400 Do Baseline Synovitis and Effusion Predict Tibiofemoral Cartilage Loss Over 30 Months in Subjects Without Radiographic Osteoarthritis? Results From the Multicenter Osteoarthritis (Most) Study

Roemer, Frank W.; Guermazi, Ali; Felson, David T.; Niu, Jingbo; Nevitt, Michael C.; Crema, M.D.; Lynch, J.A.; Lewis, C.E.; Torner, J.; Zhang, Y.

doi:10.1016/s1063-4584(09)60421-0

Cited by 3 publications

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“…The semiautomated assessment techniques evaluated in this work have demonstrated a much shorter analysis time and have been shown to correlate very well with manual segmentation techniques. In the future, use of these semiautomated techniques may allow synovitis volumes to be used as biomarkers for evaluating and monitoring the effectiveness of interventional therapy targeting synovitis reduction as there is evidence that synovitis not only represents a secondary phenomenon in patients with knee OA but also plays a role in progression of cartilage loss (7–9).…”

Section: Discussionmentioning

confidence: 99%

“…Synovial thickening has been shown to be associated with symptoms and to directly relate to the severity of pain in knee OA (7). Some studies have also shown a correlation between synovitis and the progression of cartilage changes, albeit this relation is being discussed controversially (7–9). On MRI, synovitis is defined as thickening and enhancement of the synovial membrane after intravenous administration of contrast agents (10).…”

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confidence: 99%

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Assessment of synovitis in the osteoarthritic knee: Comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast‐enhanced fat‐suppressed T₁‐weighted MRI

Fotinos-Hoyer

Guermazi

Jara

et al. 2010

Magnetic Resonance in Med

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Osteoarthritic joints regularly exhibit synovitis, which is ideally assessed on contrast-enhanced MRI. Manual segmentation is the reference standard for volumetric analysis but is labor intensive. The aim was to evaluate alternative semiautomated approaches of targeted thresholding and gaussian deconvolution. Volumetric and semiquantitative synovitis assessment was compared in addition. Thirty-two knees with osteoarthritis were scanned on a 1.5-T system. Synovitis volumes were plotted against each other and distributions fit with linear functions. The relationship between semiquantitative scores and synovitis volumes was assessed using Spearman's correlation coefficient. Semiautomated volume measurement was more time efficient than manual segmentation and showed a high correlation with manual analysis (R 2 5 0.88 and 0.82). Manual segmentation was correlated with summed and with maximum semiquantitative synovitis scores (r 5 0.71 and 0.47). In conclusion, semiautomated analysis provides comparable quantitative results when compared to manual segmentation but is approximately five times more time efficient. Semiquantitative assessment adds anatomic information on synovitis distribution. Magn Reson Med 64:604-609,

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Section: Discussionmentioning

confidence: 99%

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Assessment of synovitis in the osteoarthritic knee: Comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast‐enhanced fat‐suppressed T₁‐weighted MRI

Fotinos-Hoyer

Guermazi

Jara

et al. 2010

Magnetic Resonance in Med

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“…However, not adjusting for joint effusion did not alter the findings of the present study. Based on results of a recent study which reported that joint effusion predicts cartilage loss in knees without OA,23 one could speculate that joint effusion might be a risk factor for incident OA. Such an association, however, has not been shown so far.…”

Section: Discussionmentioning

confidence: 99%

Cyst-like lesions of the knee joint and their relation to incident knee pain and development of radiographic osteoarthritis: the MOST study

