4-methoxybenzalacetone, the cinnamic acid analog as a potential quorum sensing inhibitor against Chromobacterium violaceum and Pseudomonas aeruginosa

Jantaruk, Pornpimon; Pabuprapap, Wachirachai; Nakaew, Archawin; Kunthalert, Duangkamol; Suksamrarn, Apichart

doi:10.1007/s11274-021-03119-x

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…Pyocyanin production by PAO1 and PAO1::vfr was measured as described previously [40]. In brief, overnight bacterial culture was diluted to 1 × 10 6 CFU/mL in ABTGC containing 1 μM Me 3 PAuCl or DMSO, and cultivated at 37 °C with shaking for 24 h. The bacterial culture was centrifuged at 8000 g for 10 min to collect the supernatant.…”

Section: Pyocyanin Assaymentioning

confidence: 99%

Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr

Zhang¹,

Chew²,

Wang³

et al. 2023

Computational and Structural Biotechnology Journal

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Section: Pyocyanin Assaymentioning

confidence: 99%

Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr

Zhang¹,

Chew²,

Wang³

et al. 2023

Computational and Structural Biotechnology Journal

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“…Compounds with a benzene ring such as three hydrazine-carboxamide hybrid derivatives 5 7a – c and the synthetic molecule isoeugenol ( Figure 18 a) show anti-biofilm activity against P. aeruginosa [ 137 , 138 ]. Additionally, a benzalacetone analog 4-methoxybenzalacetone shows the suppression of some virulence phenotypes of P. aeruginosa [ 139 ]. Studies reported that the indole derivatives 7-fluoroindole, 7-hydroxyindole, and 3-indolylacetonitrile ( Figure 18 a) were potent antivirulence compounds.…”

Section: Inhibition Mechanism Undeterminedmentioning

confidence: 99%

The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors

Shen

Wang

et al. 2022

Marine Drugs

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The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic activity is one of the important inducements for bacteria to develop drug resistance. Bacteria gain drug resistance through spontaneous mutation so as to achieve the goals of survival and reproduction. Quorum sensing (QS) is an intercellular communication system based on cell density that can regulate bacterial virulence and biofilm formation. The secretion of more than 30 virulence factors of P. aeruginosa is controlled by QS, and the formation and diffusion of biofilm is an important mechanism causing the multidrug resistance of P. aeruginosa, which is also closely related to the QS system. There are three main QS systems in P. aeruginosa: las system, rhl system, and pqs system. Quorum-sensing inhibitors (QSIs) can reduce the toxicity of bacteria without affecting the growth and enhance the sensitivity of bacterial biofilms to antibiotic treatment. These characteristics make QSIs a popular topic for research and development in the field of anti-infection. This paper reviews the research progress of the P. aeruginosa quorum-sensing system and QSIs, targeting three QS systems, which will provide help for the future research and development of novel quorum-sensing inhibitors.

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“…Bacterial infection is the leading cause of human death, and people often use antibiotics to kill pathogens. Unfortunately, due to the overuse and abuse of antibiotics, the resistance of bacteria to existing antibiotics is increasing [5,6]; therefore, it is urgent to find a new method to deal with drug-resistant bacteria. The regulation of the QS system, an important intercellular communication system, is performed by the release of autoinducers (AIs).…”

Section: Introductionmentioning

confidence: 99%

Research Progress on the Combination of Quorum-Sensing Inhibitors and Antibiotics against Bacterial Resistance

Wang,

Lu,

Wang

et al. 2024

Molecules

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Bacterial virulence factors and biofilm development can be controlled by the quorum-sensing (QS) system, which is also intimately linked to antibiotic resistance in bacteria. In previous studies, many researchers found that quorum-sensing inhibitors (QSIs) can affect the development of bacterial biofilms and prevent the synthesis of many virulence factors. However, QSIs alone have a limited ability to suppress bacteria. Fortunately, when QSIs are combined with antibiotics, they have a better therapeutic effect, and it has even been demonstrated that the two together have a synergistic antibacterial effect, which not only ensures bactericidal efficiency but also avoids the resistance caused by excessive use of antibiotics. In addition, some progress has been made through in vivo studies on the combination of QSIs and antibiotics. This article mainly expounds on the specific effect of QSIs combined with antibiotics on bacteria and the combined antibacterial mechanism of some QSIs and antibiotics. These studies will provide new strategies and means for the clinical treatment of bacterial infections in the future.

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4-methoxybenzalacetone, the cinnamic acid analog as a potential quorum sensing inhibitor against Chromobacterium violaceum and Pseudomonas aeruginosa

Cited by 5 publications

References 44 publications

Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr

Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr

The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors

Research Progress on the Combination of Quorum-Sensing Inhibitors and Antibiotics against Bacterial Resistance

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