4-Hydroxycoumarin in heterocyclic synthesis

Facile heterocyclic synthesis and antimicrobial activity of polysubstituted and condensed pyrazolopyranopyrimidine and pyrazolopyranotriazine derivatives

“…In continuation of our study of the chemistry of heterocyclic b-enamino-carbonitrile (1) and the synthesis of fused pyrane ring systems of pharmacological importance (2), pyrane and its fused derivatives have attracted great interest owing to their antimicrobial (3)(4)(5), antiviral (6), antitumor (7), antiproliferactive (8), molluscicidal (9), and anti-inflammatory activities (10). Also, pyrane derivatives are well known antihistaminic agents (11).…”

“…Also, 6-amino-5-cyano-dihydro-pyrano [2,3-c]pyrazoles have been identified as a screening hit for human Chk1 kinase inhibitors (19). We herein report the use of 6-amino-3-methyl-4-(4-florophenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (1) as starting material for the synthesis of a new series of pyrazolopyranopyrimidines (2)(3)(4)(5)(6) and their derivatives 11a,b, pyrazolopyranoquinoline (7) and pyrazolopyranotriazine (8).…”

Heteroaromatization with 4-phenyldiazenyl-1-naphthol. Part III: One-pot synthesis and DFT study of 4H-naphthopyran derivatives

“…Moreover, azo compounds are known for their antineoplastics [13], antidiabetics [14], antiseptics [15], antibacterial [16] and antitumor activities [17]. 4H-Pyran nucleus is a fertile source of biologically important molecules possessing a wide spectrum of biological and pharmacological activities such as antimicrobial [18][19][20][21], inhibitors of influenza virus sialidases [22,23], DNA strand-breaking activity and mutagenicity [24], antiviral agent [25], antiproliferation agent [26], sex pheromone [27], antitumor [28,29] and central nervous system (CNS) activity [18][19][20][21][22][23][24][25][26][27][28][29][30]. The synthesis of 4H-naphthopyrans involves a one-pot three-component coupling reaction of, p-chlorobenzaldehyde, malononitrile or ethyl cyanoacetate and phenyldiazenyl-1-naphthol.…”

Heteroaromatization with 4-phenyldiazenyl-1-naphthol. Part II: Synthesis of some new benzochromens, benzochromenopyrimidines, benzochromenotriazolopyrimidines, benzochromenopyrimidotriazepine and antimicrobial activities

“…Moreover azo compounds are known for their antineoplastics [13], antidiabetics [14], antiseptics [15], antibacterial [16] and antitumor [17]. Benzochromene represent a class of heterocyclic compounds endowed with potent antimicrobial agents [18][19][20][21][22][23], antileishmanial [24,25], anticancer [26,27], antiproliferative [28], antioxidant [29,30], hypertensive [31], antitumor [32][33][34][35] effects and activities, as well as for the treatment of Alzheimer's disease [36], schizophrenia disorders [37], and fused chromene ring systems also displayed blood platelet antiaggregating [38], antihistaminic [39], analgesic [40][41][42], hypolipidemic [43], DNA breaking and mutagenicity activities [44].…”