(4-Methoxy-benzo[1,3]dioxol-5-yl)- &lt;i&gt; Phenylmethanone&lt;/i&gt;: an antibacterial benzophenone from securidaca longepedunculata

Joseph, Cosam C.; Moshi, Mainen J.; Sempombe, Joseph; Nkunya, Mayunga H.H.

doi:10.4314/ajtcam.v3i3.31169

Cited by 15 publications

(17 citation statements)

References 13 publications

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“…Isoprenylated xanthones, toxyloxanthone C (27), and wighteone (28) showed antifungal activity against C. albicans with MIC values of 25 and 12.5 mg/ml, respectively [49]. The dichloromethane extract of Securidaca longepedunculata yielded 1,7-dihydroxy-4-methoxyxanthone (29) which exhibited antibacterial activity against Staphylococcus aureus and antifungal activity against A. niger, A. fumigatus, and a Penicillum species [50].…”

Section: Xanthonesmentioning

confidence: 98%

Natural products – antifungal agents derived from plants

Arif

Bhosale

Kumar

et al. 2009

Journal of Asian Natural Products Research

319

181

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A new spectrum of human fungal infections is increasing due to increased cancer, AIDS, and immunocompromised patients. The increased use of antifungal agents also resulted in the development of resistance to the present drugs. It makes necessary to discover new classes of antifungal compounds to cure fungal infections. Plants are rich source of bioactive secondary metabolites of wide variety such as tannins, terpenoids, saponins, alkaloids, flavonoids, and other compounds, reported to have in vitro antifungal properties. Since the plant kingdom provides a useful source of lead compounds of novel structure, a wide-scale investigation of species from the tropics has been considered. Therefore, the research on natural products and compounds derived from natural products has accelerated in recent years due to their importance in drug discovery. A series of molecules with antifungal activity against different strains of fungus have been found in plants, which are of great importance to humans. These molecules may be used directly or considered as a precursor for developing better molecules. This review attempts to summarize the current status of important antifungal compounds from plants.

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Section: Xanthonesmentioning

confidence: 98%

Natural products – antifungal agents derived from plants

Arif

Bhosale

Kumar

et al. 2009

Journal of Asian Natural Products Research

319

181

View full text Add to dashboard Cite

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“…General experimental procedures: CC: silica gel 60 (0.063-0.200 mm, Merck); TLC: silica gel 60 F 254 (Merck) precoated plastic plates; visualization: UV-Vis and anisaldehyde spray [9]; IR: CHCl 3 or KBr; specific Diterpenoids and a chlorobenzenoid from Tessmannia martiniana Natural Product Communications Vol. 5 (2) 2010 177 Biological assay: Larvicidal, antibacterial and antifungal assays were carried out as reported in the literature [10][11][12]. In the larvicidal assays 20 late 3 rd or young 4 th instar larvae of Anopheles gambiae s.s were used per beaker with 3 beakers per concentration (the water temperature being 25 ± 1°C) and for each test 3 beakers containing distilled water and test larvae, but without sample, were used as controls.…”

Section: Methodsmentioning

confidence: 99%

“…These results further demonstrate the versatility of the family Caesalpiniaceae in accumulating bioactive metabolites of interest to biomedical research. Biological assay: Larvicidal, antibacterial and antifungal assays were carried out as reported in the literature [10][11][12]. In the larvicidal assays 20 late 3 rd or young 4 th instar larvae of Anopheles gambiae s.s were used per beaker with 3 beakers per concentration (the water temperature being 25 ± 1°C) and for each test 3 beakers containing distilled water and test larvae, but without sample, were used as controls.…”

mentioning

confidence: 99%

Antimosquito and Antimicrobial Clerodanoids and a Chlorobenzenoid from Tessmannia species

Kihampa

Nkunya

Joseph

et al. 2010

Natural Product Communications

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The clerodane diterpenoids trans-kolavenolic acid, 18-oxocleroda-3,13(E)-dien-15-oic acid, ent-(18-hydroxycarbonyl)-cleroda-3,13(E)-dien-15-oate, 2-oxo-ent-cleroda-3,13(Z)-dien-15-oic acid and trans-2-oxo-ent-cleroda-13(Z)-en-15-oic acid, and the chlorobenzenoid O-(3-hydroxy-4-hydroxycarbonyl-5-pentylphenyl)-3-chloro-4-methoxy-6-pentyl-2-oxybenzoic acid were isolated from Tessmannia martiniana var pauloi and T. martiniana var matiniana. Structures were established based on interpretation of spectroscopic data. Some of the compounds exhibited significant antimosquito, antifungal and antibacterial activities.

