4-Caffeoyl-1,5-quinide in roasted coffee inhibits [3H]naloxone binding and reverses anti-nociceptive effects of morphine in mice

Abstract

These results suggest that the previously reported anti-opioid activity of instant coffee is caused primarily by the presence of 4-CQL, and to lesser extent by other cinnamoyl-1,5-quinides.

Temporal sequence of incident cigarette, coffee, and alcohol use among AA participants

“…Most participants indicated stimulatory benefit as reason for drinking coffee and as perceived effects of consuming coffee, but more than half denied they "needed it" and more than two-thirds denied it gave them a sense of "well-being," arguing against its role as an affect modifier to the extent seen with alcohol and cigarettes. Also, coffee contains other constituents than caffeine that may oppose stimulant effects of caffeine and may modify the psychopharmacological actions of alcohol (15,16). In fact, we have previously reported data from this same sample suggesting coffee drinking may have a protective effect with respect to sobriety of AA participants (14).…”

“…This association is especially important to examine as there is an emerging literature supporting the beneficial effects of coffee consumption on various aspects of mental and physical health, including on complications of chronic alcohol dependence, mediated predominantly by non-caffeine components of this beverage (14)(15)(16). Furthermore, findings of previous research are mixed regarding the role of coffee in alcohol dependence.…”

In vitrostudies on the stability in the proximal gastrointestinal tract and bioaccessibility in Caco-2 cells of chlorogenic acids from spent coffee grounds

“…These two compounds showed a higher losses following incubation with gastrointestinal juices, which could have resulted to the release of the hydroxycinnamate moiety of diCQAs or the cleavage of the intramolecular ester bond of lactones. Previous research has reported positive health effect of lactones (de Paulis et al, 2002(de Paulis et al, , 2004, however these activities might be limited, due to the high losses during the gastrointestinal digestion. Furthermore, the release of CQAs from other structures, including melanoidins, into which they are incorporated during roasting (Bekedam et al, 2008;Perrone et al, 2012), could also be hypothesized.…”

Quantitative analysis of plasma caffeic and ferulic acid equivalents by liquid chromatography tandem mass spectrometry

“…caffeic, ferulic and -coumaric acids) [14], coffee also contains alkaloids (i.e. caffeine and smaller amounts of its precursor, theobromine) [15], cafestol and kahweol [16], some Maillard reaction products (melanoidins) [17][18][19], and quinolactones (with the 3-and 4-isomers being the most abundant) [20,21]. These compounds have also been shown to possess various in vitro or ex vivo biological properties.…”