4-Iodoantipyrine synthesized by means of solid-state mechanical activation

Abstract

Antipyrine and its benzenesulfonate were iodinated by solid-state mechanical activation (in the absence of solvent) under the action of iodine, iodine chloride, Me 4 N + ICl 2 -, and Et 4 N + ICl 2 -with the formation of 4-iodoantipyrine. The proposed process does not require organic solvents and meets all Green Chemistry demands. The best results were achieved with the use of tetraalkylammonium salts Me 4 N + ICl 2 -and Et 4 N + ICl 2 -.

Solvent-Free and Liquid-Phase Iodination of Thiophene Derivatives with Potassium Dichloroiodate Monohydrate

“…20 In addition, KICl 2 and its tetraalkylammonium counterparts are capable for solvent-free iodination. 20,22 Potassium dichloroiodate has been used for the iodination of urea, 23 arenes, 24 and heterocyclic compounds. 21b Here we report on potassium dichloroiodate as a new reagent for the electrophilic iodination of thiophene derivatives.…”