4-Mercaptobenzoic Acid Labeled Gold-Silver-Alloy-Embedded Silica Nanoparticles as an Internal Standard Containing Nanostructures for Sensitive Quantitative Thiram Detection

Pham, Xuan‐Hung; Hahm, Eunil; Huynh, Kim-Hung; Son, Byung Sung; Kim, Hyungmo; Jeong, Dae Hong; Jun, Bong‐Hyun

doi:10.3390/ijms20194841

Cited by 43 publications

(36 citation statements)

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“…To prepare SiO 2 nanostructure (SiO 2 @Au), silica NPs (~150 nm) were first functionalized by 3-aminopropyltriethoxysilane (APTS) to prepare aminated silica NPs, as shown in Figure 1 a. Simultaneously, colloidal Au NPs (3 nm) were synthesized by tetrakis(hydroxymethyl)phosphonium chloride (THPC) and incubated with the aminated silica NPs to prepare Au NPs seed embedded with SiO 2 (SiO 2 @Au seed NPs), according to the method reported by Pham et al [ 32 , 33 , 34 , 35 , 39 ]. Subsequently, the Au NPs on the surface of SiO 2 @Au seed were grown by reducing a gold precursor (HAuCl 4 ) in the presence of ascorbic acid (AA) and polyvinylpyrrolidone (PVP) as a stabilizer and structure-directing agent under mild reducing conditions [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…The density of the Au NPs and the gaps between two Au NPs on the surface of SiO 2 can be tunable and provide a stronger localized surface plasmon resonance (LSPR) property. As a result, SiO 2 @Au–Ag can be developed as high-strength and reliable SERS substrates for the enzyme-linked immunosorbent assay (ELISA) [ 37 , 38 ], which is an internal SERS [ 34 , 35 ], pesticide detection standard [ 39 ], and provides detection of toxic chemical compound in pharmaceutics [ 40 ]. However, the cellular toxicity and easy oxidation of intrinsic Ag of our nanostructure limits their application in vivo [ 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Densely Immobilized Gold-Assembled Silica Nanostructures

Seong

Bock

Hahm

et al. 2021

IJMS

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In this study, dense gold-assembled SiO2 nanostructure (SiO2@Au) was successfully developed using the Au seed-mediated growth. First, SiO2 (150 nm) was prepared, modified by amino groups, and incubated by gold nanoparticles (ca. 3 nm Au metal nanoparticles (NPs)) to immobilize Au NPs to SiO2 surface. Then, Au NPs were grown on the prepared SiO2@Au seed by reducing chloroauric acid (HAuCl4) by ascorbic acid (AA) in the presence of polyvinylpyrrolidone (PVP). The presence of bigger (ca. 20 nm) Au NPs on the SiO2 surface was confirmed by transmittance electronic microscopy (TEM) images, color changes to dark blue, and UV-vis spectra broadening in the range of 450 to 750 nm. The SiO2@Au nanostructure showed several advantages compared to the hydrofluoric acid (HF)-treated SiO2@Au, such as easy separation, surface modification stability by 11-mercaptopundecanoic acid (R-COOH), 11-mercapto-1-undecanol (R-OH), and 1-undecanethiol (R-CH3), and a better peroxidase-like catalysis activity for 5,5′-Tetramethylbenzidine (TMB) and hydrogen peroxide (H2O2) reaction. The catalytic activity of SiO2@Au was two times better than that of HF-treated SiO2@Au. When SiO2@Au nanostructure was used as a surface enhanced Raman scattering (SERS) substrate, the signal of 4-aminophenol (4-ATP) on the surface of SiO2@Au was also stronger than that of HF-treated SiO2@Au. This study provides a potential method for nanoparticle preparation which can be replaced for Au NPs in further research and development.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis of Densely Immobilized Gold-Assembled Silica Nanostructures

Seong

Bock

Hahm

et al. 2021

IJMS

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“…The SiO 2 @Au@Ag NP material was prepared based on studies conducted by the Pham group revealing that SiO 2 @Au@Ag NPs exhibit a high Raman enhancement effect [39,43,44]. Silica NPs were produced using the Stöber method.…”

