40years of cardiac rehabilitation and secondary prevention in post-cardiac ischaemic patients. Are we still in the wilderness?

Jelinek, Michael; Thompson, David R.; Bunker, Stephen; Vale, Margarite J.

doi:10.1016/j.ijcard.2014.10.154

Cited by 53 publications

(50 citation statements)

References 113 publications

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“…CR is the coordinated sum of activities required to influence the underlying cause of ASCVD favorably and to ensure the best possible physical, mental, and social conditions so that patients might preserve or assume a secure position in their community and slow or reverse www.impactjournals.com/oncotarget/ Oncotarget, Advance Publications 2018 disease progression by improving their health behavior [5]. A comprehensive exercise-based CR is safe and beneficial for patients with ASCVD, including those with acute myocardial infarction (AMI) [6,7].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Screened microRNAs related to endothelial progenitor cells and verified the target gene of microRNA-126-3p

Deng¹,

Xu²,

Li³

et al. 2018

Oncotarget

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Background: Endothelial progenitor cell play a vital role in neovascularization. Exercise-based cardiac rehabilitation significantly increases endothelial progenitor cells number and functions in patients with ischemic disease. Exercise can also increase the level of endothelial microRNAs. We hypothesized that microRNAs participate in regulating endothelial progenitor cell function under aerobic exercise. Thus, we attempted to identify such microRNAs and to verify the miR-126-3p target gene.Methods: Microarray is used to screen the microRNAs. The prediction programs TargetScan is used to predict the miR-126-3p target gene. Experimental EPCs are treated with miR-126-3p mimics. The relative expression of miR-126-3p and Mus musculus sprouty-related EVH1 domain-containing 1 (Spred1) are examined using real-time PCR and western blot. The dual-luciferase reporter assay is used to verify the miR-126-3p target gene.Results: The miR-126-3p target genes included those contributing to angiogenesis and revascularization. The predicted miR-126-3p target gene is Spred1. Compared with the control, miR-126-3p relative expression is highest following 48-h treatment with 50 nM miR-126-3 mimic. Spred1 mRNA and protein expression in the experimental group is 40.7% and 45.7%. The ratio of Renilla and firefly luciferase activity in the wild-type group is 88.3% and 74.2% of the control respectively (all, n = 3, p < 0.001).Conclusion: miR-126-3p participates in regulating endothelial progenitor cell function after aerobic exercise. MiR-126-3p inhibits the transcription and translation of Spred1, the target gene of miR-126-3p.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Screened microRNAs related to endothelial progenitor cells and verified the target gene of microRNA-126-3p

Deng¹,

Xu²,

Li³

et al. 2018

Oncotarget

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“…4 Cardiac rehabilitation programs have traditionally been delivered in a supervised center setting, typically at a local hospital, 4 but because of the current problem of poor uptake, alternative CR delivery models have been developed, including the delivery of CR in a nonsupervised home-based setting. 5,6 A core component of CR is exercise training. Adequate exercise intensity is a key consideration as it is closely associated with the level of improvement in exercise capacity and associated reduction in future cardiac events.…”

mentioning

confidence: 99%

“…20,21 It has therefore been argued that heart disease patients may lack the ability to follow individualized exercise prescription when in a nonsupervised setting. 20 Given the importance of alternative delivery methods, including unsupervised home-based programs to increase the uptake in CR, 5,6 simple methods for patients to prescribe exercise intensity are needed. Thus, we require evidence for the usability of RPE across CR settings.…”

mentioning

confidence: 99%

Is the Cardiovascular Response Equivalent Between a Supervised Center-Based Setting and a Self-care Home-Based Setting When Rating of Perceived Exertion Is Used to Guide Aerobic Exercise Intensity During a Cardiac Rehabilitation Program?

Tang

Zwisler

Berg

et al. 2017

American Journal of Physical Medicine &Amp; Rehabilitation

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Objectives: The aim of this study was to investigate if exercise intensity guided by rating of perceived exertion (RPE) results in an equivalent cardiovascular response when applied in either a center-based or a home-based setting. Design: Data from patients with heart disease (post-valve surgery and atrial fibrillation post-radiofrequency ablation) participating in exercisebased rehabilitation were included. Patients performed a 12-week program in either a center-or a home-based setting. Using RPE, patients recorded their exercise intensity 3 times during an aerobic training phase. Exercise intensity was objectively measured using heart rate (HR) monitors. Results: A total of 2622 RPE values with corresponding HR data were available. There was no difference in the level of association (interaction P = 0.51) between HR and RPE seen in the center-based setting (mean of 6.1 beats/min per 1.0 difference in RPE; 95% confidence interval, 4.8-7.5 beats/min) compared with the home-based setting (mean of 5.3 beats/min per 1.0 difference in RPE; 95% confidence interval, 4.0-6.5 beats/min). The level of patient familiarization, exercise intensity, and patient characteristics did not affect the level of association between RPE and HR. Conclusions: Independent of exercise setting, RPE appears to be equally effective in guiding exercise intensity of patients participating in cardiac rehabilitation.

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“…Traditional centre-based cardiac rehabilitation (CR) programmes have been developed and evaluated in various countries for more than four decades 1. The evidence for the effectiveness of CR in coronary heart disease has been accumulating and the benefits in terms of reductions in cardiovascular mortality and unplanned hospital readmissions coupled with an improvement in health-related quality of life 2.…”

mentioning

confidence: 99%

Telehealth technologies could improve suboptimal rates of participation in cardiac rehabilitation

Dalal

Taylor

2016

Heart

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40years of cardiac rehabilitation and secondary prevention in post-cardiac ischaemic patients. Are we still in the wilderness?

Cited by 53 publications

References 113 publications

WITHDRAWN: Screened microRNAs related to endothelial progenitor cells and verified the target gene of microRNA-126-3p

WITHDRAWN: Screened microRNAs related to endothelial progenitor cells and verified the target gene of microRNA-126-3p

Is the Cardiovascular Response Equivalent Between a Supervised Center-Based Setting and a Self-care Home-Based Setting When Rating of Perceived Exertion Is Used to Guide Aerobic Exercise Intensity During a Cardiac Rehabilitation Program?

Telehealth technologies could improve suboptimal rates of participation in cardiac rehabilitation

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