41 Cases of Treatment of Cranial Cruciate Ligament Rupture with Porous TTA: Three Years of Follow Up

Trisciuzzi, Rodrigo; Fracassi, Laura; Martin, Hernando Afonso; Forleo, Donato Monopoli; Amat, Daniel; Santos-Ruíz, Leonor; Palma, Elena De; Crovace, Alberto Maria

doi:10.3390/vetsci6010018

Cited by 14 publications

(25 citation statements)

References 34 publications

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“…Clinical evolution was satisfactory in all cases and none of them had more displacement than the originally experienced. Trisciuzzi et al (2019) showed a very similar rate of distal longitudinal TT fractures (17.07%), but they needed to perform surgery again in one case [23]. In this study, there was one case that had a distal TT fissure in the first follow-up and lameness after rest, which could suggest unsatisfactory evolution; however it is important to note that the dog arrived after 1.5 months of lameness and already had mild OA (according to the Bioarth Scale [24]) in the preoperative radiographic study.…”

Section: Discussionmentioning

confidence: 94%

Short-term outcomes and complications of 65 cases of porous TTA with flange: a prospective clinical study in dogs

Bernardi-Villavicencio

Jimenez-Socorro

Rojo-Salvador

et al. 2020

BMC Vet Res

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Background: Cranial cruciate ligament rupture (CrCLR) is the most common orthopaedic cause of lameness in the hind limb in dogs. Many surgical treatments have been described, but tibial tuberosity advancement (TTA) is one of the most commonly used today. Since it was first described, TTA has evolved to reduce major complications and to arrest the progression of osteoarthrosis. The aim of this study was to assess a surgical technique called Porous TTA with flange prospectively. This study was performed in 61 dogs that underwent 65 Porous TTA with flange procedures, to validate it as an alternative CrCLR treatment. Complications and clinical outcomes (pain, lameness, weight bearing, flexion, extension, crepitation and atrophy) were reported over 3 months, i.e. at 3, 6 and 12 weeks postoperatively. Results: The results showed a positive clinical outcome, a minor complication rate of 47.69% at the first review 3 weeks postoperatively, 10.77% at the second one (6 weeks after the surgery) and 4% at the third one (at 12 weeks). Major complications were observed only at the last review, with one case that had an infection requiring implant removal; this represented 1.5% of cases. Variables evaluated for a relationship with complication scores and improvement were body condition score, sex, age, breed, body weight, breed size, side of the affected limb, traumatic anamnesis and time of lameness before surgery. No relationship was detected. Conclusions: Clinical outcomes and complications show that Porous TTA with flange is an efficient alternative for surgical treatment of CrCLR in dogs.

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Section: Discussionmentioning

confidence: 94%

Short-term outcomes and complications of 65 cases of porous TTA with flange: a prospective clinical study in dogs

Bernardi-Villavicencio

Jimenez-Socorro

Rojo-Salvador

et al. 2020

BMC Vet Res

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“…Although, in our study, we employed a titanium scaffold consisting of a gyroid architecture with porous size of 1.5 × 2.4 mm with an elongation of 2% along the mechanical load, another study of smaller porous sizes (400–700 µm) was recently implanted in dogs’ tibiae, providing optimal osteointegration. [ 32 ]…”

Section: Discussionmentioning

confidence: 99%

3D Biomimetic Porous Titanium (Ti6Al4V ELI) Scaffolds for Large Bone Critical Defect Reconstruction: An Experimental Study in Sheep

Crovace

Lacitignola²,

Forleo

et al. 2020

Animals

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The main goal in the treatment of large bone defects is to guarantee a rapid loading of the affected limb. In this paper, the authors proposed a new reconstructive technique that proved to be suitable to reach this purpose through the use of a custom-made biomimetic porous titanium scaffold. An in vivo study was undertaken where a complete critical defect was experimentally created in the diaphysis of the right tibia of twelve sheep and replaced with a five-centimeter porous scaffold of electron beam melting (EBM)-sintered titanium alloy (EBM group n = 6) or a porous hydroxyapatite scaffold (CONTROL group, n = 6). After surgery, the sheep were allowed to move freely in the barns. The outcome was monitored for up to 12 months by periodical X-ray and clinical examination. All animals in the CONTROL group were euthanized for humane reasons within the first month after surgery due to the onset of plate bending due to mechanical overload. Nine months after surgery, X-ray imaging showed the complete integration of the titanium implant in the tibia diaphysis and remodeling of the periosteal callus, with a well-defined cortical bone. At 12 months, sheep were euthanized, and the tibia were harvested and subjected to histological analysis. This showed bone tissue formations with bone trabeculae bridging titanium trabeculae, evidencing an optimal tissue-metal interaction. Our results show that EBM-sintered titanium devices, if used to repair critical bone defects in a large animal model, can guarantee immediate body weight-bearing, a rapid functional recovery, and a good osseointegration. The porous hydroxyapatite scaffolds proved to be not suitable in this model of large bone defect due to their known poor mechanical properties.