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“…Securidaca longipedunculata est une plante largement utilisée en médecine traditionnelle africaine dans la prise en charge de nombreuses maladies incluant l'inflammation, les maux de tête, la polyarthrite rhumatoïde, le rhumatisme chronique, les douleurs abdominales etc. (Joseph et al, 2006). Les feuilles et les écorces de racines sont les organes les plus utilisés entre autres dans le traitement de la polyarthrite rhumatoïde, le rhumatisme chronique (OOAS, 2013).…”

Section: Introductionunclassified

Etude Phytochimique Des Écorces De Racines Et Des Feuilles De Securidaca longipedunculata (Fresen), Polygalaceae Au Mali

Haïdara

Dénou

et al. 2021

ESJ

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Securidaca longipedunculata est une plante largement utilisée en Médecine Traditionnelle Africaine. L’objectif de ce travail est de caractériser les constituants chimiques et anti-radicalaires des feuilles et des écorces de racines de la plante. Les échantillons ont été récoltés et contrôlés, des extraits ont été préparés et les rendements déterminés, les constituants ont été caractérisés par des réactions colorées et de précipitation et par la chromatographie sur couche mince. Les caractères macroscopiques des organes sont entre autres : lisse, épaisse et jaune clair, tortueuse, rugueuse avec une odeur caractéristique pour l’écorce et la racine ; alternes, entières, simples, oblongues-elliptiques, sommet arrondi avec un pétiole mince pour les feuilles. La poudre des échantillons est de couleur blanche sale, d’odeur forte repoussante et de saveur piquante pour les écorces de racines ; couleur verdâtre, odeur faible non repoussante et de saveur légèrement piquante pour les feuilles. Le meilleur rendement de l’extraction est 33,24% pour le décocté 20% des écorces de racines et 36,37% pour l’extrait hydroalcoolique de feuilles. Les constituants chimiques communs aux deux organes sont les composés triterpéniques et les coumarines ; plus particulièrement les flavonoïdes, tanins et les alcaloïdes sont les constituants majoritaires des feuilles. En plus les mucilages, oses et holosides sont modérément présents dans les deux organes. La richesse des échantillons des deux organes en ses constituants peut justifier certaines utilisations traditionnelles de la plante. Securidaca longipedunculata is a plant widely used in African Traditional Medicine. The objective of this work was to characterize the chemical constituents of the leaves and root bark of the plant. Samples were collected and checked, extracts were prepared and the yield were determined. The chemical and anti-free radical constituents were characterized by color and precipitation reactions and by thin layer chromatography. The macroscopic characters of the organs are, among others: smooth, thick and light yellow, twisted, rough with a characteristic odor to the root bark; alternate, entire, simple, oblong-elliptical, rounded top and a thin petiole for the leaves. The powder of the samples is dirty white, with a strong repulsive odor and pungent flavor for the root bark; greenish color, faint non-repulsive odor and slightly pungent flavor for the leaves. The best extraction yield was 33.24% for the aqueous extract 20% of the root bark and 36.37% for the hydroalcoholic extract of the leaves. The chemical constituents common to both organs are triterpene compounds and coumarins; while flavonoids, tannins and alkaloids are the major constituents of the leaves. In addition, mucilages, oses and holosides are moderately present in both organs. Samples from both organs were found to be rich in anti-free radical constituents. The richness of organ samples in these constituents may justify certain traditional uses of the plant.

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(4-Methoxy-benzo[1,3]dioxol-5-yl)- <i> Phenylmethanone</i>: an antibacterial benzophenone from securidaca longepedunculata

Cited by 15 publications

References 13 publications

Natural products – antifungal agents derived from plants

Natural products – antifungal agents derived from plants

Antimosquito and Antimicrobial Clerodanoids and a Chlorobenzenoid from Tessmannia species

Etude Phytochimique Des Écorces De Racines Et Des Feuilles De Securidaca longipedunculata (Fresen), Polygalaceae Au Mali

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