4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids

Abstract

obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.

Polyhalonitrobutadienes as Versatile Building Blocks for the Biotargeted Synthesis of Substituted N-Heterocyclic Compounds

“…At optimum conditions (MeOH, threefold excess of amino-pyridines, rt), the yields of pyridopyrimidines 33 reached 47-55% (Scheme 9). Similar pyrido[1,2-a]pyrimidines show antiviral [55], antithrombotic [56], and antibacterial [57][58][59][60] activities.…”

Chemistry of polyhalogenated nitrobutadienes, 10: Synthesis of highly functionalized heterocycles with a rigid 6-amino-3-azabicyclo[3.1.0]hexane moiety

“…Therefore, upon treatment with the azabicyclohexane 1 under mild conditions (methanol, rt) the enamine 24 was formed in 86% yield ( Scheme 6 ). Similar pyrido[1,2- a ]pyrimidines show antiviral [ 29 ], antithrombotic [ 30 ] and antibacterial [ 31 – 34 ] activities.…”

One‐Pot Synthesis of 2‐Amino‐6‐(1,2‐dihydro‐4‐hydroxy‐2‐oxoquinolin‐3‐yl)‐4‐arylpyridine‐3‐carbonitriles Catalysed by NbCl5 and Their In Vitro Antimicrobial Studies

“…Quinolones exerts their activity against aerobic Gram‐negatives, some Gram‐positives and anaerobic bacteria by preventing bacterial DNA from unwinding and duplicating . The promising activity by quinolones led the development of numerous newer quinolones of which many were synthesized by simple and flexible synthetic routes . Since then, rarely encountered and less studied 3‐ substituted quinolones have become a subject of great interest to researchers.…”