Section: Characterization Of the Sio 2 @Au@ag Npsmentioning

confidence: 99%

Facile Histamine Detection by Surface-Enhanced Raman Scattering Using SiO2@Au@Ag Alloy Nanoparticles

Huynh

Pham

Hahm

et al. 2020

IJMS

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Histamine intoxication associated with seafood consumption represents a global health problem. The consumption of high concentrations of histamine can cause illnesses ranging from light symptoms, such as a prickling sensation, to death. In this study, gold–silver alloy-embedded silica (SiO2@Au@Ag) nanoparticles were created to detect histamine using surface-enhanced Raman scattering (SERS). The optimal histamine SERS signal was measured following incubation with 125 μg/mL of SiO2@Au@Ag for 2 h, with a material-to-histamine solution volume ratio of 1:5 and a phosphate-buffered saline-Tween 20 (PBS-T) solvent at pH 7. The SERS intensity of the histamine increased proportionally with the increase in histamine concentration in the range 0.1–0.8 mM, with a limit of detection of 3.698 ppm. Our findings demonstrate the applicability of SERS using nanomaterials for histamine detection. In addition, this study demonstrates that nanoalloys could have a broad application in the future.

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“…As a result, a high-strength and reliable SiO 2 @Au@Ag based-SERS substrates with high reproducibility and 4.2 × 10 6 fold-enhancement as compared to without the nanomaterial was developed for the enzyme-linked immunosorbent assay (ELISA) [ 40 , 41 ]. Simultaneously, a Raman reporter was also immobilized between the Au and Ag layer to play the role of an internal standard for the accurate detection of the pesticide thiram [ 42 , 43 , 44 ]. However, their use in SERS detection for glucose requires further investigation.…”

Section: Introductionmentioning

confidence: 99%

Glucose Detection of 4-Mercaptophenylboronic Acid-Immobilized Gold-Silver Core-Shell Assembled Silica Nanostructure by Surface Enhanced Raman Scattering

et al. 2021

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The importance of glucose in many biological processes continues to garner increasing research interest in the design and development of efficient biotechnology for the sensitive and selective monitoring of glucose. Here we report on a surface-enhanced Raman scattering (SERS) detection of 4-mercaptophenyl boronic acid (4-MPBA)-immobilized gold-silver core-shell assembled silica nanostructure (SiO2@Au@Ag@4-MPBA) for quantitative, selective detection of glucose in physiologically relevant concentration. This work confirmed that 4-MPBA converted to 4-mercaptophenol (4-MPhOH) in the presence of H2O2. In addition, a calibration curve for H2O2 detection of 0.3 µg/mL was successfully detected in the range of 1.0 to 1000 µg/mL. Moreover, the SiO2@Au@Ag@4-MPBA for glucose detection was developed in the presence of glucose oxidase (GOx) at the optimized condition of 100 µg/mL GOx with 1-h incubation time using 20 µg/mL SiO2@Au@Ag@4-MPBA and measuring Raman signal at 67 µg/mL SiO2@Au@Ag. At the optimized condition, the calibration curve in the range of 0.5 to 8.0 mM was successfully developed with an LOD of 0.15 mM. Based on those strategies, the SERS detection of glucose can be achieved in the physiologically relevant concentration range and opened a great promise to develop a SERS-based biosensor for a variety of biomedicine applications.

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4-Mercaptobenzoic Acid Labeled Gold-Silver-Alloy-Embedded Silica Nanoparticles as an Internal Standard Containing Nanostructures for Sensitive Quantitative Thiram Detection

Cited by 43 publications

References 43 publications

Synthesis of Densely Immobilized Gold-Assembled Silica Nanostructures

Synthesis of Densely Immobilized Gold-Assembled Silica Nanostructures

Facile Histamine Detection by Surface-Enhanced Raman Scattering Using SiO2@Au@Ag Alloy Nanoparticles

Glucose Detection of 4-Mercaptophenylboronic Acid-Immobilized Gold-Silver Core-Shell Assembled Silica Nanostructure by Surface Enhanced Raman Scattering

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