“…Compared with compounds 116 (Figure ), the regio‐isomers 117 (IC 50 : 207‐883 nM) showed higher activity against CQR Dd2 strain. Replacement of chloro at pyrimidine by nitrogen‐containing heterocycles ( 118 and 199 ) could increase the activity against CQR Dd2 strain to some extent, but aminoalkanols reduced the activity . Similar SARs were also observed for quinoline‐pyrimidine hybrids 120 to 122 (IC 50 : 120‐440, 140‐240, and 5‐30 nM against CQS 3D7 strain, respectively; 500‐700, 580‐1,170, and 16‐210 nM against CQR Dd2 strain, respectively), quinoline‐pyrimidine hybrids 123 to 130 ( 123 and 124 attaching furan skeleton, IC 50 : 38‐61 and 39‐257 nM against CQS 3D7 and CQR Dd2 strains, respectively; 125 and 126 with piperonyl fragment, IC 50 : 20‐150 and 50‐990 nM against CQS 3D7 and CQR Dd2 strains, respectively; 127 and 128 with pyridine motif, IC 50 : 30‐1193 and 39‐1143 nM against CQS 3D7 and CQR Dd2 strains, respectively; 129 and 130 with thiophene motif, IC 50 : 32.8‐83.7 and 18.9‐409.1 nM against CQS 3D7 and CQR Dd2 strains, respectively) bearing an aromatic ring at the amino near to pyrimidine moiety, and quinoline‐pyrimidine hybrids 131 (IC 50 : 32‐204 and 32‐1018 nM against CQS 3D7 and CQR Dd2 strains, respectively), 132 (IC 50 : 19‐6022 and 46‐9994 nM against CQS 3D7 and CQR Dd2 strains, respectively) incorporating modified anilines at the pyrimidine end.…”