4 Drug-induced pancreatitis

Mallory, Andrew; Kern, Fred

doi:10.1016/0950-3528(88)90005-x

Cited by 58 publications

(35 citation statements)

References 62 publications

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“…No drug was withdrawn because it was suspected as being the cause of the pancreatitis. The established criterion for drug-induced pancreatitis 25 was not met by any patient. Based on documented T-cell counts, concurrent therapy or their time post BMT, all four patients were immunosuppressed at the time of adenovirus isolation and pancreatitis.…”

Section: Discussionmentioning

confidence: 97%

“…As drugs are commonly associated with pancreatitis, the drugs given 30 days before the onset of pancreatitis in these five patients were reviewed. These drugs were divided into one of three groups: 25 in the first group, the drug association seems to be definite, usually from carefully documented studies showing appearance of pancreatitis during treatment with the drug, disappearing when withdrawn and often appearing again when drug was reintroduced. In the second group, an association with pancreatitis is thought probably to exist but reports do not fulfil all the criteria for group 1 and drugs in the third group are thought either not to cause pancreatitis or if proposed, the evidence is inadequate.…”

Section: Methodsmentioning

confidence: 99%

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Pancreatitis and adenoviral infection in children after blood and marrow transplantation

Bateman

Kesson

Shaw

2006

Bone Marrow Transplant

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Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Pancreatitis and adenoviral infection in children after blood and marrow transplantation

Bateman

Kesson

Shaw

2006

Bone Marrow Transplant

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“…Rare but possibly very serious adverse reactions include hepatotoxicity, especially in very young retarded children, and pancreatitis, as observed in our patient. 1,4,5 The incidence of acute pancreatitis in childhood, in general, is estimated at 2.0-2.7 per 100,000 per year. 2 Pancreatitis complicated by pancreatic pseudocysts (a collection of amylase-rich, lipaserich, and enterokinase-rich fluid) in childhood is reported predominantly after abdominal trauma.…”

Section: Discussionmentioning

confidence: 99%

Pancreatitis, complicated by a pancreatic pseudocyst associated with the use of valproic acid

Houben

Wilting

Stroink

et al. 2005

European Journal of Paediatric Neurology

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SummaryA 12-year-old boy developed pancreatitis, complicated by a pancreatic pseudocyst, as an adverse reaction to valproic acid (VPA) treatment for epilepsy. Pancreatitis subsided within three weeks after discontinuation of VPA. The pancreatic pseudocyst was managed without surgery and resolved spontaneously in four weeks. Valproic acid was concluded to be the most probable cause, since no other explanation was found. According to the literature VPA is a rare but known cause of pancreatitis.A computer-assisted literature search revealed seven previously reported cases of VPA-induced pancreatitis complicated by a pancreatic pseudocyst. Six of these patients were under 20 years of age. Four patients were treated conservatively; three needed cystostomy or external drainage. All patients recovered.Patients using VPA, especially children, presenting with acute abdominal pain should be suspected of valproic acid-induced pancreatitis. If VPA induced pancreatitis is complicated by a pseudocyst, conservative treatment should be the first line of treatment. Q 2005 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved. CaseA 12-year-old boy presented at the pediatric ward of our hospital with intermittent upper abdominal pain that started two weeks before. The pain attacks lasted for several minutes, and were less painful when the boy was lying still with his legs flexed. The attacks occurred 4-8 times a day. On examination the boy appeared moderately ill. His body weight was 45 kg and his temperature was 38 8C. He had no signs of jaundice nor did the skin reveal any haematomas. The bowel sounds were normal but there was some left upper abdominal tenderness. The liver and spleen were not enlarged, nor were any abnormal masses felt.

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“…A number of drugs such as azathioprine, glucocorticoids, cyclosporine A, and calcium chloride have been incriminated as causes of pancreatitis. 2,10 All of these are commonly used in liver transplant patients. Ischemic injury, surgical stress, and postoperative hyperparathyroidism have also been incriminated.…”

Section: Discussionmentioning

confidence: 99%

Acute pancreatitis after orthotopic liver transplantation in children

Tissieres¹

1997

Liver Transplantation

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A cute pancreatitis (AP) after orthotopic liver transplantation (OLT) is a rare but severe complication. [1][2][3] In two large adult series, its incidence varies from 3% to 3.6% and mortality ranges from 53.8% to 63.6%. 2,3 To our knowledge, only 4 cases have been previously mentioned in children. 4 To add to this very limited experience, we report 2 cases of AP following OLT and discuss the mechanism of this complication. Pancreatitis occurred during the early postoperative period. The exact cause for AP seems to be multifactorial. These 2 children died of multiple organ failure (MOF).

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4 Drug-induced pancreatitis

Cited by 58 publications

References 62 publications

Pancreatitis and adenoviral infection in children after blood and marrow transplantation

Pancreatitis and adenoviral infection in children after blood and marrow transplantation

Pancreatitis, complicated by a pancreatic pseudocyst associated with the use of valproic acid

Acute pancreatitis after orthotopic liver transplantation in children

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