406 IL-21 regulates the balance of Th17 and Treg in psoriasis

An update on the role of long non-coding RNAs in psoriasis

“…[ 34 ] However, the number of Treg cells in peripheral blood of psoriasis patients decreased, which can be counteracted by anti-TNF-α treatments. [ 35 ] Chen et al [ 36 ] found that expression levels of IL-21 in CD4 + T cells derived from patients were higher in vitro , which can promote differentiation and proliferation of Th17 cells and inhibit differentiation of Tregs, causing an imbalance of Th17/Treg cells.…”