4-Phenyloxazolidin-2-ones and isoindolin-1-ones: chiral auxiliaries for Diels–Alder reactions of N-substituted 1,3-dienes

Approach to Isoindolinones, Isoquinolinones, and THIQs via Lewis Acid-Catalyzed Domino Strecker-Lactamization/Alkylations

“…Approaches in literature for isoindolinone synthesis include Heck cyclization, Diels–Alder approach, ring-closure of hydrazones, reactions of acyliminium ion, exploiting carbanion methodology, and various enantioselective approaches including our recent domino Cu­(I)-catalyzed enantioselective propargylation/lactamization and organocatalytic Mannich/lactamization sequence . On the other hand, synthesis of isoquinolines involves various diastereoselective processes , and catalytic enantioselective processes. , Although some elegant approaches to these targets have been reported, still there exist a fewer number of reports to synthesize them applying a general catalytic route.…”