4-D dielectrophoretic handling of Janus particles in a microfluidic chip

Honegger, T.; Lecarme, O.; Berton, K.; Peyrade, D.

doi:10.1016/j.mee.2009.11.145

Cited by 30 publications

(27 citation statements)

References 8 publications

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“…Positive DEP has been demonstrated for DNA in an optical manipulator using micron-sized localized electrodes created by laser illumination of hydrogenated amorphous silicon. 128 The concept of four-dimensional manipulation using DEP forces has been introduced by Honegger et al 129 using Janus particles. Janus particles are dissymmetric systems with two faces that could present two different physical/chemical properties, offering new possibilities in microfluidic research fields.…”

Section: Technologymentioning

confidence: 99%

“…Janus particles are dissymmetric systems with two faces that could present two different physical/chemical properties, offering new possibilities in microfluidic research fields. In their microfluidic experiment, Honegger et al 129 demonstrated that not only precise 3D localization of these particles is possible, but also that their rotation can be controlled by the gradient of the applied electrical field.…”

Section: Technologymentioning

confidence: 99%

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Review Article—Dielectrophoresis: Status of the theory, technology, and applications

2010

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A review is presented of the present status of the theory, the developed technology and the current applications of dielectrophoresis ͑DEP͒. Over the past 10 years around 2000 publications have addressed these three aspects, and current trends suggest that the theory and technology have matured sufficiently for most effort to now be directed towards applying DEP to unmet needs in such areas as biosensors, cell therapeutics, drug discovery, medical diagnostics, microfluidics, nanoassembly, and particle filtration. The dipole approximation to describe the DEP force acting on a particle subjected to a nonuniform electric field has evolved to include multipole contributions, the perturbing effects arising from interactions with other cells and boundary surfaces, and the influence of electrical double-layer polarizations that must be considered for nanoparticles. Theoretical modelling of the electric field gradients generated by different electrode designs has also reached an advanced state. Advances in the technology include the development of sophisticated electrode designs, along with the introduction of new materials ͑e.g., silicone polymers, dry film resist͒ and methods for fabricating the electrodes and microfluidics of DEP devices ͑photo and electron beam lithography, laser ablation, thin film techniques, CMOS technology͒. Around three-quarters of the 300 or so scientific publications now being published each year on DEP are directed towards practical applications, and this is matched with an increasing number of patent applications. A summary of the US patents granted since January 2005 is given, along with an outline of the small number of perceived industrial applications ͑e.g., mineral separation, micropolishing, manipulation and dispensing of fluid droplets, manipulation and assembly of micro components͒. The technology has also advanced sufficiently for DEP to be used as a tool to manipulate nanoparticles ͑e.g., carbon nanotubes, nano wires, gold and metal oxide nanoparticles͒ for the fabrication of devices and sensors. Most efforts are now being directed towards biomedical applications, such as the spatial manipulation and selective separation/enrichment of target cells or bacteria, high-throughput molecular screening, biosensors, immunoassays, and the artificial engineering of three-dimensional cell constructs. DEP is able to manipulate and sort cells without the need for biochemical labels or other bioengineered tags, and without contact to any surfaces. This opens up potentially important applications of DEP as a tool to address an unmet need in stem cell research and therapy.

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Section: Technologymentioning

confidence: 99%

Section: Technologymentioning

confidence: 99%

Review Article—Dielectrophoresis: Status of the theory, technology, and applications

2010

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“…[20][21][22][23][24][25][26][27] Strategies to create multifunctional micro-particles even with dissymmetric properties, like Janus particles, have been successfully explored. 28,29 Depending on their composition, size, bulk, and surface properties, a large variety of single and collective behaviours have been investigated exploiting different approaches like optical tweezers, colloidal suspensions, and photonic systems. The ability to adjust size, physical properties, and surface functionalities of the micro-particles increases the control parameters driven by external fields (e.g., electric and optical forces and torques) and allows to modulate the inter-particle interactions, 25,26 driving the development of micro devices and sensors, photonics systems and colloidal materials.…”

