4‐O‐methylhonokiol Inhibits Serious Embryo Anomalies Caused by Nicotine via Modulations of Oxidative Stress, Apoptosis, and Inflammation

Cai, Lin; Yon, Jung-Min; Hong, Jin Tae; Lee, Jong Kwon; Jeong, Jayoung; Baek, In-Jeoung; Lee, Beom Jun; Yun, Young Won; Nam, Sang-Yoon

doi:10.1002/bdrb.21092

Cited by 14 publications

(10 citation statements)

References 47 publications

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“…This response could alter signal transduction pathways, damage macro-molecules, produce vasoactive compounds (e.g., isoprostanes), alter both placental morphology (e.g., placental calcification) and blood flow, and contribute to intrauterine growth retardation and low birth weight (Hutter et al 2010; Stone et al 2014). Additional evidence suggests the possibility of inflammatory pathways (Lin et al 2014; Pringle et al 2015) and epigenetic modifications (Knopik et al 2012), but the mechanisms by which these effects are transmitted is poorly understood. Considerably more research, particularly prospective, genetically informed, and carefully designed animal and human studies that can address critical/sensitive periods of exposure, measurements or biomarkers of exposure effects (e.g., placental tissue) and longitudinal course of disease and behavior is needed to begin to disentangle the likely complex nature of this association.…”

Section: Discussionmentioning

confidence: 99%

Maternal Smoking During Pregnancy and Offspring Birth Weight: A Genetically-Informed Approach Comparing Multiple Raters

et al. 2015

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Maternal smoking during pregnancy (SDP) is a significant public health concern with adverse consequences to the health and well-being of the fetus. There is considerable debate about the best method of assessing SDP, including birth/medical records, timeline follow-back approaches, multiple reporters, and biological verification (e.g., cotinine). This is particularly salient for genetically-informed approaches where it is not always possible or practical to do a prospective study starting during the prenatal period when concurrent biological specimen samples can be collected with ease. In a sample of families (N = 173) specifically selected for sibling pairs discordant for prenatal smoking exposure, we: (1) compare rates of agreement across different types of report—maternal report of SDP, paternal report of maternal SDP, and SDP contained on birth records from the Department of Vital Statistics; (2) examine whether SDP is predictive of birth weight outcomes using our best SDP report as identified via step (1); and (3) use a sibling-comparison approach that controls for genetic and familial influences that siblings share in order to assess the effects of SDP on birth weight. Results show high agreement between reporters and support the utility of retrospective report of SDP. Further, we replicate a causal association between SDP and birth weight, wherein SDP results in reduced birth weight even when accounting for genetic and familial confounding factors via a sibling comparison approach.

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Section: Discussionmentioning

confidence: 99%

Maternal Smoking During Pregnancy and Offspring Birth Weight: A Genetically-Informed Approach Comparing Multiple Raters

et al. 2015

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“…Anatomopathological studies of umbilical cords and placentas of newborn infants from mothers who are smokers demonstrate that tobacco increases the release of vasoactive substances and decreases the release of vasodilator substances such as nitric oxide (NO) [ 47 , 48 ], contributing further to oxidative stress, shear stress, hypoxia and inflammation [ 13 , 49 ]. Based on a large number of studies in animal models, these four types of stimuli can drive a compensatory adaptive structural change known as outward vascular remodeling [ 50 - 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has become evident that oxidative stress is one of the most important mechanisms involved in tobacco smoking during pregnancy [ 6 , 10 , 12 , 13 ]. The increase in reactive oxygen species (ROS) production from exogenous and endogenous sources results in an imbalance between the generation of oxidant species and antioxidant defenses [ 14 - 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of tobacco smoking during pregnancy on oxidative stress in the umbilical cord and mononuclear blood cells of neonates

et al. 2014

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BackgroundAlthough cigarette smoke is known to be a complex mixture of over 4000 substances that can lead to damage through active or passive smoking, its mechanisms and biochemical consequences in pregnancy and neonates are not yet fully understood. Therefore, in the present study, we propose to study the impact of smoking during gestation on the viability of blood mononuclear cells (MNC) from umbilical cords of newborns to assess the degree of oxidative stress and cell viability. After childbirth, the cord blood and the umbilical cord were immediately collected in public hospitals in Greater Vitoria, ES, Brazil. Flow cytometry was used to analyze the cord blood followed by biochemical and histological tests to analyze possible changes in the umbilical cord.ResultsPregnant smokers had a reduction of MNC viability from the umbilical cord (10%), an increase in the production of reactive oxygen species (ROS) and an increase in cell apoptosis (~2-fold) compared to pregnant non-smokers. In the umbilical cord, it was observed an increase of advanced oxidation protein products - AOPP (~2.5-fold) and a loss of the typical architecture and disposition of endothelial cells from the umbilical artery.ConclusionsThese data suggest that maternal cigarette smoking during pregnancy (even in small amounts) may compromise the viability of MNC cells and damage the umbilical cord structure, possibly by excessive ROS bioavailability.

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“…Rodents exposed to nicotine in utero had significantly increased circulating serum pro-inflammatory cytokines (e.g., IL1b, IL6, and TNFa) throughout early development and adulthood (Mohsenzadeh et al 2014, Orellana et al 2014. Similarly, embryos exposed to nicotine had increased gene expression of TNFa and IL1b (Lin et al 2014). Importantly, these cytokines play key roles in germ cell survival and gonadal steroidogenesis (Bornstein et al 2004, Perez et al 2013, Field et al 2014.…”

Section: The Role Of Inflammationmentioning

confidence: 99%

Adverse effects of perinatal nicotine exposure on reproductive outcomes

Wong¹,

Barra²,

Alfaidy³

et al. 2015

Reproduction

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Nicotine exposure during pregnancy through cigarette smoking, nicotine replacement therapies or e-cigarette use continues to be a widespread public health problem, impacting both fetal and postnatal health. Yet, at this time, there remains limited data regarding the safety and efficacy in using these nicotine products during pregnancy. Notably, reports assessing the effect of nicotine exposure on postnatal health outcomes in humans, including reproductive health, are severely lacking. Our current understanding regarding the consequences of nicotine exposure during pregnancy is limited to a few animal studies, which do not comprehensively address the underlying cellular mechanisms involved. This paper aims to critically review the current knowledge from human and animal studies regarding the direct and indirect effects (e.g. obesity) of maternal nicotine exposure, regardless of its source, on reproductive outcomes in pregnancy and postnatal life. Furthermore, this review highlights several key cellular mechanisms involved in these adverse reproductive deficits including oxidative stress, inflammation, and endoplasmic reticulum (ER) stress. By understanding the interplay of the cellular mechanisms involved, further strategies could be developed to prevent the reproductive abnormalities resulting from exposure to nicotine in utero and influence informed clinical guidelines for pregnant women.Reproduction (2015) 150 R185-R193

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4‐O‐methylhonokiol Inhibits Serious Embryo Anomalies Caused by Nicotine via Modulations of Oxidative Stress, Apoptosis, and Inflammation

Cited by 14 publications

References 47 publications

Maternal Smoking During Pregnancy and Offspring Birth Weight: A Genetically-Informed Approach Comparing Multiple Raters

Maternal Smoking During Pregnancy and Offspring Birth Weight: A Genetically-Informed Approach Comparing Multiple Raters

Effects of tobacco smoking during pregnancy on oxidative stress in the umbilical cord and mononuclear blood cells of neonates

Adverse effects of perinatal nicotine exposure on reproductive outcomes

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