen species (ROS) are molecules or ions formed by the incomplete one-electron reduction of oxygen. Of interest, it seems that ROS manifest dual roles, cancer promoting or cancer suppressing, in tumorigenesis. ROS participate simultaneously in two signaling pathways that have inverse functions in tumorigenesis, Ras-Raf-MEK1/2-ERK1/2 signaling and the p38 mitogen-activated protein kinases (MAPK) pathway. It is well known that Ras-Raf-MEK1/2-ERK1/2 signaling is related to oncogenesis, while the p38 MAPK pathway contributes to cancer suppression, which involves oncogene-induced senescence, inflammationinduced cellular senescence, replicative senescence, contact inhibition and DNA-damage responses. Thus, ROS may not be an absolute carcinogenic factor or cancer suppressor. The purpose of the present review is to discuss the dual roles of ROS in the pathogenesis of cancer, and the signaling pathway mediating their role in tumorigenesis.

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Section: Ros Involve Apoptosis That Relates To the P38 Pathwaymentioning

confidence: 99%

Reactive oxygen species: A double-edged sword in oncogenesis

Pan¹,

Hong²,

Ren³

2009

WJG

206

133

View full text Add to dashboard Cite

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“…Several researchers have shown that ROS related apoptosis is processed by the mitochondrial pathway, through the activation of p38 [ 73 , 74 , 75 ]. It has been demonstrated that ROS-dependent activation of MAPKs is crucial for mitochondria-mediated apoptosis [ 76 ].…”

Section: Role Of Ros and Hne In The Hallmarks Of Cancermentioning

confidence: 99%

The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer

Pizzimenti

Toaldo

Pettazzoni

et al. 2010

Cancers

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Reacytive Oxygen Species (ROS) have long been considered to be involved in the initiation, progression and metastasis of cancer. However, accumulating evidence points to the benefical role of ROS. Moreover, ROS production, leading to apoptosis, is the mechanism by which many chemotherapeutic agents can act. Beside direct actions, ROS elicit lipid peroxidation, leading to the production of 4-hydroxynoneal (HNE). Interestingly, HNE also seems to have a dual behaviour with respect to cancer. In this review we present recent literature data which outline the "two-faced" character of oxidative stress and lipid peroxidation in carcinogenesis and in the hallmarks of cancer.

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“…Substituted tetrahydroquinolins are important structures present in a wide variety of natural alkaloids and synthetic analogues with high biological activity as potent antitumour agents [ 93 , 94 ]. Amino-quinoline derivatives have been reported to have antiproliferative activity due to their ability to induce mitochondrial dysfunction by increasing ROS levels in the sensitive cervical epithelioid carcinoma cell line HeLaS3 and in the multi-drug resistant human cervical cancer KB-vin cell line [ 95 , 96 ].…”

Section: Chiral Analogues Of Natural Compounds With Stereospecific Cy...mentioning

confidence: 99%

Analogues of Anticancer Natural Products: Chiral Aspects

Valentová

Lintnerová

Miklášova

et al. 2023

IJMS

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Life is chiral, as its constituents consist, to a large degree, of optically active molecules, be they macromolecules (proteins, nucleic acids) or small biomolecules. Hence, these molecules interact disparately with different enantiomers of chiral compounds, creating a preference for a particular enantiomer. This chiral discrimination is of special importance in medicinal chemistry, since many pharmacologically active compounds are used as racemates—equimolar mixtures of two enantiomers. Each of these enantiomers may express different behaviour in terms of pharmacodynamics, pharmacokinetics, and toxicity. The application of only one enantiomer may improve the bioactivity of a drug, as well as reduce the incidence and intensity of adverse effects. This is of special significance regarding the structure of natural products since the great majority of these compounds contain one or several chiral centres. In the present survey, we discuss the impact of chirality on anticancer chemotherapy and highlight the recent developments in this area. Particular attention has been given to synthetic derivatives of drugs of natural origin, as naturally occurring compounds constitute a major pool of new pharmacological leads. Studies have been selected which report the differential activity of the enantiomers or the activities of a single enantiomer and the racemate.

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4‐Amino‐3‐acetylquinoline‐induced apoptosis of murine L1210 leukemia cells involves ROS‐mitochondrial‐mediated death signaling and activation of p38 MAPK

Cited by 12 publications

References 40 publications

Reactive oxygen species: A double-edged sword in oncogenesis

Reactive oxygen species: A double-edged sword in oncogenesis

The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer

Analogues of Anticancer Natural Products: Chiral Aspects

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