4-Year Outcomes After Left Atrial Appendage Closure Versus Nonwarfarin Oral Anticoagulation for Atrial Fibrillation

Optimal therapy for stroke prevention in atrial fibrillation: Is it left atrial appendage closure?

“…Closure with the Watchman device met noninferiority for the composite endpoint of cardiovascular death, all‐stroke/transient ischemic attack, clinically relevant bleeding, and device/procedure‐related complications) (subdistribution HR = 0.81, 95% CI: 0.56–1.18, p = .27, p value for noninferiority = .006). There was a numerical but not statistically significant increase in the all‐stroke rate (HR: 1.38, 95% CI: 0.63–3.03, p = .42) 8 …”

“…There was a numerical but not statistically significant increase in the all-stroke rate (HR: 1.38, 95% CI: 0.63-3.03, p = .42). 8 It is unclear how the data from Watchman would extend to surgical LAA occlusion. While these surgical techniques appear promising, the data presented in the review article by Sarris-Michopoulos et al is entirely from observational studies.…”

Optimal Therapy for Stroke Prevention in Atrial Fibrillation: Is it Left Atrial Appendage Closure?

“…There was a numerical but not statistically significant increase in the all-stroke rate (HR 1.38, 0.63-3.03, p =0.42). 8 It is unclear how the data from Watchman would extend to surgical LAA occlusion. While these surgical techniques appear promising, the data presented in the review article by Sarris-Michopoulos et al is entirely from observational studies.…”

Perkutaner Vorhofohrverschluss nach Schlaganfall

“…Es zeigte sich eine Nichtunterlegenheit des perkutanen Vorhofohrverschlusses bzgl. des primären Endpunkts (Schlaganfall/TIA, klinisch signifikante Blutung, kardiovaskuläre Mortalität) 28 , 29 . Es wurden keine signifikanten Unterschiede in den einzelnen Komponenten des Endpunktes beobachtet.…”