4-Phenylselenyl-7-chloroquinoline, a new quinoline derivative containing selenium, has potential antinociceptive and anti-inflammatory actions

Antioxidant effect of quinoline derivatives containing or not selenium: Relationship with antinociceptive action quinolines are antioxidant and antinociceptive

“…The late phase, which is inflammatory, is mediated by the release of inflammatory mediators, such as nitric oxide, excitatory amino acids (aspartate and glutamate), prostacyclins, prostaglandins (PGE2), and leukotrienes, which will later stimulate the spinal cord and cause pain (Bonjardim et al 2011, Venancio et al 2011. In accordance, literature data have indicated that quinoline derivative compounds (present important) important antinociceptive activity (Nogueira et al 2003, Pavin et al 2011, Sari et al 2014, Pinz et al 2016). …”

“…Our research group has described the synthesis and pharmacological properties of quinolines and their derivatives, demonstrating potential antioxidant (Saraiva et al 2016, Savegnago et al 2013) and antinociceptive effects (Wilhelm et al 2014, Pinz et al 2016. Following our longstanding interest in pharmacological and toxicological properties of quinoline and its derivatives, this study investigated the in vitro antioxidant and toxicological effects of quinoline derivative containing or not selenium.…”

Evaluation of Se-phenyl-thiazolidine-4-carboselenoate protective activity against oxidative and behavioral stress in the maniac model induced by ouabain in male rats

“…Evidence has been provided indicating that organoselenium compounds could be considered as potential antioxidant and neuroprotector compounds, besides their ability to prevent disease, which turns them a target for pharmacological studies [3,4,5,6,7,8]. 4 Selenium is an essential trace element nutritionally important to mammals, with physiological roles as a structural component of antioxidant enzymes involved in the peroxide decomposition [9,10].…”

Antinociceptive and anti-inflammatory effects of 1,2-bis-(4 methoxyphenylselanyl) styrene in mice: involvement of the serotonergic system

“…Under this point of view, organoselenium compounds are believed to be an important source of new chemical substances with potential therapeutic applications . Accordingly, our research group and contributors have investigated the antinociceptive and anti‐inflammatory properties of different organoselenium compounds that might be relevant therapeutic targets for the management of pain . Savegnago et al .…”