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confidence: 99%

Self-organized internal architectures of chiral micro-particles

Provenzano

Mazzulla²,

Pagliusi

et al. 2014

APL Materials

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The internal architecture of polymeric self-assembled chiral micro-particles is studied by exploring the effect of the chirality, of the particle sizes, and of the interface/surface properties in the ordering of the helicoidal planes. The experimental investigations, performed by means of different microscopy techniques, show that the polymeric beads, resulting from light induced polymerization of cholesteric liquid crystal droplets, preserve both the spherical shape and the internal self-organized structures. The method used to create the micro-particles with controlled internal chiral architectures presents great flexibility providing several advantages connected to the acquired optical and photonics capabilities and allowing to envisage novel strategies for the development of chiral colloidal systems and materials.

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“…Recently, several attempts to use dielectrophoresis as a novel separation method for nanoparticles with different chemical groups on their various surfaces containing inorganic and polymer materials (Janus particles) were done [27]. "Janus" particles (JP), named after the Roman mythology god (who possessed two faces), are anisotropic dissymmetric particles, with two different physical/ chemical properties, including biphasic material, biocompartmental, dumbbelllike, snowman-like, acorn-like, or half-raspberry-like particles ( Fig.…”

Section: Introduction and Overviewmentioning

confidence: 99%

“…The assembly of Janus metallodielectric particles may find applications in liquid-borne microcircuits and materials with directional electric and heat transfer The metal-coated hemispheres of the particles have a main role in the formation of different structures and in the electrohydrodynamic mobility of the particles once the electric field intensity within the experimental cell becomes strong enough to overcome Brownian motion. The knowledge of Janus particles can be applied to other types of anisotropic particles, which may form different types of novel structures and potentially lead to the fabrication of new materials [27].…”

Section: Introduction and Overviewmentioning

confidence: 99%

Dielectrophoresis Used for Nanoparticle Manipulation in Microfluidic Devices

Lungu

Bunoiu

Neculae

2014

Nanoparticles' Promises and Risks

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Nano-sized particles have received considerable interest in the past two decades. The filtration of nanoparticles is becoming an important issue as they are produced in large numbers from material synthesis or combustion emission, and their effect on human health is relatively high. Dielectrophoresis (DEP), phenomenon that induces spatial movement of particles placed in nonuniform electric field, depending on the dielectric properties of the particles and the surrounding medium, the geometry of the electrodes, and the amplitude and frequency of the applied signal, proved to be the most adequate tool in order to manipulate particles at submicron scale. First, this work presents an overview of the various applications of the dielectrophoresis. Next, the theoretical description of the main forces implied in the spatial control of submicron particles is given. Finally, a mathematical model describing the filtration of nanoparticles suspended in flue gas by a combination of dielectrophoretic and electrohydrodynamic forces, and a set of numerical results obtained by simulations performed in the frame of this model are presented. The dielectrophoretic force and the nanoparticles concentration profile in a DEP-based separation micro system consisting of a micro channel are numerically investigated using the COMSOL Multiphysics finite element code. The performances of the filtration device are analyzed in terms of a specific quantity related to the separation process, called Filtration rate. The simulations provide the optimal set of values for the control parameters of the separation process in order to obtain a desired performance, and represent a useful tool in designing of microfluidic devices for separating nanoparticles from flue gas.

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4-D dielectrophoretic handling of Janus particles in a microfluidic chip

Cited by 30 publications

References 8 publications

Review Article—Dielectrophoresis: Status of the theory, technology, and applications

Review Article—Dielectrophoresis: Status of the theory, technology, and applications

Self-organized internal architectures of chiral micro-particles

Dielectrophoresis Used for Nanoparticle Manipulation in Microfluidic Devices

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