Guermazi

Hayashi

Roemer

et al. 2010

Osteoarthritis and Cartilage

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Objective To determine whether intra- and periarticular cyst-like lesions of the knee are associated with incident knee pain and incident radiographic knee osteoarthritis (OA). Design The Multicenter Osteoarthritis (MOST) Study is a cohort of individuals who have or are at high risk for knee OA. Using a nested case-control study design, we investigated the associations of cyst-like lesions (Baker’s, meniscal and proximal tibiofibular joint (PTFJ) cysts, and prepatellar and anserine bursitides) with (a) incident pain at 15- or 30-month follow-up and (b) incident radiographic OA at 30-month follow-up. Baseline cyst-like lesions were scored semiquantitatively using the Whole Organ Magnetic Resonance Imaging Score (WORMS). Conditional logistic regression models were used to assess the relation between these lesions and the outcomes, adjusting for potential confounding factors (i.e. cartilage loss, meniscal damage, bone marrow lesions, synovitis and joint effusion, which were also scored using WORMS). Results Incident knee pain study included 157 cases and 336 controls. Prevalence of meniscal and PTFJ cysts in the case group was twice that in the control group (9 (6%) vs. 9 (3%) and 9 (6%) vs. 10 (3%), respectively). Incident radiographic OA study included 149 cases and 298 controls. Prevalence of grade 2 Baker’s cysts and PTFJ cysts in the case group was approximately 4 times that in the control group (16 [11%] vs. 9 [3%] and 6 [4%] vs. 3 [1%], respectively). However, none of the cyst-like lesions was associated with incident pain or radiographic OA after fully adjusted logistic regression analyses and correction of p-values for multiple comparisons. Conclusion None of the analyzed lesions was an independent predictor of incident knee pain or radiographic OA. Intra- and periarticular cyst-like lesions are likely to be a secondary phenomenon seen in painful or OA-affected knees, rather than a primary trigger for incident knee pain or radiographic OA.

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“…In another study, Roemer et al analyzed if presence of baseline synovitis and effusion in knees without ROA predicted future tibio‐femoral cartilage loss. The investigation used the longitudinal Multicenter Osteoarthritis Study.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of osteoarthritis and prognosis of tibial cartilage loss by quantification of tibia trabecular bone from MRI

Marques

Genant

Lillholm

et al. 2012

Magnetic Resonance in Med

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A longitudinal study was used to investigate the quantification of osteoarthritis and prediction of tibial cartilage loss by analysis of the tibia trabecular bone from magnetic resonance images of knees. The Kellgren Lawrence (KL) grades were determined by radiologists and the levels of cartilage loss were assessed by a segmentation process. Aiming to quantify and potentially capture the structure of the trabecular bone anatomy, a machine learning approach used a set of texture features for training a classifier to recognize the trabecular bone of a knee with radiographic osteoarthritis. Using cross-validation, the bone structure marker was used to estimate for each knee both the probability of having radiographic osteoarthritis (KL >1) and the probability of rapid cartilage volume loss. The diagnostic ability reached a median area under the receiver-operator-characteristics curve of 0.92 (P < 0.0001), and the prognosis had odds ratio of 3.9 (95% confidence interval: 2.4-6.5). The medians of cartilage loss of the subjects classified as slow and rapid progressors were 1.1% and 4.9% per year, respectively. A preliminary radiological reading of the high and low risk knees put forward an hypothesis of which pathologies the bone marker could be capturing to define the prognosis of cartilage loss.

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400 Do Baseline Synovitis and Effusion Predict Tibiofemoral Cartilage Loss Over 30 Months in Subjects Without Radiographic Osteoarthritis? Results From the Multicenter Osteoarthritis (Most) Study

Cited by 3 publications

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Assessment of synovitis in the osteoarthritic knee: Comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast‐enhanced fat‐suppressed T₁‐weighted MRI

Assessment of synovitis in the osteoarthritic knee: Comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast‐enhanced fat‐suppressed T₁‐weighted MRI

Cyst-like lesions of the knee joint and their relation to incident knee pain and development of radiographic osteoarthritis: the MOST study

Diagnosis of osteoarthritis and prognosis of tibial cartilage loss by quantification of tibia trabecular bone from MRI

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400 Do Baseline Synovitis and Effusion Predict Tibiofemoral Cartilage Loss Over 30 Months in Subjects Without Radiographic Osteoarthritis? Results From the Multicenter Osteoarthritis (Most) Study

Cited by 3 publications

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Assessment of synovitis in the osteoarthritic knee: Comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast‐enhanced fat‐suppressed T1‐weighted MRI

Assessment of synovitis in the osteoarthritic knee: Comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast‐enhanced fat‐suppressed T1‐weighted MRI

Cyst-like lesions of the knee joint and their relation to incident knee pain and development of radiographic osteoarthritis: the MOST study

Diagnosis of osteoarthritis and prognosis of tibial cartilage loss by quantification of tibia trabecular bone from MRI

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Assessment of synovitis in the osteoarthritic knee: Comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast‐enhanced fat‐suppressed T₁‐weighted MRI

Assessment of synovitis in the osteoarthritic knee: Comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast‐enhanced fat‐suppressed T₁‐weighted MRI