405P Prognostic value of neoadjuvant rectal score in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy

Abstract

gaining increasing attention. Our aim was to analyse the prognostic value of CRP and explore the association between tumour sidedness and SIR.Methods: 2061 patients treated for stage I-III CRC, identified from the prospectively sampled ScotScan Collaborative dataset, were included. The clinical and prognostic value of five different CRP levels was examined (<10, 11-30, 31-60, 61-100 and >100 mg/l). Additionally, the relationship between SIR and tumour sidedness was explored.Results: Increasing levels of CRP were associated with impaired overall and cancerspecific outcome. Presence of SIR was independently associated with right-sided tumour location (odds ratio [OR] 1.19, 95% CI 1.07-1.31). The impact of SIR on cancerspecific survival was greater for left-sided tumour location (hazard ratio [HR] 1.50, 95% CI 1.18-1.92), compared to the right (HR 1.28, 95% CI 1.00-1.64).Conclusions: This study confirms CRP as an easy, valid and clinically relevant strong prognostic marker of SIR in CRC patients. Right-sided tumours were more often associated with SIR, but the prognostic impact was stronger in left-sided tumours.