4-Quinazolinones: synthesis and reduction of prostaglandin E2 production

Preparation of Fused Tetracyclic Quinazolinones by Combinations of Aza‐Wittig Methodologies and CuI‐Catalysed Heteroarylation Processes

“…This is in part due to the broad spectrum of biological properties of these compounds. Some of these activities include antimicrobial, [1] anti-inflammatory, [2] antifungal, [3] anticancer and AMPA receptor antagonistic properties. [4] The range of biological activities and characteristic chemical structures have made synthetic studies of quinazolinones very attractive.…”

Synthesis of 3‐aminoalkyl‐2‐arylaminoquiazolin‐4(3H)‐ones and 3,3′‐disubstituted bis‐2‐arylaminoquinazolin‐4(3H)‐ones via reactions of 1‐aryl‐3‐(2‐ethoxycarbonylphenyl)carbodiimides with diamines

“…This is due, in part, to the broad spectrum of their biological properties. Some of these activities include antimicrobial [5,6], anti-inflammatory [7,8], antifungal [9], anticancer [10], antidiabetic [11], anticonvulsant [12], analgesic [13], antibacterial [14], protein tyrosine kinase inhibitors [15], EGFR inhibitors [16], PDGFR phosphorylation inhibitors [17], CNS depressants [18], antitumor activity [19] and AMPA receptor-antagonistic properties [20,21]. Furthermore, the heterocyclic core constitutes more than 40 alkaloids [22] isolated from natural products, and some show interesting biological profiles such as antimalarial [23] and diuretic [24] properties.…”

New Efficient Synthesis of 2-Aryloxy-4(3h)-Quinazolinones

“…Some of these activities include antimicrobial(l,2), antiinflammotory (3,4), antifungal(5-7), anticancer (8) and AMPA receptor antagonistical properties (9,10). The range of biological activities and characteristic chemical structures have made synthetic studies of quinazolinones very attractive.…”