4-Hz oscillations synchronize prefrontal–amygdala circuits during fear behavior

Karalis, Nikolaos; Déjean, Cyril; Chaudun, Fabrice; Khoder, Suzana; Rozeske, Robert R.; Wurtz, Hélène; Bagur, Sophie; Benchenane, Karim; Sirota, Anton; Courtin, Julien; Herry, Cyril

doi:10.1038/nn.4251

Cited by 364 publications

(431 citation statements)

References 42 publications

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“…The 4 Hz rhythm is most likely independent of respiration because breathing frequency is highly variable during epochs of movement20 (when 4 Hz appears). Similarly, 4 Hz oscillations have been described to pace prefrontal neuronal assemblies during fear-induced freezing3940. Although not tested directly in that study, it is possible that freezing-associated 4 Hz patterns are linked with respiration.…”

Section: Discussionmentioning

confidence: 81%

Organization of prefrontal network activity by respiration-related oscillations

Biskamp

Bartos

Sauer

2017

Sci Rep

187

206

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The medial prefrontal cortex (mPFC) integrates information from cortical and sub-cortical areas and contributes to the planning and initiation of behaviour. A potential mechanism for signal integration in the mPFC lies in the synchronization of neuronal discharges by theta (6–12 Hz) activity patterns. Here we show, using in vivo local field potential (LFP) and single-unit recordings from awake mice, that prominent oscillations in the sub-theta frequency band (1–5 Hz) emerge during awake immobility in the mPFC. These oscillation patterns are distinct from but phase-locked to hippocampal theta activity and occur synchronized with nasal respiration (hence termed prefrontal respiration rhythm [PRR]). PRR activity modulates the amplitude of prefrontal gamma rhythms with greater efficacy than theta oscillations. Furthermore, single-unit discharges of putative pyramidal cells and GABAergic interneurons are entrained by prefrontal PRR and nasal respiration. Our data thus suggest that PRR activity contributes to information processing in the prefrontal neuronal network.

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Section: Discussionmentioning

confidence: 81%

Organization of prefrontal network activity by respiration-related oscillations

Biskamp

Bartos

Sauer

2017

Sci Rep

187

206

View full text Add to dashboard Cite

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“…This finding is in line with animal investigations showing that specific patterns of medial PFC-amygdala correlate with fear expression. 39 These exploratory models highlight the need for studies to further examine such questions with cross-validation techniques in larger sample sizes.…”

Section: Discussionmentioning

confidence: 99%

Skin Conductance Responses and Neural Activations During Fear Conditioning and Extinction Recall Across Anxiety Disorders

et al. 2017

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IMPORTANCEThe fear conditioning and extinction neurocircuitry has been extensively studied in healthy and clinical populations, with a particular focus on posttraumatic stress disorder. Despite significant overlap of symptoms between posttraumatic stress disorder and anxiety disorders, the latter has received less attention. Given that dysregulated fear levels characterize anxiety disorders, examining the neural correlates of fear and extinction learning may shed light on the pathogenesis of underlying anxiety disorders.OBJECTIVES To investigate the psychophysiological and neural correlates of fear conditioning and extinction recall in anxiety disorders and to document how these features differ as a function of multiple diagnoses or anxiety severity. DESIGN, SETTING, AND PARTICIPANTSThis investigation was a cross-sectional, case-control, functional magnetic resonance imaging study at an academic medical center. Participants were healthy controls and individuals with at least 1 of the following anxiety disorders: generalized anxiety disorder, social anxiety disorder, specific phobia, and panic disorder. The study dates were between March 2013 and May 2015.EXPOSURES Two-day fear conditioning and extinction paradigm. CONCLUSIONS AND RELEVANCE Despite no skin conductance response group differences during extinction recall, brain activation patterns between anxious and healthy individuals differed. These findings encourage future studies to examine the conditions longitudinally and in the context of treatment trials to improve and guide therapeutics via advanced neurobiological understanding of each disorder.

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“…extinction (Baeg et al, 2001, Milad and Quirk, 2002, Burgos-Robles et al, 2009, Courtin et al, 2014). Moreover, the PFC interacts with other regions such as the amygdala and the ventral and dorsal hippocampus via pair-wise neuronal correlations and synchrony – particularly theta oscillations – to regulate conditioned fear responses and explorative behavior in anxiogenic environments such as the open field test and the elevated plus maze test (Adhikari et al, 2010, Lesting et al, 2011, Livneh and Paz, 2012, Kumar et al, 2014, Likhtik et al, 2014, Karalis et al, 2016). …”

Section: Impact Of Anxiety On Cognitive Flexibilitymentioning

confidence: 99%

Impact of anxiety on prefrontal cortex encoding of cognitive flexibility

2017

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Anxiety often is studied as a stand-alone construct in laboratory models. But in the context of coping with real-life anxiety, its negative impacts extend beyond aversive feelings and involve disruptions in ongoing goal-directed behaviors and cognitive functioning. Critical examples of cognitive constructs affected by anxiety are cognitive flexibility and decision making. In particular, anxiety impedes the ability to shift flexibly between strategies in response to changes in task demands, as well as the ability to maintain a strategy in the presence of distractors. The brain region most critically involved in behavioral flexibility is the prefrontal cortex (PFC), but little is known about how anxiety impacts PFC encoding of internal and external events that are critical for flexible behavior. Here we review animal and human neurophysiological and neuroimaging studies implicating PFC neural processing in anxiety-induced deficits in cognitive flexibility. We then suggest experimental and analytical approaches for future studies to gain a better mechanistic understanding of impaired cognitive inflexibility in anxiety and related disorders.

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4-Hz oscillations synchronize prefrontal–amygdala circuits during fear behavior

Cited by 364 publications

References 42 publications

Organization of prefrontal network activity by respiration-related oscillations

Organization of prefrontal network activity by respiration-related oscillations

Skin Conductance Responses and Neural Activations During Fear Conditioning and Extinction Recall Across Anxiety Disorders

Impact of anxiety on prefrontal cortex encoding of cognitive flexibility

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