Objective: Prospective data on the associations between vitamin D intake and risk of CVD and all-cause mortality are limited and inconclusive. The aim of the present study was to investigate the associations between vitamin D intake and CVD risk and all-cause mortality in the Caerphilly Prospective Cohort Study. Design: The associations of vitamin D intake with CVD risk markers were examined cross-sectionally at baseline and longitudinally at 5-year, 10-year and >20-year follow-ups. In addition, the predictive value of vitamin D intake for CVD events and all-cause mortality after >20 years of follow-up was examined. Logistic regression and general linear regression were used for data analysis. Setting: Participants in the UK. Subjects: Men (n 452) who were free from CVD and type 2 diabetes at recruitment. Results: Higher vitamin D intake was associated with increased HDL cholesterol (P = 0·003) and pulse pressure (P = 0·04) and decreased total cholesterol:HDL cholesterol (P = 0·008) cross-sectionally at baseline, but the associations were lost during follow-up. Furthermore, higher vitamin D intake was associated with decreased concentration of plasma TAG at baseline (P = 0·01) and at the 5-year (P = 0·01), but not the 10-year examination. After >20 years of follow-up, vitamin D was not associated with stroke (n 72), myocardial infarctions (n 142), heart failure (n 43) or all-cause mortality (n 281), but was positively associated with increased diastolic blood pressure (P = 0·03). Conclusions: The study supports associations of higher vitamin D intake with lower fasting plasma TAG and higher diastolic blood pressure.
KeywordsVitamin D CVD All-cause mortality Caerphilly Prospective Cohort Study TAG Recently, the UK Scientific Advisory Committee on Nutrition (1) reported that 22-24 % of individuals aged 19-64 years and 17-24 % of those aged ≥65 years in the UK were vitamin D deficient (plasma 25-hydroxycholecalciferol <25 nmol/l).People generally obtain vitamin D from synthesis in the skin due to sunlight UV radiation and/or foods. However, a number of relatively recent lifestyle changes (increased working indoors, sunscreen use), personal characteristics (ageing, skin pigmentation) and geographic reasons (latitude) limit the ability to synthesise adequate vitamin D from sunlight (2) . As a result, vitamin D intake from foods has become more important than previously. This led the Scientific Advisory Committee on Nutrition to recommend a daily vitamin D intake of 10 µg for all adults within the UK (1) . CVD is one of the main causes of morbidity and mortality in the world and there is mounting evidence indicating an association between suboptimal vitamin D status and increased risk of CVD (3)(4)(5)(6) and all-cause mortality (7)(8)(9) . However, few prospective cohort studies have analysed the relationship between vitamin D intake and CVD risk and allcause mortality. In a 10-year cohort of 361 men and 394 women (10) , lower vitamin D intake was associated with an increased risk of stroke, but not myocardial...