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“…Согласно литературным данным, первичная фиксация 3D-изделий выполняется разными способами. Чаще эту функцию несут на себе элементы конструкции либо дополнительные внутренние фиксаторы, выполненные в виде балок с отверстиями, винты и шурупы [40,41,42]. A.M. Crovace с соавторами в эксперименте на овцах при замещении дефекта большеберцовой кости величиной 5 см 3D-биомиметическими пористыми титановыми каркасами, в качестве фиксаторов успешно применяли накостные пластины и кортикальные винты.…”

Section: обсуждение основного результата исследованияunclassified

Efficiency of 3D Implants with Bioactive Properties for Treatment of Extensive Bone Defects: Experimental Study

Попков

Кононович

Горбач

et al. 2021

Traumatology and Orthopedics of Russia

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Background. The problem of replacing extensive bone defects remains relevant. The use of implant structures with bioactive properties can stimulate osteogenesis, which will improve the final treatment result.The aim of the study. In an in vivo experiment, to study the possibility of replacing an extensive defect in the bone diaphysis with a personal bioactive cellular 3D implant and evaluate the long-term results of its use.Materials and Methods. In an in vivo experiment, adult large mongrel dogs (n = 8) were modeled with an extensive segmental defect of the tibial diaphysis measuring 4 cm. The defect was replaced with a cellular bioactive 3D implant made of titanium alloy Ti6Al4V, manufactured using the additive technology. The diameter of the cells was 1.5 mm on average. The walls of the implant had pores of 100– 300 μm in size. The inner and outer surfaces were coated with a calcium phosphate layer formed by micro-arc oxidation. The primary fixation was provided with the Ilizarov apparatus. In the early postoperative period, antibiotic prophylaxis with broad-spectrum drugs was performed. Clinical, X-ray, histological and statistical methods were used to analyze the results. The main control points were considered: the end of external fixation with the Ilizarov apparatus, after 180 days and 1 year after the termination of external fixation.Results. During the experiment, the death of animals and complications were not observed. The spatial location of the implant was preserved. The formation of a strong bone-implantation block occurred 37.2±6.3 days after the operation. During this period, the external fixation apparatus was dismantled. Osseointegration was provided under conditions of sufficient primary mechanical stability, due to the cellular structure of the implant, the presence of pores on its walls, and the osteoinductive properties of the applied calcium phosphate coating. The achieved degree of osseointegration persisted in long-term periods (6 months and 1 year after the termination of external fixation). The osteoinductive properties of the calcium phosphate coating were confirmed by the expression of osteopontin cells at all stages of the experiment. Outflow of Ca and P from bone fragments was not observed. An elastic sheath was formed on the surface of the implant, similar in structure to the periosteum. The implant cells were filled with a well-vascularized bone substrate. In the projection of the intermediate zone, compact bone tissue was formed, and in the projection of the medullary canal — reticulofibrous bone marrow. This indicates the possibility of organotypic remodeling of bone structures inside the implant.Conclusion. The results of the study showed the effectiveness of using a bioactive cellular 3D implant to replace an extensive defect in the shaft of the bone. The architectonics and osteoinductive properties of the implant surface contributed to the formation of complete osseointegration in a short time, while maintaining the achieved result in long-term periods.

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41 Cases of Treatment of Cranial Cruciate Ligament Rupture with Porous TTA: Three Years of Follow Up

Cited by 14 publications

References 34 publications

Short-term outcomes and complications of 65 cases of porous TTA with flange: a prospective clinical study in dogs

Short-term outcomes and complications of 65 cases of porous TTA with flange: a prospective clinical study in dogs

3D Biomimetic Porous Titanium (Ti6Al4V ELI) Scaffolds for Large Bone Critical Defect Reconstruction: An Experimental Study in Sheep

Efficiency of 3D Implants with Bioactive Properties for Treatment of Extensive Bone Defects: Experimental Study

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