4-Octyl itaconate modified demineralized bone matrix scaffold improves bone repair by regulating early inflammation

Qiao, Fangyu; Dong, Chanjuan; Yao, Dongdong; Xu, Zhiling; Lv, Yonggang

doi:10.1016/j.cej.2021.131490

Cited by 15 publications

(16 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result showed that SP@(TA-GS/PF)*3 could modulate the microenvironment of enhanced anti-inflammatory ability, which was a favorable situation for bone integration under the condition of bone defects with or without bacterial infection. 60 The in vivo immunohistochemical analysis indicated that the prepared SP@(TA-GS/PF)*3 both enabled immuno-modification and promoted angiogenesis for boosted diabetic osseointegration. 61 3.10.…”

Section: In Vivo Evaluationmentioning

confidence: 94%

Decorated Polyetheretherketone Implants with Antibacterial and Antioxidative Effects through Layer-by-Layer Nanoarchitectonics Facilitate Diabetic Bone Integration with Infection

Huang

Lin

Bai

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Patients suffering diabetic bone defects still need some new and effective strategies to achieve enhanced prognostic effects. Although medical implants are the common treatment of bone defects, the excessive oxidative stress and high risk of bacterial infection in diabetes mellitus lead to a higher risk of implant failure. To improve the healing ability of diabetic bone defects, herein, polyetheretherketone (PEEK) was modified through a developed layer-by-layer (LBL) construction strategy to obtain multifunctional PEEK (SP@(TA-GS/PF)*3) by the assembly of tannic acid (TA), gentamicin sulfate (GS) and Pluronic F127 (PF127) on the basis of prepared porous PEEK through sulfonation (SPEEK). The prepared SP@(TA-GS/PF)*3 exhibited sustained antimicrobial activity and enhanced the differentiation of osteoblast (MC3T3-E1) for needed osteogenesis. Moreover, SP@(TA-GS/PF)*3 scavenged excessive oxidative stress to promote the growth of H 2 O 2 damaged HUVEC with enhanced secretion of VEGF for neovascularization. In addition, the remarkable in vivo outcomes of angiogenesis and osseointegration were revealed by the subcutaneous implant model and bone tissue implant model in diabetic rats, respectively. The in vitro and in vivo results demonstrated that modified PEEK with multifunction can be an attractive tool for enhancing bone integration under diabetic conditions, underpinning the clinical application potential of modified implants for diabetic osseointegration.

show abstract

Section: In Vivo Evaluationmentioning

confidence: 94%

Decorated Polyetheretherketone Implants with Antibacterial and Antioxidative Effects through Layer-by-Layer Nanoarchitectonics Facilitate Diabetic Bone Integration with Infection

Huang

Lin

Bai

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…In addition, some scientists started using itaconate as a biomaterial to produce an anti-inflammatory effect. For example, itaconate has been used to coat demineralized bone matrix scaffolds to generate integrated scaffolds that participate in bone repair [ 53 ]. In addition, they used itaconate to prepare PCL nanofibres and implanted the nanofibres into mice to maintain the inflammatory response in damaged areas through their proinflammatory effects in the early stage.…”

Section: Itaconate and Its Derivativesmentioning

confidence: 99%

The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases

Shi¹,

Zhou²,

Wei³

et al. 2022

Redox Biology

View full text Add to dashboard Cite

“…This study chose a small molecule drug 4-octylitaconic acid (4-OI) that can regulate and activate the immune metabolic rearrangement function of macrophages. 12 It is a derivative of the natural metabolite of macrophages. 13 It has antioxidant and anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

Injectable hydrogel loaded with 4-octyl itaconate enhances cartilage regeneration by regulating macrophage polarization

et al. 2023

View full text Add to dashboard Cite

show abstract

4-Octyl itaconate modified demineralized bone matrix scaffold improves bone repair by regulating early inflammation

Cited by 15 publications

References 58 publications

Decorated Polyetheretherketone Implants with Antibacterial and Antioxidative Effects through Layer-by-Layer Nanoarchitectonics Facilitate Diabetic Bone Integration with Infection

Decorated Polyetheretherketone Implants with Antibacterial and Antioxidative Effects through Layer-by-Layer Nanoarchitectonics Facilitate Diabetic Bone Integration with Infection

The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases

Injectable hydrogel loaded with 4-octyl itaconate enhances cartilage regeneration by regulating macrophage polarization

Contact Info

Product

Resources

About