[40] Ceruloplasmin

Arnaúd, Philippe; Gianazza, Elisabetta; Miribel, Laurent

doi:10.1016/0076-6879(88)63042-4

Cited by 43 publications

(23 citation statements)

References 40 publications

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“…Ceruloplasmin protects polyunsaturated fatty acids in the red blood cell membranes from active oxygen radicals (Sass-Kortsak, 1965;Arnaud et al, 1988). It acts as a ferroxidase and superoxide dismutase.…”

Section: Discussionmentioning

confidence: 99%

“…It has a major role in the metabolism of copper to which it binds reversibly. It also acts as ferroxidase and SOD, and it protects polyunsaturated fatty acids in red blood cell membranes from active oxygen radicals (Sass-Kortsak, 1965;Arnaud et al, 1988). Transferrin is present principally in serum, but is also found at lower concentrations in other body fluids.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress in autism: Increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin - the antioxidant proteins

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxidative stress in autism: Increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin - the antioxidant proteins

et al. 2004

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“…The, acute phase protein ceruloplasmin is a regulator for hepatic iron mobilization as well as a scavenger of free radicals and superoxides [44,45]. A higher activity of ceruloplasmin level was found in summer season.…”

Section: Discussionmentioning

confidence: 99%

Haematological and innate immune responses in Puntius sarana: normal range and seasonal variation

2012

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A study was conducted to measure the normal ranges, seasonal and annual variations in haematological and immune parameters of juvenile healthy Puntius sarana (weighing 75–100 g) during three major seasons over two consecutive years. Significantly (P<0.05) lower serum myeloperoxidase and ceruloplasmin activities, superoxide production, plasma glucose level, packed cell volume and haemoglobin concentration were detected in winter as compared to the summer season. However, serum lysozyme activity, antiprotease activity, total erythrocyte count (TEC) and TLC profiles were consistent during all seasons. The reference intervals (25th–75th) of each parameter were estimated and a range was established. The annual changes in immune parameters with minimum and maximum values were measured and a significant variation was noticed in myeloperoxidase, antiprotease, total protein levels and TEC over two consecutive years. The lower levels in haematological and innate immune status of fish during winter possibly indicate a higher disease risk period for the species.

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“…[5] It also acts as ferroxidase and super oxide dismutase, and it protects polyunsaturated fatty acids in red blood cell membranes from active oxygen radicals. [6,7] It has been reported that the lower levels of ceruloplasmin and transferrin are directly manifesting the state of ASD in children with loss of acquired language skills. [5] The high prevalence of ASD among children in the Western industrialized countries has become a major alarming concern.…”

Section: Introductionmentioning

confidence: 99%

Reduced levels of antioxidant proteins in children with autism in Oman

Essa

Waly

Al-Sharbati

et al. 2012

Int J Nutr Pharmacol Neurol Dis

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Background: Autism spectrum disorder (ASD) is a severe neuro-developmental disorder with poorly understood etiology. Numerous studies evidenced that oxidative stress and altered antioxidant status could be involved in the pathophysiology of ASD. It is also reported that the altered levels of antioxidant proteins such as ceruloplasmin (copper-binding protein) and transferrin (iron-binding protein) could enhance the oxidative stress directly or indirectly and it can considerably retard acquired language skills in autistic children. But these types of studies in children with autism in Oman were not available. Materials and Methods: To reveal this paradigm, in this study, we evaluated the plasma levels of ceruloplasmin and transferrin in Omani autistic children and compared the results with age matched control children (n = 20). Results: In accordance with the previous reports, significantly lower plasma levels of ceruloplasmin and of transferrin were observed in Omani autistic children as compared to normal children. Conclusion:This suggests that such changes may lead to abnormalities of iron and copper metabolism, resulting in the enhancement of the oxidative stress and contributing to the pathogenesis of ASD. However, the underlying mechanism is still unclear and further extensive studies are warranted.

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[40] Ceruloplasmin

Cited by 43 publications

References 40 publications

Oxidative stress in autism: Increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin - the antioxidant proteins

Oxidative stress in autism: Increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin - the antioxidant proteins

Haematological and innate immune responses in Puntius sarana: normal range and seasonal variation

Reduced levels of antioxidant proteins in children with autism in Oman

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